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E1BFE9 (BI2L2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Short name=BAI1-associated protein 2-like protein 2
Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name=Pinkbar
Gene names
Name:BAIAP2L2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity. Cell junction By similarity. Cytoplasmic vesicle membrane By similarity. Note: Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts By similarity.

Domain

The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation By similarity.

Sequence similarities

Contains 1 IMD (IRSp53/MIM homology) domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
PRO_0000412902

Regions

Domain1 – 239239IMD
Domain329 – 39264SH3

Sequences

Sequence LengthMass (Da)Tools
E1BFE9 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: C7E5092C80382399

FASTA52959,190
        10         20         30         40         50         60 
MAPEMDQFYR STMAIYKSIL EQFNPALENL VYLGNNYLRA FHALSEAAEV YFNAIQKIGE 

        70         80         90        100        110        120 
QALQSSTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGDL LQHMEKNTKL DMQFIKDSRQ 

       130        140        150        160        170        180 
HYEMEYRHRA ANLEKSMSQL WRMERKRDKN AREMKESVNR LHAQMQAFVS ESQRAAELEE 

       190        200        210        220        230        240 
KRRYRFLAEK HLLLSNTFLQ FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPVLG 

       250        260        270        280        290        300 
PPYPSGRLTP TRLDMPQRAL GEFGSPRSRH GSGSYGPEPA EARSASQLEP DHRRSLPRTP 

       310        320        330        340        350        360 
SASSLYSSST QRSRSNSFGE RPGGGGGGGG ARRVRALVSH SEGANHTLLR FSAGDVVEVL 

       370        380        390        400        410        420 
VPEAQNGWLY GKLEGSSSSG WFPEAYVKPL DELPVNPMNP LNPVTSMNPR SPVNELPSRL 

       430        440        450        460        470        480 
RSYPLRGSHS LDDLLDRPGN STASSDYWDG QSRSRTPSHI PSRTPSPAPT PLPSSRRSSM 

       490        500        510        520 
GSMGVASDVK KLASWEQQPP ELFPRGTNPF ATVKLRPTVT NDRSAPLIR

« Hide

References

[1]"The genome sequence of taurine cattle: a window to ruminant biology and evolution."
The bovine genome sequencing and analysis consortium
Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFC03031682 Genomic DNA. No translation available.
AAFC03051115 Genomic DNA. No translation available.
IPIIPI00718699.
UniGeneBt.24822.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000020331; ENSBTAP00000020331; ENSBTAG00000015290.

Phylogenomic databases

GeneTreeENSGT00390000005995.
OMATRLDMPP.

Family and domain databases

InterProIPR013606. IRSp53/MIM_homology_IMD.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF08397. IMD. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SH3. 1 hit.
PROSITEPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBI2L2_BOVIN
AccessionPrimary (citable) accession number: E1BFE9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 2, 2010
Last modified: March 6, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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