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Protein

DNA ligase

Gene

Phum_PHUM186980

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Phum_PHUM186980Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046: Partially assembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiE0VGK6.
KOiK10776.
OMAiLFSEMKH.
OrthoDBiEOG7BKCT2.
PhylomeDBiE0VGK6.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0VGK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKEDEEQP SEKPFHVDRA KTGRAGCKKC KQKISQGELR MAKLAYNPFG
60 70 80 90 100
TGTIKQWHHI QCIFDVFKKQ RATTKKIEHP DEIGGWDNLN ENDQQEIINY
110 120 130 140 150
FPPELQKIFE SASRETLNAT LQHKDSLNKI IEKKFANHKD NSFKMFRKIC
160 170 180 190 200
VDLANDSSYL TKTKIVADFF NKGSDGESFK SDYELWCRLL LPGAVIRVYN
210 220 230 240 250
LQSKQLIKLF SKILGVDHDA MLEDLEKGDV AETISSFFKT STKIKEANKS
260 270 280 290 300
TLTLQEVDEF LEKLSKMTKE DEQNYHFKGI TKKCTANDLK MIIRLIKHDL
310 320 330 340 350
RINAGPKHIL EALHKDAYKA FQTSRDIKSV VYNAIKAREK NNNKKNEKLN
360 370 380 390 400
SEKGMDISIN MMTPVLPMLA QPCKSVEMAL EKCPNGMFSE IKYDGERVQL
410 420 430 440 450
HKLGDTFKYF SRSLKPVLAH KVSHFKEYIP QAFPYGKDLI LDAEILMVDN
460 470 480 490 500
NTGKPLPFGT LGIHKKSEFK NANVCLFVFD CMYYNGQSLL TTCLSERKSI
510 520 530 540 550
LRQNMVEINN HIMFSEMEEI NRAEDLEEMI TKVFKQGLEG LVLKDKKSVY
560 570 580 590 600
EPGKRHWLKV KKDYLCDGAM ADSADLVVLG AWFGTGHKGG IMSSFLMGCY
610 620 630 640 650
DAKSKKWVTV TKVSSGHDEQ TLDRIQKELS VVKISKDPSK VPNWLNCTKT
660 670 680 690 700
MIPDFVANDP KKMPVWEITG AEFTCNQVHT ANGISIRFPR VTKIRSDKDW
710 720 730 740 750
ASATNLSELK KLFKKSKDTS NFSLLNTSRS SSSTGGETTG DDGTPKKLKK
760 770 780 790 800
RKNDDDDEKK TDTTTVKKSR KADENVEAYF EETDTEEEEE KNPSENSESK
810 820 830 840 850
EKSFSNPLPN IFTGCVIQIP KEYKNYDLLR RYLIAYDGKL YDPEKETSVE
860 870 880 890 900
NGKNKVTHVI HLNKVGKIVK NEKYWDKGVR HVHVNWIWNS IKLLDKQPES
910 920
CHVVTVEQKS GYRYNFKKCY LLNQKNK
Length:927
Mass (Da):106,343
Last modified:November 2, 2010 - v1
Checksum:i2F080EA933FFE744
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235148 Genomic DNA. Translation: EEB12512.1.
RefSeqiXP_002425250.1. XM_002425205.1.

Genome annotation databases

EnsemblMetazoaiPHUM186980-RA; PHUM186980-PA; PHUM186980.
GeneIDi8240034.
KEGGiphu:Phum_PHUM186980.
VectorBaseiPHUM186980. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235148 Genomic DNA. Translation: EEB12512.1.
RefSeqiXP_002425250.1. XM_002425205.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM186980-RA; PHUM186980-PA; PHUM186980.
GeneIDi8240034.
KEGGiphu:Phum_PHUM186980.
VectorBaseiPHUM186980. Pediculus humanus.

Organism-specific databases

CTDi8240034.

Phylogenomic databases

InParanoidiE0VGK6.
KOiK10776.
OMAiLFSEMKH.
OrthoDBiEOG7BKCT2.
PhylomeDBiE0VGK6.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0VGK6_PEDHC
AccessioniPrimary (citable) accession number: E0VGK6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.