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Protein

Mitogen-activated protein kinase

Gene

MAPK3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-110056 MAPK3 (ERK1) activation
R-BTA-112409 RAF-independent MAPK1/3 activation
R-BTA-1169408 ISG15 antiviral mechanism
R-BTA-1295596 Spry regulation of FGF signaling
R-BTA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-BTA-198753 ERK/MAPK targets
R-BTA-202670 ERKs are inactivated
R-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-BTA-2559580 Oxidative Stress Induced Senescence
R-BTA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-BTA-2559585 Oncogene Induced Senescence
R-BTA-2871796 FCERI mediated MAPK activation
R-BTA-3371453 Regulation of HSF1-mediated heat shock response
R-BTA-375165 NCAM signaling for neurite out-growth
R-BTA-445144 Signal transduction by L1
R-BTA-450341 Activation of the AP-1 family of transcription factors
R-BTA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-5654726 Negative regulation of FGFR1 signaling
R-BTA-5654727 Negative regulation of FGFR2 signaling
R-BTA-5654732 Negative regulation of FGFR3 signaling
R-BTA-5654733 Negative regulation of FGFR4 signaling
R-BTA-5663213 RHO GTPases Activate WASPs and WAVEs
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-5674499 Negative feedback regulation of MAPK pathway
R-BTA-5675221 Negative regulation of MAPK pathway
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-73728 RNA Polymerase I Promoter Opening
R-BTA-74749 Signal attenuation
R-BTA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-BTA-8939211 ESR-mediated signaling
R-BTA-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Name:MAPK3Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:31219 MAPK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE1B8P9

Expressioni

Gene expression databases

BgeeiENSBTAG00000016156

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021507

Structurei

3D structure databases

ProteinModelPortaliE1B8P9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 313Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00910000144035
InParanoidiE1B8P9
KOiK04371
OMAiAYGMVSS
OrthoDBiEOG091G08QL
TreeFamiTF105097

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008349 MAPK_ERK1/2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01770 ERK1ERK2MAPK
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

E1B8P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAQGG GEIVKGQPFD VGPRYTQLQY IGEGAYGMVS SAYDHVRKTR
60 70 80 90 100
VAIKKISPFE HQTYCQRTLR EIQILLRFRH ENVIGIRDIL RAPTLEAMRD
110 120 130 140 150
VYIVQDLMET DLYKLLKSQQ LSNDHVCYFL YQILRGLKYI HSANVLHRDL
160 170 180 190 200
KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML
210 220 230 240 250
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE
260 270 280 290 300
DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDPKALDLL DRMLTFNPNK
310 320 330 340 350
RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE
360
TARFQPGVLE AS
Length:362
Mass (Da):41,497
Last modified:November 2, 2010 - v1
Checksum:i70F37FE605D1559B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02057893 Genomic DNA No translation available.
DAAA02057894 Genomic DNA No translation available.
RefSeqiNP_001103488.1, NM_001110018.1
UniGeneiBt.5687

Genome annotation databases

EnsembliENSBTAT00000021507; ENSBTAP00000021507; ENSBTAG00000016156
GeneIDi531391
KEGGibta:531391

Similar proteinsi

Entry informationi

Entry nameiE1B8P9_BOVIN
AccessioniPrimary (citable) accession number: E1B8P9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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