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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Gene

BAIAP2L2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).By similarity

GO - Molecular functioni

  1. phospholipid binding Source: Ensembl

GO - Biological processi

  1. filopodium assembly Source: InterPro
  2. membrane organization Source: Ensembl
  3. regulation of actin cytoskeleton organization Source: InterPro
  4. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Short name:
BAI1-associated protein 2-like protein 2
Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name:
Pinkbar
Gene namesi
Name:BAIAP2L2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity. Cell junction By similarity. Cytoplasmic vesicle membrane By similarity
Note: Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.By similarity

GO - Cellular componenti

  1. cell-cell contact zone Source: Ensembl
  2. clathrin complex Source: Ensembl
  3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2PRO_0000412902Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 239239IMDPROSITE-ProRule annotationAdd
BLAST
Domaini329 – 39264SH3PROSITE-ProRule annotationAdd
BLAST

Domaini

The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

GeneTreeiENSGT00390000005995.
InParanoidiE1BFE9.
OMAiPSEYWDG.
OrthoDBiEOG7N0C3W.
TreeFamiTF325648.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030126. Pinkbar.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF5. PTHR14206:SF5. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BFE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPEMDQFYR STMAIYKSIL EQFNPALENL VYLGNNYLRA FHALSEAAEV
60 70 80 90 100
YFNAIQKIGE QALQSSTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGDL
110 120 130 140 150
LQHMEKNTKL DMQFIKDSRQ HYEMEYRHRA ANLEKSMSQL WRMERKRDKN
160 170 180 190 200
AREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ
210 220 230 240 250
FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPVLG PPYPSGRLTP
260 270 280 290 300
TRLDMPQRAL GEFGSPRSRH GSGSYGPEPA EARSASQLEP DHRRSLPRTP
310 320 330 340 350
SASSLYSSST QRSRSNSFGE RPGGGGGGGG ARRVRALVSH SEGANHTLLR
360 370 380 390 400
FSAGDVVEVL VPEAQNGWLY GKLEGSSSSG WFPEAYVKPL DELPVNPMNP
410 420 430 440 450
LNPVTSMNPR SPVNELPSRL RSYPLRGSHS LDDLLDRPGN STASSDYWDG
460 470 480 490 500
QSRSRTPSHI PSRTPSPAPT PLPSSRRSSM GSMGVASDVK KLASWEQQPP
510 520
ELFPRGTNPF ATVKLRPTVT NDRSAPLIR
Length:529
Mass (Da):59,190
Last modified:November 2, 2010 - v1
Checksum:iC7E5092C80382399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03031682 Genomic DNA. No translation available.
AAFC03051115 Genomic DNA. No translation available.
UniGeneiBt.24822.

Genome annotation databases

EnsembliENSBTAT00000020331; ENSBTAP00000020331; ENSBTAG00000015290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03031682 Genomic DNA. No translation available.
AAFC03051115 Genomic DNA. No translation available.
UniGeneiBt.24822.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020331; ENSBTAP00000020331; ENSBTAG00000015290.

Phylogenomic databases

GeneTreeiENSGT00390000005995.
InParanoidiE1BFE9.
OMAiPSEYWDG.
OrthoDBiEOG7N0C3W.
TreeFamiTF325648.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030126. Pinkbar.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF5. PTHR14206:SF5. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.

Entry informationi

Entry nameiBI2L2_BOVIN
AccessioniPrimary (citable) accession number: E1BFE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.