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Protein
Submitted name:

Neuroendocrine convertase 2, putative

Gene

Phum_PHUM354430

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.109.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 2, putativeImported (EC:3.4.21.94Imported)
Gene namesi
ORF Names:Phum_PHUM354430Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046: Partially assembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliE0VP88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Phylogenomic databases

InParanoidiE0VP88.
KOiK01360.
OMAiTDACQGK.
OrthoDBiEOG7BW0JD.
PhylomeDBiE0VP88.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E0VP88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLGSKSEYHF INHAVPHARS RRSITHARKL KKDPQVVYAV QQVGFKREKR
60 70 80 90 100
GFKPLKVENL VQFMRPQDDP TDPYFQFQWY LKNTGQNGGK PKLDLNVASA
110 120 130 140 150
WAQGITGKNV TTAIMDDGVD YMHADLKHNY NARASYDFSS NDPYPYPRYT
160 170 180 190 200
DDWFNSHGTR CAGEVAAARD NGVCGVGVAY DSKIAGIRML DQPYMTDLIE
210 220 230 240 250
ANSMGHEPNL IDIYSASWGP TDDGKTVDGP RNATMRAIVR GVNEGRNGLG
260 270 280 290 300
NIYVWASGDG GEDDDCNCDG YAASMWTISI NSAINDGQNA HYDESCSSTL
310 320 330 340 350
ASTFSNGAKD PNTGVATTDL YGKCTTTHSG TSAAAPEAAG VFALALEANP
360 370 380 390 400
ALTWRDIQHL TVLTSKRNSL FDAKGRFHWT MNGVGLEFNH LFGFGVLDAG
410 420 430 440 450
AMVALAKQWQ MVPARYHCEA GNLIGAYEIH SSRSLRLKIK TTACLGSDTQ
460 470 480 490 500
VSYLEHVQAV ITLNASRRGD VEMFLTSPMG TRSMILSKRS KDDDHRDGFI
510 520 530 540 550
KWPFMTTHSW GEYPQGTWIL EVNFNSESPQ IGFLKEWTLM LHGTREPPYS
560 570
GLKVSDSHSK LAIVKKAHEE NRKM
Length:574
Mass (Da):63,522
Last modified:November 2, 2010 - v1
Checksum:i0559C48F4D45C627
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235357 Genomic DNA. Translation: EEB15194.1.
RefSeqiXP_002427932.1. XM_002427887.1.

Genome annotation databases

EnsemblMetazoaiPHUM354430-RA; PHUM354430-PA; PHUM354430.
GeneIDi8232027.
KEGGiphu:Phum_PHUM354430.
VectorBaseiPHUM354430. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235357 Genomic DNA. Translation: EEB15194.1.
RefSeqiXP_002427932.1. XM_002427887.1.

3D structure databases

ProteinModelPortaliE0VP88.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS08.109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM354430-RA; PHUM354430-PA; PHUM354430.
GeneIDi8232027.
KEGGiphu:Phum_PHUM354430.
VectorBaseiPHUM354430. Pediculus humanus.

Organism-specific databases

CTDi8232027.

Phylogenomic databases

InParanoidiE0VP88.
KOiK01360.
OMAiTDACQGK.
OrthoDBiEOG7BW0JD.
PhylomeDBiE0VP88.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0VP88_PEDHC
AccessioniPrimary (citable) accession number: E0VP88
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.