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E0VGK6

- E0VGK6_PEDHC

UniProt

E0VGK6 - E0VGK6_PEDHC

Protein

DNA ligase

Gene

Phum_PHUM186980

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:Phum_PHUM186980Imported
    OrganismiPediculus humanus subsp. corporis (Body louse)Imported
    Taxonomic identifieri121224 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
    ProteomesiUP000009046: Partially assembled WGS sequence

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK10776.
    OMAiLFSEMKH.
    OrthoDBiEOG7BKCT2.
    PhylomeDBiE0VGK6.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    3.40.50.10190. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0VGK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKEDEEQP SEKPFHVDRA KTGRAGCKKC KQKISQGELR MAKLAYNPFG    50
    TGTIKQWHHI QCIFDVFKKQ RATTKKIEHP DEIGGWDNLN ENDQQEIINY 100
    FPPELQKIFE SASRETLNAT LQHKDSLNKI IEKKFANHKD NSFKMFRKIC 150
    VDLANDSSYL TKTKIVADFF NKGSDGESFK SDYELWCRLL LPGAVIRVYN 200
    LQSKQLIKLF SKILGVDHDA MLEDLEKGDV AETISSFFKT STKIKEANKS 250
    TLTLQEVDEF LEKLSKMTKE DEQNYHFKGI TKKCTANDLK MIIRLIKHDL 300
    RINAGPKHIL EALHKDAYKA FQTSRDIKSV VYNAIKAREK NNNKKNEKLN 350
    SEKGMDISIN MMTPVLPMLA QPCKSVEMAL EKCPNGMFSE IKYDGERVQL 400
    HKLGDTFKYF SRSLKPVLAH KVSHFKEYIP QAFPYGKDLI LDAEILMVDN 450
    NTGKPLPFGT LGIHKKSEFK NANVCLFVFD CMYYNGQSLL TTCLSERKSI 500
    LRQNMVEINN HIMFSEMEEI NRAEDLEEMI TKVFKQGLEG LVLKDKKSVY 550
    EPGKRHWLKV KKDYLCDGAM ADSADLVVLG AWFGTGHKGG IMSSFLMGCY 600
    DAKSKKWVTV TKVSSGHDEQ TLDRIQKELS VVKISKDPSK VPNWLNCTKT 650
    MIPDFVANDP KKMPVWEITG AEFTCNQVHT ANGISIRFPR VTKIRSDKDW 700
    ASATNLSELK KLFKKSKDTS NFSLLNTSRS SSSTGGETTG DDGTPKKLKK 750
    RKNDDDDEKK TDTTTVKKSR KADENVEAYF EETDTEEEEE KNPSENSESK 800
    EKSFSNPLPN IFTGCVIQIP KEYKNYDLLR RYLIAYDGKL YDPEKETSVE 850
    NGKNKVTHVI HLNKVGKIVK NEKYWDKGVR HVHVNWIWNS IKLLDKQPES 900
    CHVVTVEQKS GYRYNFKKCY LLNQKNK 927
    Length:927
    Mass (Da):106,343
    Last modified:November 2, 2010 - v1
    Checksum:i2F080EA933FFE744
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS235148 Genomic DNA. Translation: EEB12512.1.
    RefSeqiXP_002425250.1. XM_002425205.1.

    Genome annotation databases

    GeneIDi8240034.
    KEGGiphu:Phum_PHUM186980.
    VectorBaseiPHUM186980. Pediculus humanus.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS235148 Genomic DNA. Translation: EEB12512.1 .
    RefSeqi XP_002425250.1. XM_002425205.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8240034.
    KEGGi phu:Phum_PHUM186980.
    VectorBasei PHUM186980. Pediculus humanus.

    Organism-specific databases

    CTDi 8240034.

    Phylogenomic databases

    KOi K10776.
    OMAi LFSEMKH.
    OrthoDBi EOG7BKCT2.
    PhylomeDBi E0VGK6.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    3.40.50.10190. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
      Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
      , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
      Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: USDAImported.

    Entry informationi

    Entry nameiE0VGK6_PEDHC
    AccessioniPrimary (citable) accession number: E0VGK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3