Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E1B9W9 (UBP42_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 42

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene names
Name:USP42
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length1333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinating enzyme which may play an important role during spermatogenesis By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13331333Ubiquitin carboxyl-terminal hydrolase 42
PRO_0000404198

Regions

Domain111 – 412302USP
Compositional bias64 – 674Poly-Ser
Compositional bias952 – 1126175Arg-rich
Compositional bias1185 – 125571Lys-rich

Sites

Active site1201Nucleophile By similarity
Active site3711Proton acceptor By similarity

Amino acid modifications

Modified residue8631Phosphoserine By similarity
Modified residue12351Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
E1B9W9 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 8E638010675EA919

FASTA1,333146,748
        10         20         30         40         50         60 
MTIVDKASES SDPSTYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA 

        70         80         90        100        110        120 
VVYSSSSVPE KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC 

       130        140        150        160        170        180 
FANAALQCLT YTPPLANYML SHEHSKTCHA EGFCMMCTMQ AHITQALSNP GDVIKPMFVI 

       190        200        210        220        230        240 
NEMRRIARHF RFGNQEDAHE FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS 

       250        260        270        280        290        300 
RVKCLNCKGV SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA 

       310        320        330        340        350        360 
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE PIIYVLYAVL 

       370        380        390        400        410        420 
VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL SQQAYVLFYI RSHDVKNGGE 

       430        440        450        460        470        480 
LTHSAHSPGQ SSPRPVISQR VVNSKQAASG FIGPQLPSHM MKNPPHLNGT GPLKETPSSP 

       490        500        510        520        530        540 
MSGPSGNSSV SRTGPVSASP SVQNWSVNRP SVIPEHPKKQ KITISIHNKL PVRQGQSQSN 

       550        560        570        580        590        600 
LHSNSLEHPN KPAPSSTITT SSAIQSTSSA PTPPASSKVP KQMAPREACS RPMMNGRPRL 

       610        620        630        640        650        660 
SAGVLVPYGA ESSEESDEEA KGLGQENGRG LTESACSPAL DAEDGDASPH ELQEPVALNG 

       670        680        690        700        710        720 
ATGLDSDPTE NGLPSDGAPC PGQPALHSEH PFPKANGLPG KLMPAPLPPL PEDKILETFK 

       730        740        750        760        770        780 
LGSKAKGSAE ETRTPGSEER PLEHPEAELE AGRSPPGDAR DNLESVSNLS SKFKKASPPS 

       790        800        810        820        830        840 
DPSIKPTKEE VSERVSAEPE EAVPSASTFC NPDKDALGDD QLLAPCDPGN LTDDQSKPSP 

       850        860        870        880        890        900 
DVGGTLPERP QDPVAAEAAG RLSPGPSVPS EGDHEPEPLG HSGRDRGSDA EGPSKSMGVS 

       910        920        930        940        950        960 
TDEAPSAQLD TITENRPEGP PERSSSERGE DSKAGQKAPE PCLVQEKVSS LRKVDRGHYR 

       970        980        990       1000       1010       1020 
SRRDRSSSGE HARESRSRTE VQHRRKRPHR EHERPRPERP RPEPCALAPQ PPCPSSLARS 

      1030       1040       1050       1060       1070       1080 
GHHHSRSRGA PDQEWGRYHH AEGDHAWTRE KYYPDRLRWE RCRYHHDRSP LYPSREPRDW 

      1090       1100       1110       1120       1130       1140 
RPFHAEREYE RAGPYGGRPY KDHYRGRKGY ELVAKERDRH RFSSPRAGMA HAPPPHPAAK 

      1150       1160       1170       1180       1190       1200 
YTHDRLSFGA EDGSCDLAAR FHEHDNIKSR KRRYDSLENE SHVEKKAWRS LQKDPVEEPK 

      1210       1220       1230       1240       1250       1260 
VKKHKKSKKK KKSKDKHRDR DSRHQQDSDL SVAHSDADLH RHKKKKKKKK RHSRKSEDFG 

      1270       1280       1290       1300       1310       1320 
RDSEPRLPKA ASCETVDHFR KAEGAFPLAD GLPLEGAAPF CEKTKHFRME SREVRCRLSQ 

      1330 
CDQGKGARWE SGS 

« Hide

References

[1]"The genome sequence of taurine cattle: a window to ruminant biology and evolution."
The bovine genome sequencing and analysis consortium
Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFC03050082 Genomic DNA. No translation available.
UniGeneBt.42050.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000967; ENSBTAP00000000967; ENSBTAG00000000725.

Phylogenomic databases

GeneTreeENSGT00750000117288.
OMAGKLMPAP.
OrthoDBEOG72VH5K.
TreeFamTF315281.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP42_BOVIN
AccessionPrimary (citable) accession number: E1B9W9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries