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Protein

DNA ligase

Gene

Phum_PHUM175060

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Phum_PHUM175060Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046 Componenti: Partially assembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliE0VG84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiE0VG84.
KOiK10747.
OMAiPQVVIEV.
OrthoDBiEOG7RFTGN.
PhylomeDBiE0VG84.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0VG84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETTITPNQ EYKIVSNTKS YDIISKFFLI SSADENSPIK ATGSKKRLRI
60 70 80 90 100
SSSSSDKDSE TDDLETTEKK SVDSRIKKTS QKVAKLTTSS KVNPLQSSDN
110 120 130 140 150
SITDKKDNLD KKNCTNIEKS NNITSESKTE KVEKTNKKDS SPVKEKVSKC
160 170 180 190 200
NVLVEDYNPT LPKYHPIKNA CWEYGEKVPY YALTKTFEEI EKVSARLKMI
210 220 230 240 250
EILSNFLRSV IVLTPDDLLP CIYLSLNKLG PAHEGLELGL AEQTLIRVIS
260 270 280 290 300
QSTGRTEVGD LGLVAEKSRT SQKLMFKPSP LNVNGVFKKF TEIANLTGKD
310 320 330 340 350
SVNKKISMVS NLFTACKGPE AKFLMRSLNG KLRIACATTP PGQKYPPKNL
360 370 380 390 400
DVSSTMSPDT FKSHVDELAL ILKTTYCECP NYGMLVPVLL KEGISALPKH
410 420 430 440 450
CKITPGLPMK PMLAQPTKGV QEVLTRFEDM EFTCEWKYDG ERAQIHYLEN
460 470 480 490 500
GKVKIFSRNQ EDNTSKYPDI ISRIQQVKKD SVTSFILDCE AVAWDKENNA
510 520 530 540 550
ILPFQVLIKR KRKDVAESDI KVPVCVYMFD LLYLNGKPLV KEKFIDRRRL
560 570 580 590 600
LQENFNEVLG EWTFAKSIDT TKMEEVQEFL EESIKGNCEG LMVKTLREEA
610 620 630 640 650
TYEIAKRSKN WLKLKKDYLE GVGDTLDLVV LGGYLGKGKR TGTYGGFLIG
660 670 680 690 700
CYDNDNEEYQ SICKLGTGFS DESLAQHTEF FKPHVITQAP SYYQYDTSME
710 720 730 740 750
PDHWFEPIQV WETKCADFSL SPIHRAAVGV VDPVKGISLR FPRFLRIRDD
760 770 780
KKPEDATTAQ QIIDLYHNQE QVKCQNSVKF QEEDFY
Length:786
Mass (Da):89,086
Last modified:November 2, 2010 - v1
Checksum:i234F6D739D7B1CFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235132 Genomic DNA. Translation: EEB12390.1.
RefSeqiXP_002425128.1. XM_002425083.1.

Genome annotation databases

EnsemblMetazoaiPHUM175060-RA; PHUM175060-PA; PHUM175060.
GeneIDi8236783.
KEGGiphu:Phum_PHUM175060.
VectorBaseiPHUM175060. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235132 Genomic DNA. Translation: EEB12390.1.
RefSeqiXP_002425128.1. XM_002425083.1.

3D structure databases

ProteinModelPortaliE0VG84.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM175060-RA; PHUM175060-PA; PHUM175060.
GeneIDi8236783.
KEGGiphu:Phum_PHUM175060.
VectorBaseiPHUM175060. Pediculus humanus.

Organism-specific databases

CTDi8236783.

Phylogenomic databases

InParanoidiE0VG84.
KOiK10747.
OMAiPQVVIEV.
OrthoDBiEOG7RFTGN.
PhylomeDBiE0VG84.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0VG84_PEDHC
AccessioniPrimary (citable) accession number: E0VG84
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.