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E1BB52

- CDK13_BOVIN

UniProt

E1BB52 - CDK13_BOVIN

Protein

Cyclin-dependent kinase 13

Gene

CDK13

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis By similarity.By similarity

    Catalytic activityi

    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei735 – 7351ATPPROSITE-ProRule annotation
    Active sitei838 – 8381Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi712 – 7209ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB

    GO - Biological processi

    1. alternative mRNA splicing, via spliceosome Source: UniProtKB
    2. hemopoiesis Source: UniProtKB
    3. phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 13 (EC:2.7.11.22, EC:2.7.11.23)
    Alternative name(s):
    CDC2-related protein kinase 5
    Cell division cycle 2-like protein kinase 5
    Cell division protein kinase 13
    Gene namesi
    Name:CDK13
    Synonyms:CDC2L, CDC2L5
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    Nucleus speckle By similarity

    GO - Cellular componenti

    1. cyclin K-CDK13 complex Source: Ensembl
    2. nuclear cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
    3. nuclear speck Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15121512Cyclin-dependent kinase 13PRO_0000406956Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei316 – 3161PhosphoserineBy similarity
    Modified residuei318 – 3181PhosphoserineBy similarity
    Modified residuei326 – 3261PhosphoserineBy similarity
    Modified residuei341 – 3411PhosphoserineBy similarity
    Modified residuei343 – 3431PhosphoserineBy similarity
    Modified residuei384 – 3841PhosphoserineBy similarity
    Modified residuei396 – 3961PhosphoserineBy similarity
    Modified residuei398 – 3981PhosphoserineBy similarity
    Modified residuei401 – 4011PhosphoserineBy similarity
    Modified residuei438 – 4381PhosphoserineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity
    Modified residuei526 – 5261PhosphoserineBy similarity
    Modified residuei557 – 5571N6-acetyllysineBy similarity
    Modified residuei872 – 8721PhosphothreonineBy similarity
    Modified residuei1049 – 10491PhosphoserineBy similarity
    Modified residuei1246 – 12461PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiE1BB52.

    Interactioni

    Subunit structurei

    Interacts with CCNK, CCNL1 and CCNL2. Interacts with C1QBP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliE1BB52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini706 – 999294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 145Poly-Gly
    Compositional biasi34 – 5724Pro-richAdd
    BLAST
    Compositional biasi62 – 7615Ala-richAdd
    BLAST
    Compositional biasi130 – 256127Gly-richAdd
    BLAST
    Compositional biasi248 – 449202Ser-richAdd
    BLAST
    Compositional biasi451 – 49141Ala-richAdd
    BLAST
    Compositional biasi1215 – 126955Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114964.
    KOiK08819.
    OMAiKERHREH.
    OrthoDBiEOG76DTSM.
    TreeFamiTF101060.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1BB52-1 [UniParc]FASTAAdd to Basket

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    MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ     50
    PPPPPPPLLF LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG 100
    GRQKRRRGPR AGQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS 150
    SQSEQGLLLG GASAATAATA AGGTGGSGGS PASSSGTQRR GEGSERRPRR 200
    DRRSSSGRSK DRHREHRRRD GQRGGGEASK SRSRHGHGGE ERAEAGKSGS 250
    SSSSGGRRKS ASATSSSSSS RKDRDPKAHR SRTKSSKEPP SAYKEPPKAY 300
    REDKTEPKAY RRRQRSLSPL GGRDDSPVSH RASQSLRNRK SPSPAGGGSS 350
    PYSRRLARSP SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY 400
    SPVIRRSAKS RSRSPYSSRH SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL 450
    AAELNKNKKA RAAEAARAAE AAKAAEAAKA AEAAAKAAKA ASTSTPTKGN 500
    TETGASASQT NHVKDVKKLK TEHAPSPSSG GTLKNDKAKT KPPLQVTKVD 550
    NNLIVDKATK KAVVVGKESK SAATKEEPVS LKEKTKPLTP SIGAKEKEQH 600
    VALVTSTLPP LPLPPMLPED KDADSLRGNI SVKAVKKEVE KKLRCLLADL 650
    PLPPELPGGD DLSKSPEEKK TATQLHNKRR PKICGPRFGE IKEKDIDWGK 700
    RCVDKFDIIG IIGEGTYGQV YKARDKDTGE MVALKKVRLD NEKEGFPITA 750
    IREIKILRQL THQSIINMKE IVTDKEDALD FKKDKGAFYL VFEYMDHDLM 800
    GLLESGLVHF NENHIKSFMR QLMEGLDYCH KKNFLHRDIK CSNILLNNRG 850
    QIKLADFGLA RLYSSEESRP YTNKVITLWY RPPELLLGEE RYTPAIDVWS 900
    CGCILGELFT KKPIFQANQE LAQLELISRI CGSPCPAVWP DVIKLPYFNT 950
    MKPKKQYRRK LREEFVFIPA AALDLFDYML ALDPSKRCTA EQALQCEFLR 1000
    DVEPSKMPPP DLPLWQDCHE LWSKKRRRQK QMGMTDDVST VKAPRKDLSL 1050
    GMDDSRTSTP QSVLPSSQLK PQGNSNAAPV KTGPGQQLNH SELAILLNLL 1100
    QSKTSVNMAD FVQVLNIKVN SETQQQLNKI NLPAGILATG EKQTDPSTPQ 1150
    QESSKPLGGI QPSQNMQPKV EPDAAQAAVQ SAFAVLLTQL IKAQQSKQKD 1200
    VLLEERENGS GHEAPLQLRP PPEPATPASG QDDLIQHQDM RLLELTPEPD 1250
    RPRILPPDQR PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA 1300
    ALLQLLAQHQ PQDDPKRESG IDYQAGDTYV PSSDYKDNFG SSSFSSAPYV 1350
    SNDGLGSASA PPLERRSFMG NSDIQSLDNY STTSSHSGGP PQPSAFSESF 1400
    PSSVAGYGDI YLNTGPMLFS GDKDHRFEYS HGPIAVLANS SDPSTGPEST 1450
    HPLPAKMHNY NYGGSLQETP GGHGLMHGQT WTSPAQGPGY SQGYRGHIST 1500
    SAGRGRGRGL PY 1512
    Length:1,512
    Mass (Da):164,717
    Last modified:November 2, 2010 - v1
    Checksum:i1DADA7AB73EA471B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03029660 Genomic DNA. No translation available.
    AAFC03047979 Genomic DNA. No translation available.
    RefSeqiNP_001192360.1. NM_001205431.1.
    UniGeneiBt.31651.

    Genome annotation databases

    EnsembliENSBTAT00000002003; ENSBTAP00000002003; ENSBTAG00000001528.
    GeneIDi511147.
    KEGGibta:511147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03029660 Genomic DNA. No translation available.
    AAFC03047979 Genomic DNA. No translation available.
    RefSeqi NP_001192360.1. NM_001205431.1.
    UniGenei Bt.31651.

    3D structure databases

    ProteinModelPortali E1BB52.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E1BB52.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002003 ; ENSBTAP00000002003 ; ENSBTAG00000001528 .
    GeneIDi 511147.
    KEGGi bta:511147.

    Organism-specific databases

    CTDi 8621.

    Phylogenomic databases

    GeneTreei ENSGT00740000114964.
    KOi K08819.
    OMAi KERHREH.
    OrthoDBi EOG76DTSM.
    TreeFami TF101060.

    Miscellaneous databases

    NextBioi 20869798.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
      The bovine genome sequencing and analysis consortium
      Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.

    Entry informationi

    Entry nameiCDK13_BOVIN
    AccessioniPrimary (citable) accession number: E1BB52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3