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Protein

Histone deacetylase

Gene

8235461

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1050 – 1111UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorSAAS annotation, HydrolaseSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseSAAS annotation (EC:3.5.1.98SAAS annotation)
Gene namesi
Name:8235461Imported
ORF Names:Phum_PHUM538580Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
Proteomesi
  • UP000009046 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei977 – 1007HelicalSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane, NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi121225.PHUM538580-PA.

Structurei

3D structure databases

ProteinModelPortaliE0VZV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1050 – 1111UBP-typeInterPro annotationAdd BLAST62

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1050 – 1111UBP-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoidiE0VZV0.
KOiK11407.
OMAiQPHGFCI.
PhylomeDBiE0VZV0.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
PANTHERiPTHR10625. PTHR10625. 3 hits.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
PRINTSiPR01270. HDASUPER.
SMARTiView protein in SMART
SM00290. ZnF_UBP. 1 hit.
SUPFAMiSSF52768. SSF52768. 2 hits.
PROSITEiView protein in PROSITE
PS50271. ZF_UBP. 1 hit.

Sequencei

Sequence statusi: Complete.

E0VZV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSTSNKPL NRRSPRTCAA RTSSSILAAK ESMKMKMKKN QDDDFIRDDY
60 70 80 90 100
ATAQEAKTII AGKTGIVYDD QMVKHFCMWD KNYPENPERF SKIIERCKEL
110 120 130 140 150
KLIDRCTRIE SRLATEEEIL TQHTIDKIKV LKETQNENDE TKLEQLSSKY
160 170 180 190 200
DSVYVNNFTY ECSLLAVGST IDLVDAICKG EIQNGMAIIR PPGHHAMRDE
210 220 230 240 250
YCGYCFYNNV AIAAQLALKK FNLQRILIVD WDIHHGQATQ QMFYDDKRVV
260 270 280 290 300
YFSIHRYDHG SFWPELRESN FHYIGDSAGK GKNFNIPLNE TGMKDADYLA
310 320 330 340 350
IFQQVLLPMA YEFQPELIII SAGYDAAINC PEGSMEVSPA CYSHLLSPLM
360 370 380 390 400
GLAGGKVAVI LEGGYCLKSL SEGVALTLRT LLGDPAPSLI DFGLPCDSVV
410 420 430 440 450
ESILNVIYVH KPYWQCFQLQ DAYDVDVNEG GGIKTRKKST EKPSIAPTTK
460 470 480 490 500
RHHPVVKFIG NETKLDFYPT RDCYPIQEEE TFKKLDQKLN HLKLVTDLRV
510 520 530 540 550
PPNRVAFGYD EKMTEHRNNQ ESNHPEKPER ITKIFLMHRD YNLLERCLSI
560 570 580 590 600
KSRMATEEEI LLSHTNSHLE DMKKLPTMSA EELNEKGNSY DSIYLHSKSY
610 620 630 640 650
ECALLAAGTL LQVVDSVING EARSGVAVVR PPGHHAEDDT ACGFCLFNNV
660 670 680 690 700
SIAAKYAIEV HSLKRILVLD WDVHHGNGTQ KIFEEDDRVL YISLHRYNHG
710 720 730 740 750
RFFPTTKEGD HDRVGIGRGE GFNVNIPWNR PGGGMSDGDY IAAFHSIVLP
760 770 780 790 800
IAYQFNPELV LVSAGFDACI HDPLGHCKVT PEAYAHMTHW LTTLANGKVI
810 820 830 840 850
LSLEGGYNVT SISYALTLCT KALLGDPLPP LTTTLAPCSS AVETIQNVLN
860 870 880 890 900
TQEKYWPCLK FNVALPKDYV LKNSESNMGD SPKLVNNSYE KNEDLIEKMQ
910 920 930 940 950
SLKFENITLK GDQEVCDAPE DGNPRDARSR EGRSSRDSDH ESGAAARPNA
960 970 980 990 1000
QTLVVDPVII SSLRVVGLQE YTTTPGWFFF LLVSSSVQLV FFLLSSSVQF
1010 1020 1030 1040 1050
FFFFFSLKGY LSDNMQRLLN QEMFAVVPLP GCPHLVQVQA VPQSGIDVNT
1060 1070 1080 1090 1100
PCGTCDSQQE NWICLICYLV FCGRYINQHM MFHNEESTHP LALSFTDLSV
1110 1120 1130 1140
WCYVCEAYID NMILYPAKNA VHRSKFGSDL EWSYGDRTPN TRLSNR
Length:1,146
Mass (Da):129,337
Last modified:November 2, 2010 - v1
Checksum:iA3809B9688E520E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235854 Genomic DNA. Translation: EEB18906.1.
RefSeqiXP_002431644.1. XM_002431599.1.

Genome annotation databases

EnsemblMetazoaiPHUM538580-RA; PHUM538580-PA; PHUM538580.
GeneIDi8235461.
KEGGiphu:Phum_PHUM538580.
VectorBaseiPHUM538580-RA; PHUM538580-PA; PHUM538580.

Similar proteinsi

Entry informationi

Entry nameiE0VZV0_PEDHC
AccessioniPrimary (citable) accession number: E0VZV0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: November 22, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported