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Protein

Histone-lysine N-methyltransferase

Gene

Phum_PHUM244720

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:Phum_PHUM244720Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

InParanoidiE0VJG1.
KOiK06101.
OrthoDBiEOG7ZPNJ4.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 4 hits.
SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0VJG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHNKGGPCV RSDILASTAW NALIHHPVED SDAEELPSTV DIDAIKGAPI
60 70 80 90 100
TGHTGHWNSL NSNITKSNVE EKNESDSDDD KKISDSNSRS SSDSQSEDSE
110 120 130 140 150
SGSCSWSSSS ESSSRSSSCS SQSAVQSRIS SPPSQTFSIR ESNFEQSSSR
160 170 180 190 200
SQTGTESDSC SSMKHEKFKL GQLYMDEKEK MKKPTKVKSR LRFSGINDAK
210 220 230 240 250
KKLHVDQGVD NKSLKETSMS SLKLTTSVTQ ISSTKKINKN GESKSSVNVK
260 270 280 290 300
SKNDNLKTFN CNKTEETSKS ISMCEGPIIV GNKLNDSKSL SKKFNGKSII
310 320 330 340 350
NKKLDSSTIK RDLDINKCCS IVMPSNKKLS EASKLRCVRK NTGSQYNKPQ
360 370 380 390 400
SAIKPEAYSE SSESENDCSK DEAAHYTALA QQLSHIGNSE TLSSMSEHLQ
410 420 430 440 450
VINQEDLAAI LPDVVTAENH GSFDGFEDVS LECGKNEKKN VNQDSGSDVE
460 470 480 490 500
LPDQIVNDAI KRIHIDSEEM ENSESEKGNQ SSSDEDVEFR RGYSSSLLQQ
510 520 530 540 550
FVEKTEILSA QCERLINVSR SRKIASQNSL LMENILERRI KRGRPPKIVK
560 570 580 590 600
NSTSNNVESA QVVLGSVDRT NNKLMPELEA YRLDSSLSNV SPDSGIQSVP
610 620 630 640 650
GSPVNENIHV SPCRDVTPPI LRPVTPVTGI PNKLSYLTKK SDISKKRPGR
660 670 680 690 700
PKKIKLEVFR NLLQNNNQSE TKKDKNVKSE DRPPIHSLIP ERRGPGRPKK
710 720 730 740 750
APPILEPNIP MVCRNELCKK ETRNNINIVL NEICERVSRQ LDFPSLSKES
760 770 780 790 800
MRNVELNKED IERILLHHKS KKSRNLKFDA IFSKSMRLSN PPNVAIVKPM
810 820 830 840 850
QHHRVEDNNV ENDKLNKKSG KKCKNGNLDE NTWYSVKLAC EKLNIAEKEK
860 870 880 890 900
DFTDKKSRSF MDEKLNKGNK CKKKTEGKSK TKDLGHKSVG FVSTPRTFPT
910 920 930 940 950
YKTLSTNDQL SKYFEKAKPN LQKKIHSLKK PRKNLKKSIK RKNGKTIHNL
960 970 980 990 1000
LHRKHKKCKR SMKHLKCKQK KLDNEWFFKE LEELITEFQK FSIGIVKKSI
1010 1020 1030 1040 1050
SLVTGNNLCT MQTVNSVQNE MGLPADFRVK RAVKKRKGSE KSRGSDRESG
1060 1070 1080 1090 1100
AEKSKLSDRE SGPELPENEV LREKPKRKQK KNHVEVINQG ADTNSNEQRL
1110 1120 1130 1140 1150
PLKKRHYHLT SASNQQLLPS WTSDSTQSIV KSINADKPIN KEVNSHLKKE
1160 1170 1180 1190 1200
AVEKIKCADS QKIQRNSIDE AIEATITRYT TKSCNVSPET NSDSNSTQSQ
1210 1220 1230 1240 1250
FNNQQCVITT PKKRHRVPDL VAKTVFQSNI CKNNNDVKSI LKNSDINVKT
1260 1270 1280 1290 1300
MLSLRHGAGN YTKVEPSCVQ NLIKTSNFIK ETNNKLFLPI ESKKKTGIKN
1310 1320 1330 1340 1350
ISKDIKGDKY VTGSTKGDIE KSDNDEIFTR NNDKIKKYGL KNSEHSEHLH
1360 1370 1380 1390 1400
FSKTSEERLK KYEFKNVLFE KTLSKTSQKQ HYTRSSSKTD MTPSDQTQSN
1410 1420 1430 1440 1450
NSKEVHLCKF NGSKESNEND HDDDKISEKL PEIEIFDSSL DAKYDGKTLS
1460 1470 1480 1490 1500
PTVNLQNEND KNSSNLKKYR DGRILQSVEE KRKDKSHKKL FTQKKGIRKS
1510 1520 1530 1540 1550
NYFKKPRCLK SCKEVRVNVK ESTPKDILIT KGVVEKKKVK RRKAINRTGF
1560 1570 1580 1590 1600
PSNKKKKKKM SIKLDEIEDK TASEMTKFSN PDGSATKLQE CETDKFSEDS
1610 1620 1630 1640 1650
NNKKNNLNLS TNTTDLNKSL DCPTNESVKT DDDENNLENN RGNQISLEET
1660 1670 1680 1690 1700
TVQDSITEER ESKVEGKVSE SSGTKRVRKN SSSLSDLVAK KVKTIKTENE
1710 1720 1730 1740 1750
EPKVKNNADL HKGIETTTGT ISTRKRKSLN TTKNINFGLN RYQYPLLSMK
1760 1770 1780 1790 1800
KFKRAKEELR AQSEESICDS VEEEVSKIKK SHPRWRKKYL AAGLFSDFYK
1810 1820 1830 1840 1850
QDPPQKVNKV NEKSLSKLVY LLADQELDLL PPPSYCNKYV RLRRVDYQLP
1860 1870 1880 1890 1900
FDLWWLHTHS QLPGRDIVPS WNYKKIRTNI YYDVKPQMTG TYEAQACNCT
1910 1920 1930 1940 1950
VPLNTKQKGC GEECINRMVF AECSPQLCPC KEKCSNQRIQ KHEFAPGLQK
1960 1970 1980 1990 2000
FMTKNKGWGI RTKQPIKAGD FILEYVGEVV SDKEFKDRMA SIYVNDKHHY
2010 2020 2030 2040 2050
CLHLDGGLVI DGHRMGGDGR FVNHSCNPNC EMQKWSVNGL FRMALFALRN
2060 2070 2080 2090 2100
IPAHQELTYD YNFSLFNPAE GQPCYCGTNE CRGVIGGKSQ RIPLGNGQNV
2110 2120 2130 2140 2150
VTSEKKEKKM VGRPRKTGKA KKHNVRDKNK IETVTVKPST KPMSHQQRCF
2160 2170 2180 2190 2200
VQMHHCFLLR NVDKVKRNKN NSKWNWKQSN NEVQSFSRQL PEIKQSDVFY
2210 2220 2230 2240 2250
TQLNALSTLR SIKTRRLAQA EDNPELTKVA KLAYIFKDLY SAVISAKDEK
2260 2270 2280 2290 2300
GELLSAPFTN LPPKRKLPAY YQRVSDPIDL ITIEQNINTG NYKTIEAFDQ
2310 2320 2330 2340 2350
DMTKLFNNNV KFYGRTSELG IASTRLRRVY CLAKYDSASE LEKVLGDAIP
2360 2370 2380 2390 2400
SSFIPENANP GDEEEDVIRC ICGLYKDEGV MIQCERCLVW QHCDCVKADD
2410 2420 2430 2440 2450
SVEHYLCERC DPREVNLEIL IDPQPEYATE DTTHYISLLR GDLQLRIGDA
2460 2470 2480 2490 2500
VYVLRDMIEE NTPKTSPPTK VTYKTIQNVN YADLDIFRIE RLWIDKKGDK
2510 2520 2530 2540 2550
FAFGHHYLRP HETYHEPTRK FFHNEVMRVP LYEVVPLDLI MNHCWVLDLN
2560 2570 2580 2590 2600
TYCKGRPIGA PEEHIYICEY RVDKSAHLFA KIAKPYLICT KTYAFEKFDV
2610 2620 2630 2640 2650
RLKPTRTYTV HEAKSESLKQ SESDEELPLA KIKENVHAAK RDEQKKRLNS
2660 2670 2680
ILLKLLSRLP NKQPLDLSYL LEPVKRFRGK AQQQGKRT
Length:2,688
Mass (Da):306,122
Last modified:November 2, 2010 - v1
Checksum:iB999A46F4626BEFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235222 Genomic DNA. Translation: EEB13517.1.
RefSeqiXP_002426255.1. XM_002426210.1.

Genome annotation databases

EnsemblMetazoaiPHUM244720-RA; PHUM244720-PA; PHUM244720.
GeneIDi8230790.
KEGGiphu:Phum_PHUM244720.
VectorBaseiPHUM244720. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235222 Genomic DNA. Translation: EEB13517.1.
RefSeqiXP_002426255.1. XM_002426210.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM244720-RA; PHUM244720-PA; PHUM244720.
GeneIDi8230790.
KEGGiphu:Phum_PHUM244720.
VectorBaseiPHUM244720. Pediculus humanus.

Organism-specific databases

CTDi8230790.

Phylogenomic databases

InParanoidiE0VJG1.
KOiK06101.
OrthoDBiEOG7ZPNJ4.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 4 hits.
SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0VJG1_PEDHC
AccessioniPrimary (citable) accession number: E0VJG1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: March 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.