ID   E1BIN3_BOVIN            Unreviewed;       574 AA.
AC   E1BIN3;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Arylsulfatase family member I {ECO:0000313|Ensembl:ENSBTAP00000017050.5};
GN   Name=ARSI {ECO:0000313|Ensembl:ENSBTAP00000017050.5,
GN   ECO:0000313|VGNC:VGNC:26177};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000017050.5, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000017050.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017050.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000017050.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000017050.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   RefSeq; XP_002689338.1; XM_002689292.5.
DR   RefSeq; XP_593725.1; XM_593725.8.
DR   AlphaFoldDB; E1BIN3; -.
DR   SMR; E1BIN3; -.
DR   STRING; 9913.ENSBTAP00000017050; -.
DR   PaxDb; 9913-ENSBTAP00000017050; -.
DR   Ensembl; ENSBTAT00000017050.5; ENSBTAP00000017050.5; ENSBTAG00000012834.5.
DR   GeneID; 540390; -.
DR   KEGG; bta:540390; -.
DR   CTD; 340075; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012834; -.
DR   VGNC; VGNC:26177; ARSI.
DR   eggNOG; KOG3867; Eukaryota.
DR   GeneTree; ENSGT00940000157656; -.
DR   HOGENOM; CLU_006332_10_1_1; -.
DR   InParanoid; E1BIN3; -.
DR   OMA; WDWMKPS; -.
DR   OrthoDB; 2913702at2759; -.
DR   TreeFam; TF314186; -.
DR   Reactome; R-BTA-1663150; The activation of arylsulfatases.
DR   Reactome; R-BTA-9840310; Glycosphingolipid catabolism.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000012834; Expressed in ureter and 74 other cell types or tissues.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR   CDD; cd16029; 4-S; 1.
DR   Gene3D; 3.30.1120.10; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR047115; ARSB.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR   PANTHER; PTHR10342:SF68; ARYLSULFATASE I; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..574
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018654026"
FT   DOMAIN          50..362
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          509..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  64461 MW;  2C92830B4973DF8E CRC64;
     MAMQALTGFS LVSLLGFGYL SWDWAKPSLV ADAPAEAGVE HPSAAPPQPP HIIFILTDDQ
     GYHDVGYHGS DIETPTLDRL AAEGVKLENY YIQPICTPSR SQLLTGRYQI HTGLQHSIIR
     PRQPNCLPLD QVTLPQKLQE LGYSTHMVGK WHLGFYRKEC LPTRRGFDTF LGSLTGNVDY
     YTYDNCDGPG VCGFDLHEGE NVAWGLSGQY STLLYAQRVS HILASHSPRQ PLFLYVAFQA
     VHTPLQSPRE YLYRYRTMGN VARRKYAAMV TCMDEAVRNI TWALKRHGFY NNSVIIFSSD
     NGGQTFSGGS NWPLRGRKGT YWEGGVRGLG FVHSPLLKRK RRTSRALVHI TDWYPTLVAL
     AGGTASAADG LDGYDVWPAI SEGRASPRTE ILHNIDPLYN HARHGSLEGG FGIWNTAVQA
     AIRVGEWKLL TGDPGYGDWI PPQTLAAFPG SWWNLERMAS ARQAVWLFNI SADPYEREDL
     AGQRPDVVRA LLARLVDYNR TAIPVRYPAE NPRAHPDFNG GAWGPWASDE EEDEEEEEGR
     AQSQSRGRRK KKCKICKLRS FFRKLNTRLM SHRI
//