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Protein

Mitogen-activated protein kinase

Gene

MAPK3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. cartilage development Source: Ensembl
  3. cellular response to mechanical stimulus Source: Ensembl
  4. DNA damage induced protein phosphorylation Source: Ensembl
  5. interleukin-1-mediated signaling pathway Source: Ensembl
  6. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  7. negative regulation of apolipoprotein binding Source: Ensembl
  8. organ morphogenesis Source: Ensembl
  9. peptidyl-tyrosine autophosphorylation Source: Ensembl
  10. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  11. positive regulation of histone acetylation Source: Ensembl
  12. positive regulation of histone phosphorylation Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  15. response to epidermal growth factor Source: Ensembl
  16. response to exogenous dsRNA Source: Ensembl
  17. sensory perception of pain Source: Ensembl
  18. transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_271820. Thrombin signalling through proteinase activated receptors (PARs).
REACT_273697. Activation of the AP-1 family of transcription factors.
REACT_277246. Oncogene Induced Senescence.
REACT_278715. ISG15 antiviral mechanism.
REACT_279766. Golgi Cisternae Pericentriolar Stack Reorganization.
REACT_281157. ERK/MAPK targets.
REACT_283854. Oxidative Stress Induced Senescence.
REACT_285394. ERKs are inactivated.
REACT_289359. Signaling by FGFR.
REACT_289918. ERK1 activation.
REACT_291362. Negative regulation of FGFR signaling.
REACT_292392. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_304147. Signal transduction by L1.
REACT_308874. RNA Polymerase I Promoter Opening.
REACT_318368. Growth hormone receptor signaling.
REACT_319858. Regulation of actin dynamics for phagocytic cup formation.
REACT_331904. FCERI mediated MAPK activation.
REACT_338158. Regulation of HSF1-mediated heat shock response.
REACT_350372. Advanced glycosylation endproduct receptor signaling.
REACT_351362. Senescence-Associated Secretory Phenotype (SASP).
REACT_353424. Signal attenuation.
REACT_354810. NCAM signaling for neurite out-growth.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Name:MAPK3Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. microtubule cytoskeleton Source: Ensembl
  4. nucleus Source: Ensembl
  5. pseudopodium Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliE1B8P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074298.
InParanoidiE1B8P9.
KOiK04371.
OMAiQETAPFQ.
OrthoDBiEOG7M3J0K.
TreeFamiTF105097.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1B8P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAQGG GEIVKGQPFD VGPRYTQLQY IGEGAYGMVS SAYDHVRKTR
60 70 80 90 100
VAIKKISPFE HQTYCQRTLR EIQILLRFRH ENVIGIRDIL RAPTLEAMRD
110 120 130 140 150
VYIVQDLMET DLYKLLKSQQ LSNDHVCYFL YQILRGLKYI HSANVLHRDL
160 170 180 190 200
KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML
210 220 230 240 250
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE
260 270 280 290 300
DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDPKALDLL DRMLTFNPNK
310 320 330 340 350
RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE
360
TARFQPGVLE AS
Length:362
Mass (Da):41,497
Last modified:November 1, 2010 - v1
Checksum:i70F37FE605D1559B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02057893 Genomic DNA. No translation available.
DAAA02057894 Genomic DNA. No translation available.
RefSeqiNP_001103488.1. NM_001110018.1.
UniGeneiBt.5687.

Genome annotation databases

EnsembliENSBTAT00000021507; ENSBTAP00000021507; ENSBTAG00000016156.
GeneIDi531391.
KEGGibta:531391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02057893 Genomic DNA. No translation available.
DAAA02057894 Genomic DNA. No translation available.
RefSeqiNP_001103488.1. NM_001110018.1.
UniGeneiBt.5687.

3D structure databases

ProteinModelPortaliE1B8P9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021507; ENSBTAP00000021507; ENSBTAG00000016156.
GeneIDi531391.
KEGGibta:531391.

Organism-specific databases

CTDi5595.

Phylogenomic databases

GeneTreeiENSGT00550000074298.
InParanoidiE1B8P9.
KOiK04371.
OMAiQETAPFQ.
OrthoDBiEOG7M3J0K.
TreeFamiTF105097.

Enzyme and pathway databases

ReactomeiREACT_271820. Thrombin signalling through proteinase activated receptors (PARs).
REACT_273697. Activation of the AP-1 family of transcription factors.
REACT_277246. Oncogene Induced Senescence.
REACT_278715. ISG15 antiviral mechanism.
REACT_279766. Golgi Cisternae Pericentriolar Stack Reorganization.
REACT_281157. ERK/MAPK targets.
REACT_283854. Oxidative Stress Induced Senescence.
REACT_285394. ERKs are inactivated.
REACT_289359. Signaling by FGFR.
REACT_289918. ERK1 activation.
REACT_291362. Negative regulation of FGFR signaling.
REACT_292392. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_304147. Signal transduction by L1.
REACT_308874. RNA Polymerase I Promoter Opening.
REACT_318368. Growth hormone receptor signaling.
REACT_319858. Regulation of actin dynamics for phagocytic cup formation.
REACT_331904. FCERI mediated MAPK activation.
REACT_338158. Regulation of HSF1-mediated heat shock response.
REACT_350372. Advanced glycosylation endproduct receptor signaling.
REACT_351362. Senescence-Associated Secretory Phenotype (SASP).
REACT_353424. Signal attenuation.
REACT_354810. NCAM signaling for neurite out-growth.

Miscellaneous databases

NextBioi20875449.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiE1B8P9_BOVIN
AccessioniPrimary (citable) accession number: E1B8P9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 2010
Last sequence update: November 1, 2010
Last modified: March 31, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.