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E0VGK6

- E0VGK6_PEDHC

UniProt

E0VGK6 - E0VGK6_PEDHC

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Protein

DNA ligase

Gene
Phum_PHUM186980
Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Phum_PHUM186980Imported
OrganismiPediculus humanus subsp. corporis (Body louse)
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046: Partially assembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10776.
OMAiLFSEMKH.
OrthoDBiEOG7BKCT2.
PhylomeDBiE0VGK6.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0VGK6-1 [UniParc]FASTAAdd to Basket

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MSDKEDEEQP SEKPFHVDRA KTGRAGCKKC KQKISQGELR MAKLAYNPFG    50
TGTIKQWHHI QCIFDVFKKQ RATTKKIEHP DEIGGWDNLN ENDQQEIINY 100
FPPELQKIFE SASRETLNAT LQHKDSLNKI IEKKFANHKD NSFKMFRKIC 150
VDLANDSSYL TKTKIVADFF NKGSDGESFK SDYELWCRLL LPGAVIRVYN 200
LQSKQLIKLF SKILGVDHDA MLEDLEKGDV AETISSFFKT STKIKEANKS 250
TLTLQEVDEF LEKLSKMTKE DEQNYHFKGI TKKCTANDLK MIIRLIKHDL 300
RINAGPKHIL EALHKDAYKA FQTSRDIKSV VYNAIKAREK NNNKKNEKLN 350
SEKGMDISIN MMTPVLPMLA QPCKSVEMAL EKCPNGMFSE IKYDGERVQL 400
HKLGDTFKYF SRSLKPVLAH KVSHFKEYIP QAFPYGKDLI LDAEILMVDN 450
NTGKPLPFGT LGIHKKSEFK NANVCLFVFD CMYYNGQSLL TTCLSERKSI 500
LRQNMVEINN HIMFSEMEEI NRAEDLEEMI TKVFKQGLEG LVLKDKKSVY 550
EPGKRHWLKV KKDYLCDGAM ADSADLVVLG AWFGTGHKGG IMSSFLMGCY 600
DAKSKKWVTV TKVSSGHDEQ TLDRIQKELS VVKISKDPSK VPNWLNCTKT 650
MIPDFVANDP KKMPVWEITG AEFTCNQVHT ANGISIRFPR VTKIRSDKDW 700
ASATNLSELK KLFKKSKDTS NFSLLNTSRS SSSTGGETTG DDGTPKKLKK 750
RKNDDDDEKK TDTTTVKKSR KADENVEAYF EETDTEEEEE KNPSENSESK 800
EKSFSNPLPN IFTGCVIQIP KEYKNYDLLR RYLIAYDGKL YDPEKETSVE 850
NGKNKVTHVI HLNKVGKIVK NEKYWDKGVR HVHVNWIWNS IKLLDKQPES 900
CHVVTVEQKS GYRYNFKKCY LLNQKNK 927
Length:927
Mass (Da):106,343
Last modified:November 2, 2010 - v1
Checksum:i2F080EA933FFE744
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS235148 Genomic DNA. Translation: EEB12512.1.
RefSeqiXP_002425250.1. XM_002425205.1.

Genome annotation databases

GeneIDi8240034.
KEGGiphu:Phum_PHUM186980.
VectorBaseiPHUM186980. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS235148 Genomic DNA. Translation: EEB12512.1 .
RefSeqi XP_002425250.1. XM_002425205.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8240034.
KEGGi phu:Phum_PHUM186980.
VectorBasei PHUM186980. Pediculus humanus.

Organism-specific databases

CTDi 8240034.

Phylogenomic databases

KOi K10776.
OMAi LFSEMKH.
OrthoDBi EOG7BKCT2.
PhylomeDBi E0VGK6.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDA.

Entry informationi

Entry nameiE0VGK6_PEDHC
AccessioniPrimary (citable) accession number: E0VGK6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3