Cyclin-dependent kinase 13 - Bos taurus (Bovine)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 13
EC=2.7.11.22
EC=2.7.11.23

Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13

Gene names

Name:	CDK13
Synonyms:	CDC2L, CDC2L5

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	1512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis By similarity.
Catalytic activity	ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with CCNL1 and CCNL2 By similarity. Interacts with C1QBP By similarity.
Subcellular location	Nucleus speckle By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	alternative mRNA splicing, via spliceosome Inferred from sequence or structural similarity. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: GOC hemopoiesis Inferred from sequence or structural similarity. Source: UniProtKB phosphorylation of RNA polymerase II C-terminal domain Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	nuclear cyclin-dependent protein kinase holoenzyme complex Inferred from sequence or structural similarity. Source: UniProtKB nuclear speck Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from sequence or structural similarity. Source: UniProtKB cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1512

1512

Cyclin-dependent kinase 13

PRO_0000406956

Regions

Domain

706 – 999

294

Protein kinase

Nucleotide binding

712 – 720

9

ATP By similarity

Compositional bias

10 – 14

5

Poly-Gly

Compositional bias

34 – 57

24

Pro-rich

Compositional bias

62 – 76

15

Ala-rich

Compositional bias

130 – 256

127

Gly-rich

Compositional bias

248 – 449

202

Ser-rich

Compositional bias

451 – 491

41

Ala-rich

Compositional bias

1215 – 1269

55

Pro-rich

Sites

Active site

838

1

Proton acceptor By similarity

Binding site

735

1

ATP By similarity

Amino acid modifications

Modified residue

316

1

Phosphoserine By similarity

Modified residue

318

1

Phosphoserine By similarity

Modified residue

326

1

Phosphoserine By similarity

Modified residue

341

1

Phosphoserine By similarity

Modified residue

343

1

Phosphoserine By similarity

Modified residue

384

1

Phosphoserine By similarity

Modified residue

396

1

Phosphoserine By similarity

Modified residue

398

1

Phosphoserine By similarity

Modified residue

401

1

Phosphoserine By similarity

Modified residue

410

1

Phosphoserine By similarity

Modified residue

437

1

Phosphoserine By similarity

Modified residue

438

1

Phosphoserine By similarity

Modified residue

440

1

Phosphoserine By similarity

Modified residue

526

1

Phosphoserine By similarity

Modified residue

557

1

N6-acetyllysine By similarity

Modified residue

872

1

Phosphothreonine By similarity

Modified residue

1049

1

Phosphoserine By similarity

Modified residue

1246

1

Phosphothreonine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

E1BB52 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 1DADA7AB73EA471B
Show »

FASTA

1,512

164,717

        10         20         30         40         50         60 
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 

        70         80         90        100        110        120 
LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG GRQKRRRGPR AGQEAEKRRV 

       130        140        150        160        170        180 
FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGSGGS 

       190        200        210        220        230        240 
PASSSGTQRR GEGSERRPRR DRRSSSGRSK DRHREHRRRD GQRGGGEASK SRSRHGHGGE 

       250        260        270        280        290        300 
ERAEAGKSGS SSSSGGRRKS ASATSSSSSS RKDRDPKAHR SRTKSSKEPP SAYKEPPKAY 

       310        320        330        340        350        360 
REDKTEPKAY RRRQRSLSPL GGRDDSPVSH RASQSLRNRK SPSPAGGGSS PYSRRLARSP 

       370        380        390        400        410        420 
SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY SPVIRRSAKS RSRSPYSSRH 

       430        440        450        460        470        480 
SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL AAELNKNKKA RAAEAARAAE AAKAAEAAKA 

       490        500        510        520        530        540 
AEAAAKAAKA ASTSTPTKGN TETGASASQT NHVKDVKKLK TEHAPSPSSG GTLKNDKAKT 

       550        560        570        580        590        600 
KPPLQVTKVD NNLIVDKATK KAVVVGKESK SAATKEEPVS LKEKTKPLTP SIGAKEKEQH 

       610        620        630        640        650        660 
VALVTSTLPP LPLPPMLPED KDADSLRGNI SVKAVKKEVE KKLRCLLADL PLPPELPGGD 

       670        680        690        700        710        720 
DLSKSPEEKK TATQLHNKRR PKICGPRFGE IKEKDIDWGK RCVDKFDIIG IIGEGTYGQV 

       730        740        750        760        770        780 
YKARDKDTGE MVALKKVRLD NEKEGFPITA IREIKILRQL THQSIINMKE IVTDKEDALD 

       790        800        810        820        830        840 
FKKDKGAFYL VFEYMDHDLM GLLESGLVHF NENHIKSFMR QLMEGLDYCH KKNFLHRDIK 

       850        860        870        880        890        900 
CSNILLNNRG QIKLADFGLA RLYSSEESRP YTNKVITLWY RPPELLLGEE RYTPAIDVWS 

       910        920        930        940        950        960 
CGCILGELFT KKPIFQANQE LAQLELISRI CGSPCPAVWP DVIKLPYFNT MKPKKQYRRK 

       970        980        990       1000       1010       1020 
LREEFVFIPA AALDLFDYML ALDPSKRCTA EQALQCEFLR DVEPSKMPPP DLPLWQDCHE 

      1030       1040       1050       1060       1070       1080 
LWSKKRRRQK QMGMTDDVST VKAPRKDLSL GMDDSRTSTP QSVLPSSQLK PQGNSNAAPV 

      1090       1100       1110       1120       1130       1140 
KTGPGQQLNH SELAILLNLL QSKTSVNMAD FVQVLNIKVN SETQQQLNKI NLPAGILATG 

      1150       1160       1170       1180       1190       1200 
EKQTDPSTPQ QESSKPLGGI QPSQNMQPKV EPDAAQAAVQ SAFAVLLTQL IKAQQSKQKD 

      1210       1220       1230       1240       1250       1260 
VLLEERENGS GHEAPLQLRP PPEPATPASG QDDLIQHQDM RLLELTPEPD RPRILPPDQR 

      1270       1280       1290       1300       1310       1320 
PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA ALLQLLAQHQ PQDDPKRESG 

      1330       1340       1350       1360       1370       1380 
IDYQAGDTYV PSSDYKDNFG SSSFSSAPYV SNDGLGSASA PPLERRSFMG NSDIQSLDNY 

      1390       1400       1410       1420       1430       1440 
STTSSHSGGP PQPSAFSESF PSSVAGYGDI YLNTGPMLFS GDKDHRFEYS HGPIAVLANS 

      1450       1460       1470       1480       1490       1500 
SDPSTGPEST HPLPAKMHNY NYGGSLQETP GGHGLMHGQT WTSPAQGPGY SQGYRGHIST 

      1510 
SAGRGRGRGL PY

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References

[1]	"The genome sequence of taurine cattle: a window to ruminant biology and evolution." The bovine genome sequencing and analysis consortium Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hereford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFC03029660 Genomic DNA. No translation available. AAFC03047979 Genomic DNA. No translation available.
IPI	IPI00824204.
RefSeq	NP_001192360.1. NM_001205431.1.
UniGene	Bt.31651.
3D structure databases
ProteinModelPortal	E1BB52.
ModBase	Search...
Proteomic databases
PRIDE	E1BB52.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000002003; ENSBTAP00000002003; ENSBTAG00000001528.
GeneID	511147.
KEGG	bta:511147.
Organism-specific databases
CTD	8621.
Phylogenomic databases
GeneTree	ENSGT00690000102025.
KO	K08819.
OMA	KERHREH.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20869798.

Entry information

Entry name

CDK13_BOVIN

Accession

Primary (citable) accession number: E1BB52

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents