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Protein
Submitted name:

DNA ligase, putative

Gene

Phum_PHUM592850

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
DNA ligase, putativeImported (EC:6.5.1.1Imported)
Gene namesi
ORF Names:Phum_PHUM592850Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046: Partially assembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliE0W2H3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiE0W2H3.
KOiK10777.
OMAiLQEENQY.
OrthoDBiEOG7BKCT2.
PhylomeDBiE0W2H3.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0W2H3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLAKKISFG NFCQLCSKIK SADHEKKIII LRNYISNWKK KAKDIESDGL
60 70 80 90 100
NLDDSFFPIF RLLIPHLDRE RGAYGIKERT LAKIYISILS LPKDGEDALK
110 120 130 140 150
LLNCKNPKTS YFNNCDFASI AFCILRNRCA EGGQLSVEEV NKHLDKISTS
160 170 180 190 200
HAANEPRNVD AELISLLKST NAEEQKWLIR ILLKDVKLGL SENVIFKCYH
210 220 230 240 250
PDARELYDSS NSLRKICDLL NDPEIRLNEI QIQLFTPFKP MLSEECDIQK
260 270 280 290 300
IDYYLKRSCH FFIETKLDGE RFQLHFEEGN FKYFSRNGYD FTTNFGSSKR
310 320 330 340 350
EGNLSPRIFK RIPPHVKSFV LDGEMMSWDR ITRSFSSKGK NLDVKNLKEG
360 370 380 390 400
NHYQSCFCVF DILLYNGEVL TNKPLIARLE ILEKIIEPEE GTIIILNRKQ
410 420 430 440 450
ISSNSEVIDS LNEAIDNREE GIVMKESMSV YKPNVRKNGG WYKIKPEYTD
460 470 480 490 500
GLAETLDLLI IGGYYGRGHL KGSVNHFLLG AAVNVSDDNI LFYSTGRVGS
510 520 530 540 550
GYSIKDLEDL SLKLKPYWKE AKNDRMPLSV KWGKEKPDVW IKPDKSYILE
560 570 580 590 600
IKASEIVSSA IFKSGYALRF PRVEKIRYDK TWKECLTLHN LEEIAKIASG
610 620 630 640 650
KLTASHFSQS NIPSFLPKKK AKTSIWNINS ENFDFSGIKC ISKLLQGKEI
660 670 680 690 700
CVFSGFKNIK KLDLEKKVVE FGGKLVKNPG KNTFCILAES DNHTRIKNII
710 720 730 740 750
KCGSYDILYS SCFFSFLKIE NVKMPKLKPE HFLAMSKGTK EEFSKSYDKY
760 770 780 790 800
GDHFTKKSTF DAIKHSLNAA SQEGKNIVLT SDEIYEMDVN LFGKTSPYSI
810 820 830 840 850
FRNHVGYFDQ FKIVSDSSSK FSSDLDLFKI DFRFYGGKCS DAIDDSTVTH
860 870 880 890
VITLSSDSSR INEINNENHK RKRKFHVVNE KWIESCIKEN A
Length:891
Mass (Da):102,161
Last modified:November 2, 2010 - v1
Checksum:iE252DFE0E852D929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235878 Genomic DNA. Translation: EEB19829.1.
RefSeqiXP_002432567.1. XM_002432522.1.

Genome annotation databases

EnsemblMetazoaiPHUM592850-RA; PHUM592850-PA; PHUM592850.
GeneIDi8232803.
KEGGiphu:Phum_PHUM592850.
VectorBaseiPHUM592850. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235878 Genomic DNA. Translation: EEB19829.1.
RefSeqiXP_002432567.1. XM_002432522.1.

3D structure databases

ProteinModelPortaliE0W2H3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM592850-RA; PHUM592850-PA; PHUM592850.
GeneIDi8232803.
KEGGiphu:Phum_PHUM592850.
VectorBaseiPHUM592850. Pediculus humanus.

Organism-specific databases

CTDi8232803.

Phylogenomic databases

InParanoidiE0W2H3.
KOiK10777.
OMAiLQEENQY.
OrthoDBiEOG7BKCT2.
PhylomeDBiE0W2H3.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0W2H3_PEDHC
AccessioniPrimary (citable) accession number: E0W2H3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.