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E1BB52

- CDK13_BOVIN

UniProt

E1BB52 - CDK13_BOVIN

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Protein

Cyclin-dependent kinase 13

Gene

CDK13

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis (By similarity).By similarity

Catalytic activityi

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei735 – 7351ATPPROSITE-ProRule annotation
Active sitei838 – 8381Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi712 – 7209ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. poly(A) RNA binding Source: Ensembl
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB

GO - Biological processi

  1. alternative mRNA splicing, via spliceosome Source: UniProtKB
  2. hemopoiesis Source: UniProtKB
  3. phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 13 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13
Gene namesi
Name:CDK13
Synonyms:CDC2L, CDC2L5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

Nucleus speckle By similarity

GO - Cellular componenti

  1. cyclin K-CDK13 complex Source: Ensembl
  2. extracellular space Source: Ensembl
  3. nuclear cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  4. nuclear speck Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15121512Cyclin-dependent kinase 13PRO_0000406956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei316 – 3161PhosphoserineBy similarity
Modified residuei318 – 3181PhosphoserineBy similarity
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei341 – 3411PhosphoserineBy similarity
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei396 – 3961PhosphoserineBy similarity
Modified residuei398 – 3981PhosphoserineBy similarity
Modified residuei401 – 4011PhosphoserineBy similarity
Modified residuei438 – 4381PhosphoserineBy similarity
Modified residuei440 – 4401PhosphoserineBy similarity
Modified residuei526 – 5261PhosphoserineBy similarity
Modified residuei557 – 5571N6-acetyllysineBy similarity
Modified residuei872 – 8721PhosphothreonineBy similarity
Modified residuei1049 – 10491PhosphoserineBy similarity
Modified residuei1246 – 12461PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiE1BB52.

Interactioni

Subunit structurei

Interacts with CCNK, CCNL1 and CCNL2. Interacts with C1QBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliE1BB52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini706 – 999294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 145Poly-Gly
Compositional biasi34 – 5724Pro-richAdd
BLAST
Compositional biasi62 – 7615Ala-richAdd
BLAST
Compositional biasi130 – 256127Gly-richAdd
BLAST
Compositional biasi248 – 449202Ser-richAdd
BLAST
Compositional biasi451 – 49141Ala-richAdd
BLAST
Compositional biasi1215 – 126955Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119290.
InParanoidiE1BB52.
KOiK08819.
OMAiKERHREH.
OrthoDBiEOG76DTSM.
TreeFamiTF101060.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BB52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ
60 70 80 90 100
PPPPPPPLLF LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG
110 120 130 140 150
GRQKRRRGPR AGQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS
160 170 180 190 200
SQSEQGLLLG GASAATAATA AGGTGGSGGS PASSSGTQRR GEGSERRPRR
210 220 230 240 250
DRRSSSGRSK DRHREHRRRD GQRGGGEASK SRSRHGHGGE ERAEAGKSGS
260 270 280 290 300
SSSSGGRRKS ASATSSSSSS RKDRDPKAHR SRTKSSKEPP SAYKEPPKAY
310 320 330 340 350
REDKTEPKAY RRRQRSLSPL GGRDDSPVSH RASQSLRNRK SPSPAGGGSS
360 370 380 390 400
PYSRRLARSP SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY
410 420 430 440 450
SPVIRRSAKS RSRSPYSSRH SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL
460 470 480 490 500
AAELNKNKKA RAAEAARAAE AAKAAEAAKA AEAAAKAAKA ASTSTPTKGN
510 520 530 540 550
TETGASASQT NHVKDVKKLK TEHAPSPSSG GTLKNDKAKT KPPLQVTKVD
560 570 580 590 600
NNLIVDKATK KAVVVGKESK SAATKEEPVS LKEKTKPLTP SIGAKEKEQH
610 620 630 640 650
VALVTSTLPP LPLPPMLPED KDADSLRGNI SVKAVKKEVE KKLRCLLADL
660 670 680 690 700
PLPPELPGGD DLSKSPEEKK TATQLHNKRR PKICGPRFGE IKEKDIDWGK
710 720 730 740 750
RCVDKFDIIG IIGEGTYGQV YKARDKDTGE MVALKKVRLD NEKEGFPITA
760 770 780 790 800
IREIKILRQL THQSIINMKE IVTDKEDALD FKKDKGAFYL VFEYMDHDLM
810 820 830 840 850
GLLESGLVHF NENHIKSFMR QLMEGLDYCH KKNFLHRDIK CSNILLNNRG
860 870 880 890 900
QIKLADFGLA RLYSSEESRP YTNKVITLWY RPPELLLGEE RYTPAIDVWS
910 920 930 940 950
CGCILGELFT KKPIFQANQE LAQLELISRI CGSPCPAVWP DVIKLPYFNT
960 970 980 990 1000
MKPKKQYRRK LREEFVFIPA AALDLFDYML ALDPSKRCTA EQALQCEFLR
1010 1020 1030 1040 1050
DVEPSKMPPP DLPLWQDCHE LWSKKRRRQK QMGMTDDVST VKAPRKDLSL
1060 1070 1080 1090 1100
GMDDSRTSTP QSVLPSSQLK PQGNSNAAPV KTGPGQQLNH SELAILLNLL
1110 1120 1130 1140 1150
QSKTSVNMAD FVQVLNIKVN SETQQQLNKI NLPAGILATG EKQTDPSTPQ
1160 1170 1180 1190 1200
QESSKPLGGI QPSQNMQPKV EPDAAQAAVQ SAFAVLLTQL IKAQQSKQKD
1210 1220 1230 1240 1250
VLLEERENGS GHEAPLQLRP PPEPATPASG QDDLIQHQDM RLLELTPEPD
1260 1270 1280 1290 1300
RPRILPPDQR PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA
1310 1320 1330 1340 1350
ALLQLLAQHQ PQDDPKRESG IDYQAGDTYV PSSDYKDNFG SSSFSSAPYV
1360 1370 1380 1390 1400
SNDGLGSASA PPLERRSFMG NSDIQSLDNY STTSSHSGGP PQPSAFSESF
1410 1420 1430 1440 1450
PSSVAGYGDI YLNTGPMLFS GDKDHRFEYS HGPIAVLANS SDPSTGPEST
1460 1470 1480 1490 1500
HPLPAKMHNY NYGGSLQETP GGHGLMHGQT WTSPAQGPGY SQGYRGHIST
1510
SAGRGRGRGL PY
Length:1,512
Mass (Da):164,717
Last modified:November 2, 2010 - v1
Checksum:i1DADA7AB73EA471B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFC03029660 Genomic DNA. No translation available.
AAFC03047979 Genomic DNA. No translation available.
RefSeqiNP_001192360.1. NM_001205431.1.
UniGeneiBt.31651.

Genome annotation databases

EnsembliENSBTAT00000002003; ENSBTAP00000002003; ENSBTAG00000001528.
GeneIDi511147.
KEGGibta:511147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFC03029660 Genomic DNA. No translation available.
AAFC03047979 Genomic DNA. No translation available.
RefSeqi NP_001192360.1. NM_001205431.1.
UniGenei Bt.31651.

3D structure databases

ProteinModelPortali E1BB52.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E1BB52.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002003 ; ENSBTAP00000002003 ; ENSBTAG00000001528 .
GeneIDi 511147.
KEGGi bta:511147.

Organism-specific databases

CTDi 8621.

Phylogenomic databases

GeneTreei ENSGT00760000119290.
InParanoidi E1BB52.
KOi K08819.
OMAi KERHREH.
OrthoDBi EOG76DTSM.
TreeFami TF101060.

Miscellaneous databases

NextBioi 20869798.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.

Entry informationi

Entry nameiCDK13_BOVIN
AccessioniPrimary (citable) accession number: E1BB52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3