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E1B9W9

- UBP42_BOVIN

UniProt

E1B9W9 - UBP42_BOVIN

Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

USP42

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme which may play an important role during spermatogenesis.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei120 – 1201NucleophilePROSITE-ProRule annotation
    Active sitei371 – 3711Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: Ensembl

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. protein deubiquitination Source: UniProtKB
    3. spermatogenesis Source: UniProtKB-KW
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 42
    Ubiquitin thioesterase 42
    Ubiquitin-specific-processing protease 42
    Gene namesi
    Name:USP42
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13331333Ubiquitin carboxyl-terminal hydrolase 42PRO_0000404198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei863 – 8631PhosphoserineBy similarity
    Modified residuei1235 – 12351PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini111 – 412302USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 674Poly-Ser
    Compositional biasi952 – 1126175Arg-richAdd
    BLAST
    Compositional biasi1185 – 125571Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    GeneTreeiENSGT00750000117288.
    OMAiGKLMPAP.
    OrthoDBiEOG72VH5K.
    TreeFamiTF315281.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1B9W9-1 [UniParc]FASTAAdd to Basket

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    MTIVDKASES SDPSTYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH     50
    TLSLGPVPGA VVYSSSSVPE KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC 100
    LKWQQTHRVG AGLQNLGNTC FANAALQCLT YTPPLANYML SHEHSKTCHA 150
    EGFCMMCTMQ AHITQALSNP GDVIKPMFVI NEMRRIARHF RFGNQEDAHE 200
    FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS RVKCLNCKGV 250
    SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA 300
    SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE 350
    PIIYVLYAVL VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL 400
    SQQAYVLFYI RSHDVKNGGE LTHSAHSPGQ SSPRPVISQR VVNSKQAASG 450
    FIGPQLPSHM MKNPPHLNGT GPLKETPSSP MSGPSGNSSV SRTGPVSASP 500
    SVQNWSVNRP SVIPEHPKKQ KITISIHNKL PVRQGQSQSN LHSNSLEHPN 550
    KPAPSSTITT SSAIQSTSSA PTPPASSKVP KQMAPREACS RPMMNGRPRL 600
    SAGVLVPYGA ESSEESDEEA KGLGQENGRG LTESACSPAL DAEDGDASPH 650
    ELQEPVALNG ATGLDSDPTE NGLPSDGAPC PGQPALHSEH PFPKANGLPG 700
    KLMPAPLPPL PEDKILETFK LGSKAKGSAE ETRTPGSEER PLEHPEAELE 750
    AGRSPPGDAR DNLESVSNLS SKFKKASPPS DPSIKPTKEE VSERVSAEPE 800
    EAVPSASTFC NPDKDALGDD QLLAPCDPGN LTDDQSKPSP DVGGTLPERP 850
    QDPVAAEAAG RLSPGPSVPS EGDHEPEPLG HSGRDRGSDA EGPSKSMGVS 900
    TDEAPSAQLD TITENRPEGP PERSSSERGE DSKAGQKAPE PCLVQEKVSS 950
    LRKVDRGHYR SRRDRSSSGE HARESRSRTE VQHRRKRPHR EHERPRPERP 1000
    RPEPCALAPQ PPCPSSLARS GHHHSRSRGA PDQEWGRYHH AEGDHAWTRE 1050
    KYYPDRLRWE RCRYHHDRSP LYPSREPRDW RPFHAEREYE RAGPYGGRPY 1100
    KDHYRGRKGY ELVAKERDRH RFSSPRAGMA HAPPPHPAAK YTHDRLSFGA 1150
    EDGSCDLAAR FHEHDNIKSR KRRYDSLENE SHVEKKAWRS LQKDPVEEPK 1200
    VKKHKKSKKK KKSKDKHRDR DSRHQQDSDL SVAHSDADLH RHKKKKKKKK 1250
    RHSRKSEDFG RDSEPRLPKA ASCETVDHFR KAEGAFPLAD GLPLEGAAPF 1300
    CEKTKHFRME SREVRCRLSQ CDQGKGARWE SGS 1333
    Length:1,333
    Mass (Da):146,748
    Last modified:November 2, 2010 - v1
    Checksum:i8E638010675EA919
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03050082 Genomic DNA. No translation available.
    UniGeneiBt.42050.

    Genome annotation databases

    EnsembliENSBTAT00000000967; ENSBTAP00000000967; ENSBTAG00000000725.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03050082 Genomic DNA. No translation available.
    UniGenei Bt.42050.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000000967 ; ENSBTAP00000000967 ; ENSBTAG00000000725 .

    Phylogenomic databases

    GeneTreei ENSGT00750000117288.
    OMAi GKLMPAP.
    OrthoDBi EOG72VH5K.
    TreeFami TF315281.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
      The bovine genome sequencing and analysis consortium
      Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUBP42_BOVIN
    AccessioniPrimary (citable) accession number: E1B9W9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3