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E1BIN8

- E1BIN8_BOVIN

UniProt

E1BIN8 - E1BIN8_BOVIN

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Protein
Submitted name:

Uncharacterized protein

Gene

HBEGF

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. epidermal growth factor receptor signaling pathway Source: Ensembl
  2. positive regulation of keratinocyte migration Source: Ensembl
  3. positive regulation of protein kinase B signaling Source: Ensembl
  4. positive regulation of smooth muscle cell proliferation Source: Ensembl
  5. positive regulation of wound healing Source: Ensembl
  6. regulation of heart contraction Source: Ensembl
  7. wound healing, spreading of epidermal cells Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_206968. GRB2 events in ERBB2 signaling.
REACT_208171. PIP3 activates AKT signaling.
REACT_211997. SHC1 events in ERBB2 signaling.
REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
REACT_216183. Signaling by ERBB4.
REACT_218958. Signaling by ERBB2.
REACT_219416. PI3K events in ERBB2 signaling.
REACT_220588. Nuclear signaling by ERBB4.
REACT_222492. PI3K events in ERBB4 signaling.
REACT_222894. EGFR Transactivation by Gastrin.
REACT_223442. SHC1 events in ERBB4 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HBEGFImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063708.
InParanoidiE1BIN8.
KOiK08523.
OMAiYSYDHTT.
OrthoDBiEOG7VQJGP.
TreeFamiTF332773.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BIN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNL DTPTQSTDQL
60 70 80 90 100
LPAGGGQGRE VLDLEEANLD LFRAAFSSKP QALATPSKEE RGKRKKKGKG
110 120 130 140 150
LGKKRNPCLR RYKDFCIHGE CKYVKELRVP TCICHPGYHG ERCHGLSLPV
160 170 180 190 200
KNRLYTYDHT TILVVVAVVL SSVCLLVIMG LLMFWYHRRG GYDVENEEKV

KLGMTTSH
Length:208
Mass (Da):23,093
Last modified:November 2, 2010 - v1
Checksum:iB73E5A104B563B77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02020430 Genomic DNA. No translation available.
RefSeqiNP_001137562.1. NM_001144090.1.
UniGeneiBt.14152.

Genome annotation databases

EnsembliENSBTAT00000029015; ENSBTAP00000029015; ENSBTAG00000021766.
GeneIDi522921.
KEGGibta:522921.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02020430 Genomic DNA. No translation available.
RefSeqi NP_001137562.1. NM_001144090.1.
UniGenei Bt.14152.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000029015 ; ENSBTAP00000029015 ; ENSBTAG00000021766 .
GeneIDi 522921.
KEGGi bta:522921.

Organism-specific databases

CTDi 1839.

Phylogenomic databases

GeneTreei ENSGT00530000063708.
InParanoidi E1BIN8.
KOi K08523.
OMAi YSYDHTT.
OrthoDBi EOG7VQJGP.
TreeFami TF332773.

Enzyme and pathway databases

Reactomei REACT_206968. GRB2 events in ERBB2 signaling.
REACT_208171. PIP3 activates AKT signaling.
REACT_211997. SHC1 events in ERBB2 signaling.
REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
REACT_216183. Signaling by ERBB4.
REACT_218958. Signaling by ERBB2.
REACT_219416. PI3K events in ERBB2 signaling.
REACT_220588. Nuclear signaling by ERBB4.
REACT_222492. PI3K events in ERBB4 signaling.
REACT_222894. EGFR Transactivation by Gastrin.
REACT_223442. SHC1 events in ERBB4 signaling.

Miscellaneous databases

NextBioi 20873626.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view ]
PANTHERi PTHR10740. PTHR10740. 1 hit.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiE1BIN8_BOVIN
AccessioniPrimary (citable) accession number: E1BIN8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3