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E0VG84

- E0VG84_PEDHC

UniProt

E0VG84 - E0VG84_PEDHC

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Protein

DNA ligase

Gene
Phum_PHUM175060
Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Phum_PHUM175060Imported
OrganismiPediculus humanus subsp. corporis (Body louse)
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046: Partially assembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliE0VG84.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiLDPSGYN.
OrthoDBiEOG7RFTGN.
PhylomeDBiE0VG84.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0VG84-1 [UniParc]FASTAAdd to Basket

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MGETTITPNQ EYKIVSNTKS YDIISKFFLI SSADENSPIK ATGSKKRLRI    50
SSSSSDKDSE TDDLETTEKK SVDSRIKKTS QKVAKLTTSS KVNPLQSSDN 100
SITDKKDNLD KKNCTNIEKS NNITSESKTE KVEKTNKKDS SPVKEKVSKC 150
NVLVEDYNPT LPKYHPIKNA CWEYGEKVPY YALTKTFEEI EKVSARLKMI 200
EILSNFLRSV IVLTPDDLLP CIYLSLNKLG PAHEGLELGL AEQTLIRVIS 250
QSTGRTEVGD LGLVAEKSRT SQKLMFKPSP LNVNGVFKKF TEIANLTGKD 300
SVNKKISMVS NLFTACKGPE AKFLMRSLNG KLRIACATTP PGQKYPPKNL 350
DVSSTMSPDT FKSHVDELAL ILKTTYCECP NYGMLVPVLL KEGISALPKH 400
CKITPGLPMK PMLAQPTKGV QEVLTRFEDM EFTCEWKYDG ERAQIHYLEN 450
GKVKIFSRNQ EDNTSKYPDI ISRIQQVKKD SVTSFILDCE AVAWDKENNA 500
ILPFQVLIKR KRKDVAESDI KVPVCVYMFD LLYLNGKPLV KEKFIDRRRL 550
LQENFNEVLG EWTFAKSIDT TKMEEVQEFL EESIKGNCEG LMVKTLREEA 600
TYEIAKRSKN WLKLKKDYLE GVGDTLDLVV LGGYLGKGKR TGTYGGFLIG 650
CYDNDNEEYQ SICKLGTGFS DESLAQHTEF FKPHVITQAP SYYQYDTSME 700
PDHWFEPIQV WETKCADFSL SPIHRAAVGV VDPVKGISLR FPRFLRIRDD 750
KKPEDATTAQ QIIDLYHNQE QVKCQNSVKF QEEDFY 786
Length:786
Mass (Da):89,086
Last modified:November 2, 2010 - v1
Checksum:i234F6D739D7B1CFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS235132 Genomic DNA. Translation: EEB12390.1.
RefSeqiXP_002425128.1. XM_002425083.1.

Genome annotation databases

GeneIDi8236783.
KEGGiphu:Phum_PHUM175060.
VectorBaseiPHUM175060. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS235132 Genomic DNA. Translation: EEB12390.1 .
RefSeqi XP_002425128.1. XM_002425083.1.

3D structure databases

ProteinModelPortali E0VG84.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8236783.
KEGGi phu:Phum_PHUM175060.
VectorBasei PHUM175060. Pediculus humanus.

Organism-specific databases

CTDi 8236783.

Phylogenomic databases

KOi K10747.
OMAi LDPSGYN.
OrthoDBi EOG7RFTGN.
PhylomeDBi E0VG84.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDA.

Entry informationi

Entry nameiE0VG84_PEDHC
AccessioniPrimary (citable) accession number: E0VG84
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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