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E1BB52

- CDK13_BOVIN

UniProt

E1BB52 - CDK13_BOVIN

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Protein
Cyclin-dependent kinase 13
Gene
CDK13, CDC2L, CDC2L5
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis By similarity.

Catalytic activityi

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei735 – 7351ATP By similarity
Active sitei838 – 8381Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi712 – 7209ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. alternative mRNA splicing, via spliceosome Source: UniProtKB
  2. hemopoiesis Source: UniProtKB
  3. phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 13 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13
Gene namesi
Name:CDK13
Synonyms:CDC2L, CDC2L5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

Nucleus speckle By similarity

GO - Cellular componenti

  1. cyclin K-CDK13 complex Source: Ensembl
  2. nuclear cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  3. nuclear speck Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15121512Cyclin-dependent kinase 13
PRO_0000406956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei316 – 3161Phosphoserine By similarity
Modified residuei318 – 3181Phosphoserine By similarity
Modified residuei326 – 3261Phosphoserine By similarity
Modified residuei341 – 3411Phosphoserine By similarity
Modified residuei343 – 3431Phosphoserine By similarity
Modified residuei384 – 3841Phosphoserine By similarity
Modified residuei396 – 3961Phosphoserine By similarity
Modified residuei398 – 3981Phosphoserine By similarity
Modified residuei401 – 4011Phosphoserine By similarity
Modified residuei438 – 4381Phosphoserine By similarity
Modified residuei440 – 4401Phosphoserine By similarity
Modified residuei526 – 5261Phosphoserine By similarity
Modified residuei557 – 5571N6-acetyllysine By similarity
Modified residuei872 – 8721Phosphothreonine By similarity
Modified residuei1049 – 10491Phosphoserine By similarity
Modified residuei1246 – 12461Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiE1BB52.

Interactioni

Subunit structurei

Interacts with CCNK, CCNL1 and CCNL2 By similarity. Interacts with C1QBP By similarity.

Structurei

3D structure databases

ProteinModelPortaliE1BB52.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini706 – 999294Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 145Poly-Gly
Compositional biasi34 – 5724Pro-rich
Add
BLAST
Compositional biasi62 – 7615Ala-rich
Add
BLAST
Compositional biasi130 – 256127Gly-rich
Add
BLAST
Compositional biasi248 – 449202Ser-rich
Add
BLAST
Compositional biasi451 – 49141Ala-rich
Add
BLAST
Compositional biasi1215 – 126955Pro-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00740000114964.
KOiK08819.
OMAiKERHREH.
OrthoDBiEOG76DTSM.
TreeFamiTF101060.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1BB52-1 [UniParc]FASTAAdd to Basket

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MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ     50
PPPPPPPLLF LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG 100
GRQKRRRGPR AGQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS 150
SQSEQGLLLG GASAATAATA AGGTGGSGGS PASSSGTQRR GEGSERRPRR 200
DRRSSSGRSK DRHREHRRRD GQRGGGEASK SRSRHGHGGE ERAEAGKSGS 250
SSSSGGRRKS ASATSSSSSS RKDRDPKAHR SRTKSSKEPP SAYKEPPKAY 300
REDKTEPKAY RRRQRSLSPL GGRDDSPVSH RASQSLRNRK SPSPAGGGSS 350
PYSRRLARSP SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY 400
SPVIRRSAKS RSRSPYSSRH SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL 450
AAELNKNKKA RAAEAARAAE AAKAAEAAKA AEAAAKAAKA ASTSTPTKGN 500
TETGASASQT NHVKDVKKLK TEHAPSPSSG GTLKNDKAKT KPPLQVTKVD 550
NNLIVDKATK KAVVVGKESK SAATKEEPVS LKEKTKPLTP SIGAKEKEQH 600
VALVTSTLPP LPLPPMLPED KDADSLRGNI SVKAVKKEVE KKLRCLLADL 650
PLPPELPGGD DLSKSPEEKK TATQLHNKRR PKICGPRFGE IKEKDIDWGK 700
RCVDKFDIIG IIGEGTYGQV YKARDKDTGE MVALKKVRLD NEKEGFPITA 750
IREIKILRQL THQSIINMKE IVTDKEDALD FKKDKGAFYL VFEYMDHDLM 800
GLLESGLVHF NENHIKSFMR QLMEGLDYCH KKNFLHRDIK CSNILLNNRG 850
QIKLADFGLA RLYSSEESRP YTNKVITLWY RPPELLLGEE RYTPAIDVWS 900
CGCILGELFT KKPIFQANQE LAQLELISRI CGSPCPAVWP DVIKLPYFNT 950
MKPKKQYRRK LREEFVFIPA AALDLFDYML ALDPSKRCTA EQALQCEFLR 1000
DVEPSKMPPP DLPLWQDCHE LWSKKRRRQK QMGMTDDVST VKAPRKDLSL 1050
GMDDSRTSTP QSVLPSSQLK PQGNSNAAPV KTGPGQQLNH SELAILLNLL 1100
QSKTSVNMAD FVQVLNIKVN SETQQQLNKI NLPAGILATG EKQTDPSTPQ 1150
QESSKPLGGI QPSQNMQPKV EPDAAQAAVQ SAFAVLLTQL IKAQQSKQKD 1200
VLLEERENGS GHEAPLQLRP PPEPATPASG QDDLIQHQDM RLLELTPEPD 1250
RPRILPPDQR PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA 1300
ALLQLLAQHQ PQDDPKRESG IDYQAGDTYV PSSDYKDNFG SSSFSSAPYV 1350
SNDGLGSASA PPLERRSFMG NSDIQSLDNY STTSSHSGGP PQPSAFSESF 1400
PSSVAGYGDI YLNTGPMLFS GDKDHRFEYS HGPIAVLANS SDPSTGPEST 1450
HPLPAKMHNY NYGGSLQETP GGHGLMHGQT WTSPAQGPGY SQGYRGHIST 1500
SAGRGRGRGL PY 1512
Length:1,512
Mass (Da):164,717
Last modified:November 2, 2010 - v1
Checksum:i1DADA7AB73EA471B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFC03029660 Genomic DNA. No translation available.
AAFC03047979 Genomic DNA. No translation available.
RefSeqiNP_001192360.1. NM_001205431.1.
UniGeneiBt.31651.

Genome annotation databases

EnsembliENSBTAT00000002003; ENSBTAP00000002003; ENSBTAG00000001528.
GeneIDi511147.
KEGGibta:511147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFC03029660 Genomic DNA. No translation available.
AAFC03047979 Genomic DNA. No translation available.
RefSeqi NP_001192360.1. NM_001205431.1.
UniGenei Bt.31651.

3D structure databases

ProteinModelPortali E1BB52.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E1BB52.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002003 ; ENSBTAP00000002003 ; ENSBTAG00000001528 .
GeneIDi 511147.
KEGGi bta:511147.

Organism-specific databases

CTDi 8621.

Phylogenomic databases

GeneTreei ENSGT00740000114964.
KOi K08819.
OMAi KERHREH.
OrthoDBi EOG76DTSM.
TreeFami TF101060.

Miscellaneous databases

NextBioi 20869798.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.

Entry informationi

Entry nameiCDK13_BOVIN
AccessioniPrimary (citable) accession number: E1BB52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: November 2, 2010
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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