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Protein

DNA ligase

Gene

8240034

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:8240034Imported
ORF Names:Phum_PHUM186980Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPsocodeaPhthirapteraAnopluraPediculidaePediculus
Proteomesi
  • UP000009046 Componenti: Partially assembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi121225.PHUM186980-PA

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 102PARP-typeInterPro annotationAdd BLAST88
Domaini467 – 601DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini807 – 892BRCTInterPro annotationAdd BLAST86

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiE0VGK6
KOiK10776
OMAiDCIYFND
PhylomeDBiE0VGK6

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

E0VGK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKEDEEQP SEKPFHVDRA KTGRAGCKKC KQKISQGELR MAKLAYNPFG
60 70 80 90 100
TGTIKQWHHI QCIFDVFKKQ RATTKKIEHP DEIGGWDNLN ENDQQEIINY
110 120 130 140 150
FPPELQKIFE SASRETLNAT LQHKDSLNKI IEKKFANHKD NSFKMFRKIC
160 170 180 190 200
VDLANDSSYL TKTKIVADFF NKGSDGESFK SDYELWCRLL LPGAVIRVYN
210 220 230 240 250
LQSKQLIKLF SKILGVDHDA MLEDLEKGDV AETISSFFKT STKIKEANKS
260 270 280 290 300
TLTLQEVDEF LEKLSKMTKE DEQNYHFKGI TKKCTANDLK MIIRLIKHDL
310 320 330 340 350
RINAGPKHIL EALHKDAYKA FQTSRDIKSV VYNAIKAREK NNNKKNEKLN
360 370 380 390 400
SEKGMDISIN MMTPVLPMLA QPCKSVEMAL EKCPNGMFSE IKYDGERVQL
410 420 430 440 450
HKLGDTFKYF SRSLKPVLAH KVSHFKEYIP QAFPYGKDLI LDAEILMVDN
460 470 480 490 500
NTGKPLPFGT LGIHKKSEFK NANVCLFVFD CMYYNGQSLL TTCLSERKSI
510 520 530 540 550
LRQNMVEINN HIMFSEMEEI NRAEDLEEMI TKVFKQGLEG LVLKDKKSVY
560 570 580 590 600
EPGKRHWLKV KKDYLCDGAM ADSADLVVLG AWFGTGHKGG IMSSFLMGCY
610 620 630 640 650
DAKSKKWVTV TKVSSGHDEQ TLDRIQKELS VVKISKDPSK VPNWLNCTKT
660 670 680 690 700
MIPDFVANDP KKMPVWEITG AEFTCNQVHT ANGISIRFPR VTKIRSDKDW
710 720 730 740 750
ASATNLSELK KLFKKSKDTS NFSLLNTSRS SSSTGGETTG DDGTPKKLKK
760 770 780 790 800
RKNDDDDEKK TDTTTVKKSR KADENVEAYF EETDTEEEEE KNPSENSESK
810 820 830 840 850
EKSFSNPLPN IFTGCVIQIP KEYKNYDLLR RYLIAYDGKL YDPEKETSVE
860 870 880 890 900
NGKNKVTHVI HLNKVGKIVK NEKYWDKGVR HVHVNWIWNS IKLLDKQPES
910 920
CHVVTVEQKS GYRYNFKKCY LLNQKNK
Length:927
Mass (Da):106,343
Last modified:November 2, 2010 - v1
Checksum:i2F080EA933FFE744
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235148 Genomic DNA Translation: EEB12512.1
RefSeqiXP_002425250.1, XM_002425205.1

Genome annotation databases

EnsemblMetazoaiPHUM186980-RA; PHUM186980-PA; PHUM186980
GeneIDi8240034
KEGGiphu:Phum_PHUM186980
VectorBaseiPHUM186980-RA; PHUM186980-PA; PHUM186980

Similar proteinsi

Entry informationi

Entry nameiE0VGK6_PEDHC
AccessioniPrimary (citable) accession number: E0VGK6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health