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E1BFE9

- BI2L2_BOVIN

UniProt

E1BFE9 - BI2L2_BOVIN

Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Gene

BAIAP2L2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide By similarity.By similarity

    GO - Molecular functioni

    1. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. filopodium assembly Source: InterPro
    2. membrane organization Source: Ensembl
    3. regulation of actin cytoskeleton organization Source: InterPro
    4. signal transduction Source: InterPro

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
    Short name:
    BAI1-associated protein 2-like protein 2
    Alternative name(s):
    Planar intestinal- and kidney-specific BAR domain protein
    Short name:
    Pinkbar
    Gene namesi
    Name:BAIAP2L2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity. Cell junction By similarity. Cytoplasmic vesicle membrane By similarity
    Note: Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.By similarity

    GO - Cellular componenti

    1. cell-cell contact zone Source: Ensembl
    2. clathrin complex Source: Ensembl
    3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2PRO_0000412902Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 239239IMDPROSITE-ProRule annotationAdd
    BLAST
    Domaini329 – 39264SH3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation By similarity.By similarity

    Sequence similaritiesi

    Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    GeneTreeiENSGT00390000005995.
    OMAiRKRDKNV.
    OrthoDBiEOG7N0C3W.
    TreeFamiTF325648.

    Family and domain databases

    InterProiIPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR14206. PTHR14206. 1 hit.
    PfamiPF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1BFE9-1 [UniParc]FASTAAdd to Basket

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    MAPEMDQFYR STMAIYKSIL EQFNPALENL VYLGNNYLRA FHALSEAAEV    50
    YFNAIQKIGE QALQSSTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGDL 100
    LQHMEKNTKL DMQFIKDSRQ HYEMEYRHRA ANLEKSMSQL WRMERKRDKN 150
    AREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ 200
    FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPVLG PPYPSGRLTP 250
    TRLDMPQRAL GEFGSPRSRH GSGSYGPEPA EARSASQLEP DHRRSLPRTP 300
    SASSLYSSST QRSRSNSFGE RPGGGGGGGG ARRVRALVSH SEGANHTLLR 350
    FSAGDVVEVL VPEAQNGWLY GKLEGSSSSG WFPEAYVKPL DELPVNPMNP 400
    LNPVTSMNPR SPVNELPSRL RSYPLRGSHS LDDLLDRPGN STASSDYWDG 450
    QSRSRTPSHI PSRTPSPAPT PLPSSRRSSM GSMGVASDVK KLASWEQQPP 500
    ELFPRGTNPF ATVKLRPTVT NDRSAPLIR 529
    Length:529
    Mass (Da):59,190
    Last modified:November 2, 2010 - v1
    Checksum:iC7E5092C80382399
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03031682 Genomic DNA. No translation available.
    AAFC03051115 Genomic DNA. No translation available.
    UniGeneiBt.24822.

    Genome annotation databases

    EnsembliENSBTAT00000020331; ENSBTAP00000020331; ENSBTAG00000015290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03031682 Genomic DNA. No translation available.
    AAFC03051115 Genomic DNA. No translation available.
    UniGenei Bt.24822.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000020331 ; ENSBTAP00000020331 ; ENSBTAG00000015290 .

    Phylogenomic databases

    GeneTreei ENSGT00390000005995.
    OMAi RKRDKNV.
    OrthoDBi EOG7N0C3W.
    TreeFami TF325648.

    Family and domain databases

    InterProi IPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR14206. PTHR14206. 1 hit.
    Pfami PF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
      The bovine genome sequencing and analysis consortium
      Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.

    Entry informationi

    Entry nameiBI2L2_BOVIN
    AccessioniPrimary (citable) accession number: E1BFE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3