Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E1BB52 (CDK13_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 13

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13
Gene names
Name:CDK13
Synonyms:CDC2L, CDC2L5
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length1512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis By similarity.

Catalytic activity

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with CCNL1 and CCNL2 By similarity. Interacts with C1QBP By similarity.

Subcellular location

Nucleus speckle By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15121512Cyclin-dependent kinase 13
PRO_0000406956

Regions

Domain706 – 999294Protein kinase
Nucleotide binding712 – 7209ATP By similarity
Compositional bias10 – 145Poly-Gly
Compositional bias34 – 5724Pro-rich
Compositional bias62 – 7615Ala-rich
Compositional bias130 – 256127Gly-rich
Compositional bias248 – 449202Ser-rich
Compositional bias451 – 49141Ala-rich
Compositional bias1215 – 126955Pro-rich

Sites

Active site8381Proton acceptor By similarity
Binding site7351ATP By similarity

Amino acid modifications

Modified residue3161Phosphoserine By similarity
Modified residue3181Phosphoserine By similarity
Modified residue3261Phosphoserine By similarity
Modified residue3411Phosphoserine By similarity
Modified residue3431Phosphoserine By similarity
Modified residue3841Phosphoserine By similarity
Modified residue3961Phosphoserine By similarity
Modified residue3981Phosphoserine By similarity
Modified residue4011Phosphoserine By similarity
Modified residue4381Phosphoserine By similarity
Modified residue4401Phosphoserine By similarity
Modified residue5261Phosphoserine By similarity
Modified residue5571N6-acetyllysine By similarity
Modified residue8721Phosphothreonine By similarity
Modified residue10491Phosphoserine By similarity
Modified residue12461Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
E1BB52 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 1DADA7AB73EA471B

FASTA1,512164,717
        10         20         30         40         50         60 
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 

        70         80         90        100        110        120 
LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG GRQKRRRGPR AGQEAEKRRV 

       130        140        150        160        170        180 
FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGSGGS 

       190        200        210        220        230        240 
PASSSGTQRR GEGSERRPRR DRRSSSGRSK DRHREHRRRD GQRGGGEASK SRSRHGHGGE 

       250        260        270        280        290        300 
ERAEAGKSGS SSSSGGRRKS ASATSSSSSS RKDRDPKAHR SRTKSSKEPP SAYKEPPKAY 

       310        320        330        340        350        360 
REDKTEPKAY RRRQRSLSPL GGRDDSPVSH RASQSLRNRK SPSPAGGGSS PYSRRLARSP 

       370        380        390        400        410        420 
SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY SPVIRRSAKS RSRSPYSSRH 

       430        440        450        460        470        480 
SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL AAELNKNKKA RAAEAARAAE AAKAAEAAKA 

       490        500        510        520        530        540 
AEAAAKAAKA ASTSTPTKGN TETGASASQT NHVKDVKKLK TEHAPSPSSG GTLKNDKAKT 

       550        560        570        580        590        600 
KPPLQVTKVD NNLIVDKATK KAVVVGKESK SAATKEEPVS LKEKTKPLTP SIGAKEKEQH 

       610        620        630        640        650        660 
VALVTSTLPP LPLPPMLPED KDADSLRGNI SVKAVKKEVE KKLRCLLADL PLPPELPGGD 

       670        680        690        700        710        720 
DLSKSPEEKK TATQLHNKRR PKICGPRFGE IKEKDIDWGK RCVDKFDIIG IIGEGTYGQV 

       730        740        750        760        770        780 
YKARDKDTGE MVALKKVRLD NEKEGFPITA IREIKILRQL THQSIINMKE IVTDKEDALD 

       790        800        810        820        830        840 
FKKDKGAFYL VFEYMDHDLM GLLESGLVHF NENHIKSFMR QLMEGLDYCH KKNFLHRDIK 

       850        860        870        880        890        900 
CSNILLNNRG QIKLADFGLA RLYSSEESRP YTNKVITLWY RPPELLLGEE RYTPAIDVWS 

       910        920        930        940        950        960 
CGCILGELFT KKPIFQANQE LAQLELISRI CGSPCPAVWP DVIKLPYFNT MKPKKQYRRK 

       970        980        990       1000       1010       1020 
LREEFVFIPA AALDLFDYML ALDPSKRCTA EQALQCEFLR DVEPSKMPPP DLPLWQDCHE 

      1030       1040       1050       1060       1070       1080 
LWSKKRRRQK QMGMTDDVST VKAPRKDLSL GMDDSRTSTP QSVLPSSQLK PQGNSNAAPV 

      1090       1100       1110       1120       1130       1140 
KTGPGQQLNH SELAILLNLL QSKTSVNMAD FVQVLNIKVN SETQQQLNKI NLPAGILATG 

      1150       1160       1170       1180       1190       1200 
EKQTDPSTPQ QESSKPLGGI QPSQNMQPKV EPDAAQAAVQ SAFAVLLTQL IKAQQSKQKD 

      1210       1220       1230       1240       1250       1260 
VLLEERENGS GHEAPLQLRP PPEPATPASG QDDLIQHQDM RLLELTPEPD RPRILPPDQR 

      1270       1280       1290       1300       1310       1320 
PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA ALLQLLAQHQ PQDDPKRESG 

      1330       1340       1350       1360       1370       1380 
IDYQAGDTYV PSSDYKDNFG SSSFSSAPYV SNDGLGSASA PPLERRSFMG NSDIQSLDNY 

      1390       1400       1410       1420       1430       1440 
STTSSHSGGP PQPSAFSESF PSSVAGYGDI YLNTGPMLFS GDKDHRFEYS HGPIAVLANS 

      1450       1460       1470       1480       1490       1500 
SDPSTGPEST HPLPAKMHNY NYGGSLQETP GGHGLMHGQT WTSPAQGPGY SQGYRGHIST 

      1510 
SAGRGRGRGL PY 

« Hide

References

[1]"The genome sequence of taurine cattle: a window to ruminant biology and evolution."
The bovine genome sequencing and analysis consortium
Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFC03029660 Genomic DNA. No translation available.
AAFC03047979 Genomic DNA. No translation available.
RefSeqNP_001192360.1. NM_001205431.1.
UniGeneBt.31651.

3D structure databases

ProteinModelPortalE1BB52.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEE1BB52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002003; ENSBTAP00000002003; ENSBTAG00000001528.
GeneID511147.
KEGGbta:511147.

Organism-specific databases

CTD8621.

Phylogenomic databases

GeneTreeENSGT00740000114964.
KOK08819.
OMANVAPVKT.
OrthoDBEOG76DTSM.
TreeFamTF101060.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20869798.

Entry information

Entry nameCDK13_BOVIN
AccessionPrimary (citable) accession number: E1BB52
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families