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E1B8P9

- E1B8P9_BOVIN

UniProt

E1B8P9 - E1B8P9_BOVIN

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Protein

Mitogen-activated protein kinase

Gene

MAPK3

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Magnesium.UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. cartilage development Source: Ensembl
  3. cellular response to mechanical stimulus Source: Ensembl
  4. DNA damage induced protein phosphorylation Source: Ensembl
  5. interleukin-1-mediated signaling pathway Source: Ensembl
  6. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  7. negative regulation of apolipoprotein binding Source: Ensembl
  8. organ morphogenesis Source: Ensembl
  9. peptidyl-tyrosine autophosphorylation Source: Ensembl
  10. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  11. positive regulation of histone acetylation Source: Ensembl
  12. positive regulation of histone phosphorylation Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  15. response to epidermal growth factor Source: Ensembl
  16. response to exogenous dsRNA Source: Ensembl
  17. sensory perception of pain Source: Ensembl
  18. transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_202074. FCERI mediated MAPK activation.
REACT_202837. Signaling by FGFR.
REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
REACT_204725. Advanced glycosylation endproduct receptor signaling.
REACT_205036. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_207562. Negative regulation of FGFR signaling.
REACT_209393. Growth hormone receptor signaling.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.
REACT_211838. RNA Polymerase I Promoter Opening.
REACT_215264. ISG15 antiviral mechanism.
REACT_215912. Thrombin signalling through proteinase activated receptors (PARs).
REACT_216684. Signal transduction by L1.
REACT_217282. NCAM signaling for neurite out-growth.
REACT_217767. Oncogene Induced Senescence.
REACT_218726. Regulation of HSF1-mediated heat shock response.
REACT_220172. Golgi Cisternae Pericentriolar Stack Reorganization.
REACT_220398. ERKs are inactivated.
REACT_221197. Activation of the AP-1 family of transcription factors.
REACT_225657. Oxidative Stress Induced Senescence.
REACT_226850. ERK/MAPK targets.
REACT_227498. ERK1 activation.
REACT_227700. Signal attenuation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotation (EC:2.7.11.24UniRule annotation)
Gene namesi
Name:MAPK3Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. microtubule cytoskeleton Source: Ensembl
  4. nucleus Source: Ensembl
  5. pseudopodium Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliE1B8P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074298.
InParanoidiE1B8P9.
KOiK04371.
OMAiAEMLSNK.
OrthoDBiEOG7M3J0K.
TreeFamiTF105097.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E1B8P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAAAQGG GEIVKGQPFD VGPRYTQLQY IGEGAYGMVS SAYDHVRKTR
60 70 80 90 100
VAIKKISPFE HQTYCQRTLR EIQILLRFRH ENVIGIRDIL RAPTLEAMRD
110 120 130 140 150
VYIVQDLMET DLYKLLKSQQ LSNDHVCYFL YQILRGLKYI HSANVLHRDL
160 170 180 190 200
KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML
210 220 230 240 250
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE
260 270 280 290 300
DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDPKALDLL DRMLTFNPNK
310 320 330 340 350
RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE
360
TARFQPGVLE AS
Length:362
Mass (Da):41,497
Last modified:November 2, 2010 - v1
Checksum:i70F37FE605D1559B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02057893 Genomic DNA. No translation available.
DAAA02057894 Genomic DNA. No translation available.
RefSeqiNP_001103488.1. NM_001110018.1.
UniGeneiBt.5687.

Genome annotation databases

EnsembliENSBTAT00000021507; ENSBTAP00000021507; ENSBTAG00000016156.
GeneIDi531391.
KEGGibta:531391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02057893 Genomic DNA. No translation available.
DAAA02057894 Genomic DNA. No translation available.
RefSeqi NP_001103488.1. NM_001110018.1.
UniGenei Bt.5687.

3D structure databases

ProteinModelPortali E1B8P9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021507 ; ENSBTAP00000021507 ; ENSBTAG00000016156 .
GeneIDi 531391.
KEGGi bta:531391.

Organism-specific databases

CTDi 5595.

Phylogenomic databases

GeneTreei ENSGT00550000074298.
InParanoidi E1B8P9.
KOi K04371.
OMAi AEMLSNK.
OrthoDBi EOG7M3J0K.
TreeFami TF105097.

Enzyme and pathway databases

Reactomei REACT_202074. FCERI mediated MAPK activation.
REACT_202837. Signaling by FGFR.
REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
REACT_204725. Advanced glycosylation endproduct receptor signaling.
REACT_205036. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_207562. Negative regulation of FGFR signaling.
REACT_209393. Growth hormone receptor signaling.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.
REACT_211838. RNA Polymerase I Promoter Opening.
REACT_215264. ISG15 antiviral mechanism.
REACT_215912. Thrombin signalling through proteinase activated receptors (PARs).
REACT_216684. Signal transduction by L1.
REACT_217282. NCAM signaling for neurite out-growth.
REACT_217767. Oncogene Induced Senescence.
REACT_218726. Regulation of HSF1-mediated heat shock response.
REACT_220172. Golgi Cisternae Pericentriolar Stack Reorganization.
REACT_220398. ERKs are inactivated.
REACT_221197. Activation of the AP-1 family of transcription factors.
REACT_225657. Oxidative Stress Induced Senescence.
REACT_226850. ERK/MAPK targets.
REACT_227498. ERK1 activation.
REACT_227700. Signal attenuation.

Miscellaneous databases

NextBioi 20875449.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01770. ERK1ERK2MAPK.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiE1B8P9_BOVIN
AccessioniPrimary (citable) accession number: E1B8P9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3