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Protein

Cyclin-dependent kinase 13

Gene

CDK13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis (By similarity).By similarity

Catalytic activityi

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei735ATPPROSITE-ProRule annotation1
Active sitei838Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi712 – 720ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-BTA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 13 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13
Gene namesi
Name:CDK13
Synonyms:CDC2L, CDC2L5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004069561 – 1512Cyclin-dependent kinase 13Add BLAST1512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei341PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei401PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei440PhosphoserineBy similarity1
Modified residuei526PhosphoserineBy similarity1
Modified residuei557N6-acetyllysineBy similarity1
Modified residuei589PhosphothreonineBy similarity1
Modified residuei872PhosphothreonineBy similarity1
Modified residuei1049PhosphoserineBy similarity1
Modified residuei1059PhosphothreonineBy similarity1
Modified residuei1246PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiE1BB52.
PRIDEiE1BB52.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001528.

Interactioni

Subunit structurei

Interacts with CCNK, CCNL1 and CCNL2. Interacts with C1QBP.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002003.

Structurei

3D structure databases

ProteinModelPortaliE1BB52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini706 – 999Protein kinasePROSITE-ProRule annotationAdd BLAST294

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 14Poly-Gly5
Compositional biasi34 – 57Pro-richAdd BLAST24
Compositional biasi62 – 76Ala-richAdd BLAST15
Compositional biasi130 – 256Gly-richAdd BLAST127
Compositional biasi248 – 449Ser-richAdd BLAST202
Compositional biasi451 – 491Ala-richAdd BLAST41
Compositional biasi1215 – 1269Pro-richAdd BLAST55

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
InParanoidiE1BB52.
OMAiNVAPVKT.
OrthoDBiEOG091G08Z8.
TreeFamiTF101060.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BB52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ
60 70 80 90 100
PPPPPPPLLF LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG
110 120 130 140 150
GRQKRRRGPR AGQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS
160 170 180 190 200
SQSEQGLLLG GASAATAATA AGGTGGSGGS PASSSGTQRR GEGSERRPRR
210 220 230 240 250
DRRSSSGRSK DRHREHRRRD GQRGGGEASK SRSRHGHGGE ERAEAGKSGS
260 270 280 290 300
SSSSGGRRKS ASATSSSSSS RKDRDPKAHR SRTKSSKEPP SAYKEPPKAY
310 320 330 340 350
REDKTEPKAY RRRQRSLSPL GGRDDSPVSH RASQSLRNRK SPSPAGGGSS
360 370 380 390 400
PYSRRLARSP SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY
410 420 430 440 450
SPVIRRSAKS RSRSPYSSRH SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL
460 470 480 490 500
AAELNKNKKA RAAEAARAAE AAKAAEAAKA AEAAAKAAKA ASTSTPTKGN
510 520 530 540 550
TETGASASQT NHVKDVKKLK TEHAPSPSSG GTLKNDKAKT KPPLQVTKVD
560 570 580 590 600
NNLIVDKATK KAVVVGKESK SAATKEEPVS LKEKTKPLTP SIGAKEKEQH
610 620 630 640 650
VALVTSTLPP LPLPPMLPED KDADSLRGNI SVKAVKKEVE KKLRCLLADL
660 670 680 690 700
PLPPELPGGD DLSKSPEEKK TATQLHNKRR PKICGPRFGE IKEKDIDWGK
710 720 730 740 750
RCVDKFDIIG IIGEGTYGQV YKARDKDTGE MVALKKVRLD NEKEGFPITA
760 770 780 790 800
IREIKILRQL THQSIINMKE IVTDKEDALD FKKDKGAFYL VFEYMDHDLM
810 820 830 840 850
GLLESGLVHF NENHIKSFMR QLMEGLDYCH KKNFLHRDIK CSNILLNNRG
860 870 880 890 900
QIKLADFGLA RLYSSEESRP YTNKVITLWY RPPELLLGEE RYTPAIDVWS
910 920 930 940 950
CGCILGELFT KKPIFQANQE LAQLELISRI CGSPCPAVWP DVIKLPYFNT
960 970 980 990 1000
MKPKKQYRRK LREEFVFIPA AALDLFDYML ALDPSKRCTA EQALQCEFLR
1010 1020 1030 1040 1050
DVEPSKMPPP DLPLWQDCHE LWSKKRRRQK QMGMTDDVST VKAPRKDLSL
1060 1070 1080 1090 1100
GMDDSRTSTP QSVLPSSQLK PQGNSNAAPV KTGPGQQLNH SELAILLNLL
1110 1120 1130 1140 1150
QSKTSVNMAD FVQVLNIKVN SETQQQLNKI NLPAGILATG EKQTDPSTPQ
1160 1170 1180 1190 1200
QESSKPLGGI QPSQNMQPKV EPDAAQAAVQ SAFAVLLTQL IKAQQSKQKD
1210 1220 1230 1240 1250
VLLEERENGS GHEAPLQLRP PPEPATPASG QDDLIQHQDM RLLELTPEPD
1260 1270 1280 1290 1300
RPRILPPDQR PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA
1310 1320 1330 1340 1350
ALLQLLAQHQ PQDDPKRESG IDYQAGDTYV PSSDYKDNFG SSSFSSAPYV
1360 1370 1380 1390 1400
SNDGLGSASA PPLERRSFMG NSDIQSLDNY STTSSHSGGP PQPSAFSESF
1410 1420 1430 1440 1450
PSSVAGYGDI YLNTGPMLFS GDKDHRFEYS HGPIAVLANS SDPSTGPEST
1460 1470 1480 1490 1500
HPLPAKMHNY NYGGSLQETP GGHGLMHGQT WTSPAQGPGY SQGYRGHIST
1510
SAGRGRGRGL PY
Length:1,512
Mass (Da):164,717
Last modified:November 2, 2010 - v1
Checksum:i1DADA7AB73EA471B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03029660 Genomic DNA. No translation available.
AAFC03047979 Genomic DNA. No translation available.
RefSeqiNP_001192360.1. NM_001205431.1.
UniGeneiBt.31651.

Genome annotation databases

EnsembliENSBTAT00000002003; ENSBTAP00000002003; ENSBTAG00000001528.
GeneIDi511147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03029660 Genomic DNA. No translation available.
AAFC03047979 Genomic DNA. No translation available.
RefSeqiNP_001192360.1. NM_001205431.1.
UniGeneiBt.31651.

3D structure databases

ProteinModelPortaliE1BB52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002003.

Proteomic databases

PaxDbiE1BB52.
PRIDEiE1BB52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002003; ENSBTAP00000002003; ENSBTAG00000001528.
GeneIDi511147.

Organism-specific databases

CTDi8621.

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
InParanoidiE1BB52.
OMAiNVAPVKT.
OrthoDBiEOG091G08Z8.
TreeFamiTF101060.

Enzyme and pathway databases

ReactomeiR-BTA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-BTA-6798695. Neutrophil degranulation.

Gene expression databases

BgeeiENSBTAG00000001528.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK13_BOVIN
AccessioniPrimary (citable) accession number: E1BB52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.