Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitogen-activated protein kinase

Gene

MAPK3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-110056. MAPK3 (ERK1) activation.
R-BTA-112409. RAF-independent MAPK1/3 activation.
R-BTA-1169408. ISG15 antiviral mechanism.
R-BTA-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-BTA-198753. ERK/MAPK targets.
R-BTA-202670. ERKs are inactivated.
R-BTA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-BTA-2559580. Oxidative Stress Induced Senescence.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-2559585. Oncogene Induced Senescence.
R-BTA-2871796. FCERI mediated MAPK activation.
R-BTA-3371453. Regulation of HSF1-mediated heat shock response.
R-BTA-375165. NCAM signaling for neurite out-growth.
R-BTA-445144. Signal transduction by L1.
R-BTA-450341. Activation of the AP-1 family of transcription factors.
R-BTA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-BTA-5654726. Negative regulation of FGFR1 signaling.
R-BTA-5654727. Negative regulation of FGFR2 signaling.
R-BTA-5654732. Negative regulation of FGFR3 signaling.
R-BTA-5654733. Negative regulation of FGFR4 signaling.
R-BTA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-BTA-5673001. RAF/MAP kinase cascade.
R-BTA-5674135. MAP2K and MAPK activation.
R-BTA-5674499. Negative feedback regulation of MAPK pathway.
R-BTA-5675221. Negative regulation of MAPK pathway.
R-BTA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-BTA-73728. RNA Polymerase I Promoter Opening.
R-BTA-74749. Signal attenuation.
R-BTA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.
R-BTA-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Name:MAPK3Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiE1B8P9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016156.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021507.

Structurei

3D structure databases

ProteinModelPortaliE1B8P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 313289Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074298.
InParanoidiE1B8P9.
KOiK04371.
OMAiRAPCADS.
OrthoDBiEOG091G08QL.
TreeFamiTF105097.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1B8P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAQGG GEIVKGQPFD VGPRYTQLQY IGEGAYGMVS SAYDHVRKTR
60 70 80 90 100
VAIKKISPFE HQTYCQRTLR EIQILLRFRH ENVIGIRDIL RAPTLEAMRD
110 120 130 140 150
VYIVQDLMET DLYKLLKSQQ LSNDHVCYFL YQILRGLKYI HSANVLHRDL
160 170 180 190 200
KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML
210 220 230 240 250
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE
260 270 280 290 300
DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDPKALDLL DRMLTFNPNK
310 320 330 340 350
RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE
360
TARFQPGVLE AS
Length:362
Mass (Da):41,497
Last modified:November 2, 2010 - v1
Checksum:i70F37FE605D1559B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02057893 Genomic DNA. No translation available.
DAAA02057894 Genomic DNA. No translation available.
RefSeqiNP_001103488.1. NM_001110018.1.
UniGeneiBt.5687.

Genome annotation databases

EnsembliENSBTAT00000021507; ENSBTAP00000021507; ENSBTAG00000016156.
GeneIDi531391.
KEGGibta:531391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02057893 Genomic DNA. No translation available.
DAAA02057894 Genomic DNA. No translation available.
RefSeqiNP_001103488.1. NM_001110018.1.
UniGeneiBt.5687.

3D structure databases

ProteinModelPortaliE1B8P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021507.

Proteomic databases

PaxDbiE1B8P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021507; ENSBTAP00000021507; ENSBTAG00000016156.
GeneIDi531391.
KEGGibta:531391.

Organism-specific databases

CTDi5595.

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074298.
InParanoidiE1B8P9.
KOiK04371.
OMAiRAPCADS.
OrthoDBiEOG091G08QL.
TreeFamiTF105097.

Enzyme and pathway databases

ReactomeiR-BTA-110056. MAPK3 (ERK1) activation.
R-BTA-112409. RAF-independent MAPK1/3 activation.
R-BTA-1169408. ISG15 antiviral mechanism.
R-BTA-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-BTA-198753. ERK/MAPK targets.
R-BTA-202670. ERKs are inactivated.
R-BTA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-BTA-2559580. Oxidative Stress Induced Senescence.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-2559585. Oncogene Induced Senescence.
R-BTA-2871796. FCERI mediated MAPK activation.
R-BTA-3371453. Regulation of HSF1-mediated heat shock response.
R-BTA-375165. NCAM signaling for neurite out-growth.
R-BTA-445144. Signal transduction by L1.
R-BTA-450341. Activation of the AP-1 family of transcription factors.
R-BTA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-BTA-5654726. Negative regulation of FGFR1 signaling.
R-BTA-5654727. Negative regulation of FGFR2 signaling.
R-BTA-5654732. Negative regulation of FGFR3 signaling.
R-BTA-5654733. Negative regulation of FGFR4 signaling.
R-BTA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-BTA-5673001. RAF/MAP kinase cascade.
R-BTA-5674135. MAP2K and MAPK activation.
R-BTA-5674499. Negative feedback regulation of MAPK pathway.
R-BTA-5675221. Negative regulation of MAPK pathway.
R-BTA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-BTA-73728. RNA Polymerase I Promoter Opening.
R-BTA-74749. Signal attenuation.
R-BTA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.
R-BTA-982772. Growth hormone receptor signaling.

Gene expression databases

BgeeiENSBTAG00000016156.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE1B8P9_BOVIN
AccessioniPrimary (citable) accession number: E1B8P9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.