ID   E1BDU6_BOVIN            Unreviewed;       677 AA.
AC   E1BDU6;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   27-MAR-2024, entry version 94.
DE   SubName: Full=ATP binding cassette subfamily G member 1 {ECO:0000313|Ensembl:ENSBTAP00000028342.5};
GN   Name=ABCG1 {ECO:0000313|Ensembl:ENSBTAP00000028342.5,
GN   ECO:0000313|VGNC:VGNC:25483};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000028342.5, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000028342.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028342.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000028342.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028342.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       Eye pigment precursor importer (TC 3.A.1.204) subfamily.
CC       {ECO:0000256|ARBA:ARBA00005814}.
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DR   RefSeq; NP_001192457.1; NM_001205528.1.
DR   AlphaFoldDB; E1BDU6; -.
DR   Ensembl; ENSBTAT00000028342.5; ENSBTAP00000028342.5; ENSBTAG00000021272.5.
DR   GeneID; 510745; -.
DR   KEGG; bta:510745; -.
DR   CTD; 9619; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021272; -.
DR   VGNC; VGNC:25483; ABCG1.
DR   eggNOG; KOG0061; Eukaryota.
DR   GeneTree; ENSGT00940000160131; -.
DR   HOGENOM; CLU_000604_57_6_1; -.
DR   OrthoDB; 1126902at2759; -.
DR   TreeFam; TF105210; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000021272; Expressed in oviduct epithelium and 101 other cell types or tissues.
DR   ExpressionAtlas; E1BDU6; baseline.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0034041; F:ABC-type sterol transporter activity; IEA:Ensembl.
DR   GO; GO:0043531; F:ADP binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0120020; F:cholesterol transfer activity; IEA:Ensembl.
DR   GO; GO:0090554; F:phosphatidylcholine floppase activity; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0042987; P:amyloid precursor protein catabolic process; IEA:Ensembl.
DR   GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR   GO; GO:0034436; P:glycoprotein transport; IEA:Ensembl.
DR   GO; GO:0032367; P:intracellular cholesterol transport; IEA:Ensembl.
DR   GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR   GO; GO:0055091; P:phospholipid homeostasis; IEA:Ensembl.
DR   GO; GO:1902004; P:positive regulation of amyloid-beta formation; IEA:Ensembl.
DR   GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR   GO; GO:0033993; P:response to lipid; IEA:Ensembl.
DR   CDD; cd03213; ABCG_EPDR; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC2_TM.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005284; Pigment_permease/Abcg.
DR   NCBIfam; TIGR00955; 3a01204; 1.
DR   PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR   PANTHER; PTHR48041:SF90; ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 1; 1.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   Pfam; PF19055; ABC2_membrane_7; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        426..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        455..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        496..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        533..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        563..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        597..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        647..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          76..316
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   677 AA;  75725 MW;  9C06B7A0273063C6 CRC64;
     MACLMATFSV GTAMNGSSGM TEPKSVCVSV DEVVFSNRDR DTVEKELLNG HLKKEDNNLT
     EAQRLSSLPR RAAVNIEFKD LSYSVSEGPW WRKKGYKTLL KGISGKFNSG ELVAIMGPSG
     AGKSTLMNIL AGYRETGMKG EVLINGLPRD LRCFRKVSCY IMQDDLLLPH LTVQEAMMVS
     AHLKLQEKDE GRREMVKEIL TALGLLSCAN TRTGSLSGGQ RKRLAIALEL VNNPPVMFFD
     EPTSGLDSAS CFQVVSLMKG LAQGGRSIIC TIHQPSAKLF ELFDQLYVLS QGQCVYRGKV
     SNLVPYLRDL GLNCPTYHNP ADFVMEVASG EYGDQNGRLV RAVWEGKCDS DCRREPGGDA
     EVNPFIWHRP SEEVKQTKRW KGWRKDSTSM EGCHSFSASC LTQFCILFKR TFLSIMRDSV
     LTHLRITSHI GIGLLIGLLY LGIGNEAKKV LSNSGFLFFS MLFLMFAALM PTVLTFPLEM
     SVFLREHLNY WYSLKAYYLA KTMADVPFQI MFPVAYCSIV YWMTSQPSDA VRFVLFAALG
     TMTSLVAQSL GLLIGAASTS LQVATFVGPV TAIPVLLFSG FFVSFDTIPT YLQWMSYVSY
     VRYGFEGVIL SIYGLDREDL HCNTNETCHF QKSEAILREL DVENAKLYLD FIVLGIFFIS
     LRLIAYLVLR YKIRAER
//