Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

E1B8P9

- E1B8P9_BOVIN

UniProt

E1B8P9 - E1B8P9_BOVIN

Protein

Mitogen-activated protein kinase

Gene

MAPK3

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: InterPro

    GO - Biological processi

    1. BMP signaling pathway Source: Ensembl
    2. cartilage development Source: Ensembl
    3. cellular response to mechanical stimulus Source: Ensembl
    4. DNA damage induced protein phosphorylation Source: Ensembl
    5. interleukin-1-mediated signaling pathway Source: Ensembl
    6. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    7. negative regulation of apolipoprotein binding Source: Ensembl
    8. organ morphogenesis Source: Ensembl
    9. peptidyl-tyrosine autophosphorylation Source: Ensembl
    10. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    11. positive regulation of histone acetylation Source: Ensembl
    12. positive regulation of histone phosphorylation Source: Ensembl
    13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    14. regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    15. response to epidermal growth factor Source: Ensembl
    16. response to exogenous dsRNA Source: Ensembl
    17. sensory perception of pain Source: Ensembl
    18. transcription, DNA-templated Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_202074. FCERI mediated MAPK activation.
    REACT_202837. Signaling by FGFR.
    REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
    REACT_204725. Advanced glycosylation endproduct receptor signaling.
    REACT_205036. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_207562. Negative regulation of FGFR signaling.
    REACT_209393. Growth hormone receptor signaling.
    REACT_211475. Regulation of actin dynamics for phagocytic cup formation.
    REACT_211838. RNA Polymerase I Promoter Opening.
    REACT_215264. ISG15 antiviral mechanism.
    REACT_215912. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_216684. Signal transduction by L1.
    REACT_217282. NCAM signaling for neurite out-growth.
    REACT_217767. Oncogene Induced Senescence.
    REACT_218726. Regulation of HSF1-mediated heat shock response.
    REACT_220172. Golgi Cisternae Pericentriolar Stack Reorganization.
    REACT_220398. ERKs are inactivated.
    REACT_221197. Activation of the AP-1 family of transcription factors.
    REACT_225657. Oxidative Stress Induced Senescence.
    REACT_226850. ERK/MAPK targets.
    REACT_227498. ERK1 activation.
    REACT_227700. Signal attenuation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinaseUniRule annotation (EC:2.7.11.24UniRule annotation)
    Gene namesi
    Name:MAPK3Imported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. microtubule cytoskeleton Source: Ensembl
    3. nucleus Source: Ensembl
    4. pseudopodium Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliE1B8P9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
    Contains 1 protein kinase domain.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074298.
    KOiK04371.
    OMAiAEMLSNK.
    OrthoDBiEOG7M3J0K.
    TreeFamiTF105097.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008349. MAPK_ERK1/2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01770. ERK1ERK2MAPK.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E1B8P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAAAQGG GEIVKGQPFD VGPRYTQLQY IGEGAYGMVS SAYDHVRKTR    50
    VAIKKISPFE HQTYCQRTLR EIQILLRFRH ENVIGIRDIL RAPTLEAMRD 100
    VYIVQDLMET DLYKLLKSQQ LSNDHVCYFL YQILRGLKYI HSANVLHRDL 150
    KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML 200
    NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE 250
    DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDPKALDLL DRMLTFNPNK 300
    RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE 350
    TARFQPGVLE AS 362
    Length:362
    Mass (Da):41,497
    Last modified:November 2, 2010 - v1
    Checksum:i70F37FE605D1559B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02057893 Genomic DNA. No translation available.
    DAAA02057894 Genomic DNA. No translation available.
    RefSeqiNP_001103488.1. NM_001110018.1.
    UniGeneiBt.5687.

    Genome annotation databases

    EnsembliENSBTAT00000021507; ENSBTAP00000021507; ENSBTAG00000016156.
    GeneIDi531391.
    KEGGibta:531391.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02057893 Genomic DNA. No translation available.
    DAAA02057894 Genomic DNA. No translation available.
    RefSeqi NP_001103488.1. NM_001110018.1.
    UniGenei Bt.5687.

    3D structure databases

    ProteinModelPortali E1B8P9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021507 ; ENSBTAP00000021507 ; ENSBTAG00000016156 .
    GeneIDi 531391.
    KEGGi bta:531391.

    Organism-specific databases

    CTDi 5595.

    Phylogenomic databases

    GeneTreei ENSGT00550000074298.
    KOi K04371.
    OMAi AEMLSNK.
    OrthoDBi EOG7M3J0K.
    TreeFami TF105097.

    Enzyme and pathway databases

    Reactomei REACT_202074. FCERI mediated MAPK activation.
    REACT_202837. Signaling by FGFR.
    REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
    REACT_204725. Advanced glycosylation endproduct receptor signaling.
    REACT_205036. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_207562. Negative regulation of FGFR signaling.
    REACT_209393. Growth hormone receptor signaling.
    REACT_211475. Regulation of actin dynamics for phagocytic cup formation.
    REACT_211838. RNA Polymerase I Promoter Opening.
    REACT_215264. ISG15 antiviral mechanism.
    REACT_215912. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_216684. Signal transduction by L1.
    REACT_217282. NCAM signaling for neurite out-growth.
    REACT_217767. Oncogene Induced Senescence.
    REACT_218726. Regulation of HSF1-mediated heat shock response.
    REACT_220172. Golgi Cisternae Pericentriolar Stack Reorganization.
    REACT_220398. ERKs are inactivated.
    REACT_221197. Activation of the AP-1 family of transcription factors.
    REACT_225657. Oxidative Stress Induced Senescence.
    REACT_226850. ERK/MAPK targets.
    REACT_227498. ERK1 activation.
    REACT_227700. Signal attenuation.

    Miscellaneous databases

    NextBioi 20875449.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008349. MAPK_ERK1/2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01770. ERK1ERK2MAPK.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiE1B8P9_BOVIN
    AccessioniPrimary (citable) accession number: E1B8P9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3