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E1BIN8

- E1BIN8_BOVIN

UniProt

E1BIN8 - E1BIN8_BOVIN

Protein
Submitted name:

Uncharacterized protein

Gene

HBEGF

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. epidermal growth factor receptor signaling pathway Source: Ensembl
    2. positive regulation of keratinocyte migration Source: Ensembl
    3. positive regulation of protein kinase B signaling Source: Ensembl
    4. positive regulation of smooth muscle cell proliferation Source: Ensembl
    5. positive regulation of wound healing Source: Ensembl
    6. regulation of heart contraction Source: Ensembl
    7. wound healing, spreading of epidermal cells Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_206968. GRB2 events in ERBB2 signaling.
    REACT_208171. PIP3 activates AKT signaling.
    REACT_211997. SHC1 events in ERBB2 signaling.
    REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_216183. Signaling by ERBB4.
    REACT_218958. Signaling by ERBB2.
    REACT_219416. PI3K events in ERBB2 signaling.
    REACT_220588. Nuclear signaling by ERBB4.
    REACT_222492. PI3K events in ERBB4 signaling.
    REACT_222894. EGFR Transactivation by Gastrin.
    REACT_223442. SHC1 events in ERBB4 signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:HBEGFImported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: Ensembl
    3. integral component of plasma membrane Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000063708.
    KOiK08523.
    OMAiYSYDHTT.
    OrthoDBiEOG7VQJGP.
    TreeFamiTF332773.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR015497. EGF_rcpt_ligand.
    [Graphical view]
    PANTHERiPTHR10740. PTHR10740. 1 hit.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1BIN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNL DTPTQSTDQL    50
    LPAGGGQGRE VLDLEEANLD LFRAAFSSKP QALATPSKEE RGKRKKKGKG 100
    LGKKRNPCLR RYKDFCIHGE CKYVKELRVP TCICHPGYHG ERCHGLSLPV 150
    KNRLYTYDHT TILVVVAVVL SSVCLLVIMG LLMFWYHRRG GYDVENEEKV 200
    KLGMTTSH 208
    Length:208
    Mass (Da):23,093
    Last modified:November 2, 2010 - v1
    Checksum:iB73E5A104B563B77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02020430 Genomic DNA. No translation available.
    RefSeqiNP_001137562.1. NM_001144090.1.
    UniGeneiBt.14152.

    Genome annotation databases

    EnsembliENSBTAT00000029015; ENSBTAP00000029015; ENSBTAG00000021766.
    GeneIDi522921.
    KEGGibta:522921.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02020430 Genomic DNA. No translation available.
    RefSeqi NP_001137562.1. NM_001144090.1.
    UniGenei Bt.14152.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000029015 ; ENSBTAP00000029015 ; ENSBTAG00000021766 .
    GeneIDi 522921.
    KEGGi bta:522921.

    Organism-specific databases

    CTDi 1839.

    Phylogenomic databases

    GeneTreei ENSGT00530000063708.
    KOi K08523.
    OMAi YSYDHTT.
    OrthoDBi EOG7VQJGP.
    TreeFami TF332773.

    Enzyme and pathway databases

    Reactomei REACT_206968. GRB2 events in ERBB2 signaling.
    REACT_208171. PIP3 activates AKT signaling.
    REACT_211997. SHC1 events in ERBB2 signaling.
    REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_216183. Signaling by ERBB4.
    REACT_218958. Signaling by ERBB2.
    REACT_219416. PI3K events in ERBB2 signaling.
    REACT_220588. Nuclear signaling by ERBB4.
    REACT_222492. PI3K events in ERBB4 signaling.
    REACT_222894. EGFR Transactivation by Gastrin.
    REACT_223442. SHC1 events in ERBB4 signaling.

    Miscellaneous databases

    NextBioi 20873626.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR015497. EGF_rcpt_ligand.
    [Graphical view ]
    PANTHERi PTHR10740. PTHR10740. 1 hit.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiE1BIN8_BOVIN
    AccessioniPrimary (citable) accession number: E1BIN8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3