ID   E0VP88_PEDHC            Unreviewed;       574 AA.
AC   E0VP88;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=Neuroendocrine convertase 2, putative {ECO:0000313|EMBL:EEB15194.1};
DE            EC=3.4.21.94 {ECO:0000313|EMBL:EEB15194.1};
DE   Flags: Fragment;
GN   Name=8232027 {ECO:0000313|EnsemblMetazoa:PHUM354430-PA};
GN   ORFNames=Phum_PHUM354430 {ECO:0000313|EMBL:EEB15194.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB15194.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB15194.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB15194.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB15194.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:PHUM354430-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM354430-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC       {ECO:0000256|ARBA:ARBA00005325}.
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DR   EMBL; AAZO01004118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235357; EEB15194.1; -; Genomic_DNA.
DR   RefSeq; XP_002427932.1; XM_002427887.1.
DR   AlphaFoldDB; E0VP88; -.
DR   STRING; 121224.E0VP88; -.
DR   MEROPS; S08.109; -.
DR   EnsemblMetazoa; PHUM354430-RA; PHUM354430-PA; PHUM354430.
DR   GeneID; 8232027; -.
DR   KEGG; phu:Phum_PHUM354430; -.
DR   CTD; 8232027; -.
DR   VEuPathDB; VectorBase:PHUM354430; -.
DR   eggNOG; KOG3526; Eukaryota.
DR   HOGENOM; CLU_002976_4_4_1; -.
DR   InParanoid; E0VP88; -.
DR   OMA; LAKQWHS; -.
DR   OrthoDB; 5474719at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016486; P:peptide hormone processing; IEA:UniProt.
DR   CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR032815; S8_pro-domain.
DR   InterPro; IPR038466; S8_pro-domain_sf.
DR   PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR   PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          411..547
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   ACT_SITE        116
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        157
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        332
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EEB15194.1"
SQ   SEQUENCE   574 AA;  63522 MW;  0559C48F4D45C627 CRC64;
     VLGSKSEYHF INHAVPHARS RRSITHARKL KKDPQVVYAV QQVGFKREKR GFKPLKVENL
     VQFMRPQDDP TDPYFQFQWY LKNTGQNGGK PKLDLNVASA WAQGITGKNV TTAIMDDGVD
     YMHADLKHNY NARASYDFSS NDPYPYPRYT DDWFNSHGTR CAGEVAAARD NGVCGVGVAY
     DSKIAGIRML DQPYMTDLIE ANSMGHEPNL IDIYSASWGP TDDGKTVDGP RNATMRAIVR
     GVNEGRNGLG NIYVWASGDG GEDDDCNCDG YAASMWTISI NSAINDGQNA HYDESCSSTL
     ASTFSNGAKD PNTGVATTDL YGKCTTTHSG TSAAAPEAAG VFALALEANP ALTWRDIQHL
     TVLTSKRNSL FDAKGRFHWT MNGVGLEFNH LFGFGVLDAG AMVALAKQWQ MVPARYHCEA
     GNLIGAYEIH SSRSLRLKIK TTACLGSDTQ VSYLEHVQAV ITLNASRRGD VEMFLTSPMG
     TRSMILSKRS KDDDHRDGFI KWPFMTTHSW GEYPQGTWIL EVNFNSESPQ IGFLKEWTLM
     LHGTREPPYS GLKVSDSHSK LAIVKKAHEE NRKM
//