ID   E0VYZ7_PEDHC            Unreviewed;       664 AA.
AC   E0VYZ7;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=8231723 {ECO:0000313|EnsemblMetazoa:PHUM522390-PA};
GN   ORFNames=Phum_PHUM522390 {ECO:0000313|EMBL:EEB18603.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB18603.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB18603.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB18603.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB18603.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:PHUM522390-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM522390-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|ARBA:ARBA00008139, ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; AAZO01006341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235848; EEB18603.1; -; Genomic_DNA.
DR   RefSeq; XP_002431341.1; XM_002431296.1.
DR   AlphaFoldDB; E0VYZ7; -.
DR   STRING; 121224.E0VYZ7; -.
DR   EnsemblMetazoa; PHUM522390-RA; PHUM522390-PA; PHUM522390.
DR   GeneID; 8231723; -.
DR   KEGG; phu:Phum_PHUM522390; -.
DR   CTD; 8231723; -.
DR   VEuPathDB; VectorBase:PHUM522390; -.
DR   eggNOG; KOG3690; Eukaryota.
DR   HOGENOM; CLU_014364_3_3_1; -.
DR   InParanoid; E0VYZ7; -.
DR   OMA; ANHNYGP; -.
DR   OrthoDB; 2898149at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06461; M2_ACE; 1.
DR   Gene3D; 1.10.1370.30; -; 1.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   PANTHER; PTHR10514:SF40; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144,
KW   ECO:0000313|EMBL:EEB18603.1};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144, ECO:0000313|EMBL:EEB18603.1};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   REGION          27..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   664 AA;  77728 MW;  BB96F343075F3A57 CRC64;
     MSVLTSGRGY DSQPPVYLYG QQGTTATTTT TTTNSYQTNT RYDPSQNQYY DDNFKNVSYN
     VDPSPFGQNN QNVFIPIHEL MLLLSNLDNV GSEQCSANVY AQWEYETNVN DITQINALSA
     QQNHAAFDRE ISEILKQIQY NKFYNSKLWR ELRYLSVVGA AALPIDDYER YNRMISEMVA
     VYGRASICAY NEPFRCNLRL SPDLTVIMAR SRDWDELQHT WVEFRRRTGQ YIKDMYDQLV
     DLTNEAAKLN NFTDAEEMWN FPYDSPNFEQ EIEEVWSQIR PLYEQLHAYV RRKLRDLYGP
     EKISNRAPLP SHILGNMWAQ SWTNILDVTL PYPGKTLLDV TPNMQIQGYT PLTMLQLAEE
     FFISMNLSAM PPEFWAGSII TEIPERVINC QASAWDFCNR QDYRLKMCAK VNMKDFVSMH
     HEMGHIQYFL QYKNQPKVFR DGANPGFHEA IGEMIALSVG GPTHLQKLGL IQTSIDDVPL
     DINYLFSLAM DKLPFLPFAY VMDKWRWDVF KRVVSKEQFN CHWHSLRERY LGVKPPLLRS
     EFDFDPGSKY HIPANVPYIR YFFSTVLQFQ LHRHLCRISG QYDPNDSTKS LHKCDIYRKI
     QAGNVLKELM KYGSSLSWKE VLYRSIGENK LDGSALRDFF RPLEEWLRNE NLRRNEYPGW
     IYGK
//