Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E1B9W9

- UBP42_BOVIN

UniProt

E1B9W9 - UBP42_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

USP42

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei120 – 1201NucleophilePROSITE-ProRule annotation
Active sitei371 – 3711Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: Ensembl

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. protein deubiquitination Source: UniProtKB
  3. spermatogenesis Source: UniProtKB-KW
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:USP42
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333Ubiquitin carboxyl-terminal hydrolase 42PRO_0000404198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei863 – 8631PhosphoserineBy similarity
Modified residuei1235 – 12351PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 412302USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 674Poly-Ser
Compositional biasi952 – 1126175Arg-richAdd
BLAST
Compositional biasi1185 – 125571Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119279.
InParanoidiE1B9W9.
OMAiGKLMPAP.
OrthoDBiEOG72VH5K.
TreeFamiTF315281.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1B9W9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIVDKASES SDPSTYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH
60 70 80 90 100
TLSLGPVPGA VVYSSSSVPE KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC
110 120 130 140 150
LKWQQTHRVG AGLQNLGNTC FANAALQCLT YTPPLANYML SHEHSKTCHA
160 170 180 190 200
EGFCMMCTMQ AHITQALSNP GDVIKPMFVI NEMRRIARHF RFGNQEDAHE
210 220 230 240 250
FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS RVKCLNCKGV
260 270 280 290 300
SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA
310 320 330 340 350
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE
360 370 380 390 400
PIIYVLYAVL VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL
410 420 430 440 450
SQQAYVLFYI RSHDVKNGGE LTHSAHSPGQ SSPRPVISQR VVNSKQAASG
460 470 480 490 500
FIGPQLPSHM MKNPPHLNGT GPLKETPSSP MSGPSGNSSV SRTGPVSASP
510 520 530 540 550
SVQNWSVNRP SVIPEHPKKQ KITISIHNKL PVRQGQSQSN LHSNSLEHPN
560 570 580 590 600
KPAPSSTITT SSAIQSTSSA PTPPASSKVP KQMAPREACS RPMMNGRPRL
610 620 630 640 650
SAGVLVPYGA ESSEESDEEA KGLGQENGRG LTESACSPAL DAEDGDASPH
660 670 680 690 700
ELQEPVALNG ATGLDSDPTE NGLPSDGAPC PGQPALHSEH PFPKANGLPG
710 720 730 740 750
KLMPAPLPPL PEDKILETFK LGSKAKGSAE ETRTPGSEER PLEHPEAELE
760 770 780 790 800
AGRSPPGDAR DNLESVSNLS SKFKKASPPS DPSIKPTKEE VSERVSAEPE
810 820 830 840 850
EAVPSASTFC NPDKDALGDD QLLAPCDPGN LTDDQSKPSP DVGGTLPERP
860 870 880 890 900
QDPVAAEAAG RLSPGPSVPS EGDHEPEPLG HSGRDRGSDA EGPSKSMGVS
910 920 930 940 950
TDEAPSAQLD TITENRPEGP PERSSSERGE DSKAGQKAPE PCLVQEKVSS
960 970 980 990 1000
LRKVDRGHYR SRRDRSSSGE HARESRSRTE VQHRRKRPHR EHERPRPERP
1010 1020 1030 1040 1050
RPEPCALAPQ PPCPSSLARS GHHHSRSRGA PDQEWGRYHH AEGDHAWTRE
1060 1070 1080 1090 1100
KYYPDRLRWE RCRYHHDRSP LYPSREPRDW RPFHAEREYE RAGPYGGRPY
1110 1120 1130 1140 1150
KDHYRGRKGY ELVAKERDRH RFSSPRAGMA HAPPPHPAAK YTHDRLSFGA
1160 1170 1180 1190 1200
EDGSCDLAAR FHEHDNIKSR KRRYDSLENE SHVEKKAWRS LQKDPVEEPK
1210 1220 1230 1240 1250
VKKHKKSKKK KKSKDKHRDR DSRHQQDSDL SVAHSDADLH RHKKKKKKKK
1260 1270 1280 1290 1300
RHSRKSEDFG RDSEPRLPKA ASCETVDHFR KAEGAFPLAD GLPLEGAAPF
1310 1320 1330
CEKTKHFRME SREVRCRLSQ CDQGKGARWE SGS
Length:1,333
Mass (Da):146,748
Last modified:November 2, 2010 - v1
Checksum:i8E638010675EA919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03050082 Genomic DNA. No translation available.
UniGeneiBt.42050.

Genome annotation databases

EnsembliENSBTAT00000000967; ENSBTAP00000000967; ENSBTAG00000000725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03050082 Genomic DNA. No translation available.
UniGenei Bt.42050.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000000967 ; ENSBTAP00000000967 ; ENSBTAG00000000725 .

Phylogenomic databases

GeneTreei ENSGT00760000119279.
InParanoidi E1B9W9.
OMAi GKLMPAP.
OrthoDBi EOG72VH5K.
TreeFami TF315281.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP42_BOVIN
AccessioniPrimary (citable) accession number: E1B9W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3