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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Gene

BAIAP2L2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Short name:
BAI1-associated protein 2-like protein 2
Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name:
Pinkbar
Gene namesi
Name:BAIAP2L2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004129021 – 529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei479PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiE1BFE9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015290.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020331.

Structurei

3D structure databases

SMRiE1BFE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 239IMDPROSITE-ProRule annotationAdd BLAST239
Domaini329 – 392SH3PROSITE-ProRule annotationAdd BLAST64

Domaini

The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).By similarity

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IFGP. Eukaryota.
ENOG4111HBF. LUCA.
GeneTreeiENSGT00390000005995.
InParanoidiE1BFE9.
OMAiPSEYWDG.
OrthoDBiEOG091G05ZV.
TreeFamiTF325648.

Family and domain databases

CDDicd11914. SH3_BAIAP2L2. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030126. Pinkbar.
IPR035593. Pinkbar_SH3.
IPR001452. SH3_domain.
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF12. PTHR14206:SF12. 1 hit.
PfamiView protein in Pfam
PF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

E1BFE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEMDQFYR STMAIYKSIL EQFNPALENL VYLGNNYLRA FHALSEAAEV
60 70 80 90 100
YFNAIQKIGE QALQSSTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGDL
110 120 130 140 150
LQHMEKNTKL DMQFIKDSRQ HYEMEYRHRA ANLEKSMSQL WRMERKRDKN
160 170 180 190 200
AREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ
210 220 230 240 250
FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPVLG PPYPSGRLTP
260 270 280 290 300
TRLDMPQRAL GEFGSPRSRH GSGSYGPEPA EARSASQLEP DHRRSLPRTP
310 320 330 340 350
SASSLYSSST QRSRSNSFGE RPGGGGGGGG ARRVRALVSH SEGANHTLLR
360 370 380 390 400
FSAGDVVEVL VPEAQNGWLY GKLEGSSSSG WFPEAYVKPL DELPVNPMNP
410 420 430 440 450
LNPVTSMNPR SPVNELPSRL RSYPLRGSHS LDDLLDRPGN STASSDYWDG
460 470 480 490 500
QSRSRTPSHI PSRTPSPAPT PLPSSRRSSM GSMGVASDVK KLASWEQQPP
510 520
ELFPRGTNPF ATVKLRPTVT NDRSAPLIR
Length:529
Mass (Da):59,190
Last modified:November 2, 2010 - v1
Checksum:iC7E5092C80382399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03031682 Genomic DNA. No translation available.
AAFC03051115 Genomic DNA. No translation available.
UniGeneiBt.24822.

Genome annotation databases

EnsembliENSBTAT00000020331; ENSBTAP00000020331; ENSBTAG00000015290.

Similar proteinsi

Entry informationi

Entry nameiBI2L2_BOVIN
AccessioniPrimary (citable) accession number: E1BFE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 2, 2010
Last modified: August 30, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome