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E1B9W9

- UBP42_BOVIN

UniProt

E1B9W9 - UBP42_BOVIN

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Protein
Ubiquitin carboxyl-terminal hydrolase 42
Gene
USP42
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei120 – 1201Nucleophile By similarity
Active sitei371 – 3711Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. protein deubiquitination Source: UniProtKB
  3. spermatogenesis Source: UniProtKB-KW
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:USP42
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333Ubiquitin carboxyl-terminal hydrolase 42
PRO_0000404198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei863 – 8631Phosphoserine By similarity
Modified residuei1235 – 12351Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 412302USP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 674Poly-Ser
Compositional biasi952 – 1126175Arg-rich
Add
BLAST
Compositional biasi1185 – 125571Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

GeneTreeiENSGT00750000117288.
OMAiGKLMPAP.
OrthoDBiEOG72VH5K.
TreeFamiTF315281.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1B9W9-1 [UniParc]FASTAAdd to Basket

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MTIVDKASES SDPSTYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH     50
TLSLGPVPGA VVYSSSSVPE KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC 100
LKWQQTHRVG AGLQNLGNTC FANAALQCLT YTPPLANYML SHEHSKTCHA 150
EGFCMMCTMQ AHITQALSNP GDVIKPMFVI NEMRRIARHF RFGNQEDAHE 200
FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS RVKCLNCKGV 250
SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA 300
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE 350
PIIYVLYAVL VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL 400
SQQAYVLFYI RSHDVKNGGE LTHSAHSPGQ SSPRPVISQR VVNSKQAASG 450
FIGPQLPSHM MKNPPHLNGT GPLKETPSSP MSGPSGNSSV SRTGPVSASP 500
SVQNWSVNRP SVIPEHPKKQ KITISIHNKL PVRQGQSQSN LHSNSLEHPN 550
KPAPSSTITT SSAIQSTSSA PTPPASSKVP KQMAPREACS RPMMNGRPRL 600
SAGVLVPYGA ESSEESDEEA KGLGQENGRG LTESACSPAL DAEDGDASPH 650
ELQEPVALNG ATGLDSDPTE NGLPSDGAPC PGQPALHSEH PFPKANGLPG 700
KLMPAPLPPL PEDKILETFK LGSKAKGSAE ETRTPGSEER PLEHPEAELE 750
AGRSPPGDAR DNLESVSNLS SKFKKASPPS DPSIKPTKEE VSERVSAEPE 800
EAVPSASTFC NPDKDALGDD QLLAPCDPGN LTDDQSKPSP DVGGTLPERP 850
QDPVAAEAAG RLSPGPSVPS EGDHEPEPLG HSGRDRGSDA EGPSKSMGVS 900
TDEAPSAQLD TITENRPEGP PERSSSERGE DSKAGQKAPE PCLVQEKVSS 950
LRKVDRGHYR SRRDRSSSGE HARESRSRTE VQHRRKRPHR EHERPRPERP 1000
RPEPCALAPQ PPCPSSLARS GHHHSRSRGA PDQEWGRYHH AEGDHAWTRE 1050
KYYPDRLRWE RCRYHHDRSP LYPSREPRDW RPFHAEREYE RAGPYGGRPY 1100
KDHYRGRKGY ELVAKERDRH RFSSPRAGMA HAPPPHPAAK YTHDRLSFGA 1150
EDGSCDLAAR FHEHDNIKSR KRRYDSLENE SHVEKKAWRS LQKDPVEEPK 1200
VKKHKKSKKK KKSKDKHRDR DSRHQQDSDL SVAHSDADLH RHKKKKKKKK 1250
RHSRKSEDFG RDSEPRLPKA ASCETVDHFR KAEGAFPLAD GLPLEGAAPF 1300
CEKTKHFRME SREVRCRLSQ CDQGKGARWE SGS 1333
Length:1,333
Mass (Da):146,748
Last modified:November 2, 2010 - v1
Checksum:i8E638010675EA919
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFC03050082 Genomic DNA. No translation available.
UniGeneiBt.42050.

Genome annotation databases

EnsembliENSBTAT00000000967; ENSBTAP00000000967; ENSBTAG00000000725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFC03050082 Genomic DNA. No translation available.
UniGenei Bt.42050.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000000967 ; ENSBTAP00000000967 ; ENSBTAG00000000725 .

Phylogenomic databases

GeneTreei ENSGT00750000117288.
OMAi GKLMPAP.
OrthoDBi EOG72VH5K.
TreeFami TF315281.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBP42_BOVIN
AccessioniPrimary (citable) accession number: E1B9W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi