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Protein
Submitted name:

Uncharacterized protein

Gene

HBEGF

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. epidermal growth factor receptor binding Source: GO_Central
  2. growth factor activity Source: GO_Central
  3. heparin binding Source: GO_Central

GO - Biological processi

  1. epidermal growth factor receptor signaling pathway Source: GO_Central
  2. positive regulation of cell proliferation Source: GO_Central
  3. positive regulation of keratinocyte migration Source: Ensembl
  4. positive regulation of protein kinase B signaling Source: Ensembl
  5. positive regulation of smooth muscle cell proliferation Source: Ensembl
  6. positive regulation of wound healing Source: Ensembl
  7. regulation of heart contraction Source: Ensembl
  8. wound healing, spreading of epidermal cells Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_272952. SHC1 events in ERBB4 signaling.
REACT_282342. PI3K events in ERBB4 signaling.
REACT_285779. GRB2 events in ERBB2 signaling.
REACT_292071. Nuclear signaling by ERBB4.
REACT_307457. EGFR Transactivation by Gastrin.
REACT_311733. Constitutive PI3K/AKT Signaling in Cancer.
REACT_312239. Signaling by ERBB2.
REACT_317750. Signaling by ERBB4.
REACT_320412. PIP3 activates AKT signaling.
REACT_328500. SHC1 events in ERBB2 signaling.
REACT_353402. PI3K events in ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HBEGFImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: GO_Central
  3. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063708.
InParanoidiE1BIN8.
KOiK08523.
OMAiYSYDHTT.
OrthoDBiEOG7VQJGP.
TreeFamiTF332773.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BIN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNL DTPTQSTDQL
60 70 80 90 100
LPAGGGQGRE VLDLEEANLD LFRAAFSSKP QALATPSKEE RGKRKKKGKG
110 120 130 140 150
LGKKRNPCLR RYKDFCIHGE CKYVKELRVP TCICHPGYHG ERCHGLSLPV
160 170 180 190 200
KNRLYTYDHT TILVVVAVVL SSVCLLVIMG LLMFWYHRRG GYDVENEEKV

KLGMTTSH
Length:208
Mass (Da):23,093
Last modified:November 2, 2010 - v1
Checksum:iB73E5A104B563B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02020430 Genomic DNA. No translation available.
RefSeqiNP_001137562.1. NM_001144090.1.
UniGeneiBt.14152.

Genome annotation databases

EnsembliENSBTAT00000029015; ENSBTAP00000029015; ENSBTAG00000021766.
GeneIDi522921.
KEGGibta:522921.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02020430 Genomic DNA. No translation available.
RefSeqiNP_001137562.1. NM_001144090.1.
UniGeneiBt.14152.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029015; ENSBTAP00000029015; ENSBTAG00000021766.
GeneIDi522921.
KEGGibta:522921.

Organism-specific databases

CTDi1839.

Phylogenomic databases

GeneTreeiENSGT00530000063708.
InParanoidiE1BIN8.
KOiK08523.
OMAiYSYDHTT.
OrthoDBiEOG7VQJGP.
TreeFamiTF332773.

Enzyme and pathway databases

ReactomeiREACT_272952. SHC1 events in ERBB4 signaling.
REACT_282342. PI3K events in ERBB4 signaling.
REACT_285779. GRB2 events in ERBB2 signaling.
REACT_292071. Nuclear signaling by ERBB4.
REACT_307457. EGFR Transactivation by Gastrin.
REACT_311733. Constitutive PI3K/AKT Signaling in Cancer.
REACT_312239. Signaling by ERBB2.
REACT_317750. Signaling by ERBB4.
REACT_320412. PIP3 activates AKT signaling.
REACT_328500. SHC1 events in ERBB2 signaling.
REACT_353402. PI3K events in ERBB2 signaling.

Miscellaneous databases

NextBioi20873626.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiE1BIN8_BOVIN
AccessioniPrimary (citable) accession number: E1BIN8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: April 1, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.