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Protein
Submitted name:

Angiotensin-converting enzyme, putative

Gene

Phum_PHUM522390

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
  4. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotationImported, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM02.005.

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin-converting enzyme, putativeImported (EC:3.4.15.1Imported)
Gene namesi
ORF Names:Phum_PHUM522390Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE0VYZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Phylogenomic databases

InParanoidiE0VYZ7.
KOiK01283.
OMAiCKRSIET.
OrthoDBiEOG7N37C7.
PhylomeDBiE0VYZ7.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

E0VYZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLTSGRGY DSQPPVYLYG QQGTTATTTT TTTNSYQTNT RYDPSQNQYY
60 70 80 90 100
DDNFKNVSYN VDPSPFGQNN QNVFIPIHEL MLLLSNLDNV GSEQCSANVY
110 120 130 140 150
AQWEYETNVN DITQINALSA QQNHAAFDRE ISEILKQIQY NKFYNSKLWR
160 170 180 190 200
ELRYLSVVGA AALPIDDYER YNRMISEMVA VYGRASICAY NEPFRCNLRL
210 220 230 240 250
SPDLTVIMAR SRDWDELQHT WVEFRRRTGQ YIKDMYDQLV DLTNEAAKLN
260 270 280 290 300
NFTDAEEMWN FPYDSPNFEQ EIEEVWSQIR PLYEQLHAYV RRKLRDLYGP
310 320 330 340 350
EKISNRAPLP SHILGNMWAQ SWTNILDVTL PYPGKTLLDV TPNMQIQGYT
360 370 380 390 400
PLTMLQLAEE FFISMNLSAM PPEFWAGSII TEIPERVINC QASAWDFCNR
410 420 430 440 450
QDYRLKMCAK VNMKDFVSMH HEMGHIQYFL QYKNQPKVFR DGANPGFHEA
460 470 480 490 500
IGEMIALSVG GPTHLQKLGL IQTSIDDVPL DINYLFSLAM DKLPFLPFAY
510 520 530 540 550
VMDKWRWDVF KRVVSKEQFN CHWHSLRERY LGVKPPLLRS EFDFDPGSKY
560 570 580 590 600
HIPANVPYIR YFFSTVLQFQ LHRHLCRISG QYDPNDSTKS LHKCDIYRKI
610 620 630 640 650
QAGNVLKELM KYGSSLSWKE VLYRSIGENK LDGSALRDFF RPLEEWLRNE
660
NLRRNEYPGW IYGK
Length:664
Mass (Da):77,728
Last modified:November 2, 2010 - v1
Checksum:iBB96F343075F3A57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235848 Genomic DNA. Translation: EEB18603.1.
RefSeqiXP_002431341.1. XM_002431296.1.

Genome annotation databases

EnsemblMetazoaiPHUM522390-RA; PHUM522390-PA; PHUM522390.
GeneIDi8231723.
KEGGiphu:Phum_PHUM522390.
VectorBaseiPHUM522390. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235848 Genomic DNA. Translation: EEB18603.1.
RefSeqiXP_002431341.1. XM_002431296.1.

3D structure databases

ProteinModelPortaliE0VYZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM02.005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM522390-RA; PHUM522390-PA; PHUM522390.
GeneIDi8231723.
KEGGiphu:Phum_PHUM522390.
VectorBaseiPHUM522390. Pediculus humanus.

Organism-specific databases

CTDi8231723.

Phylogenomic databases

InParanoidiE0VYZ7.
KOiK01283.
OMAiCKRSIET.
OrthoDBiEOG7N37C7.
PhylomeDBiE0VYZ7.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0VYZ7_PEDHC
AccessioniPrimary (citable) accession number: E0VYZ7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.