ID   E0VFI7_PEDHC            Unreviewed;       532 AA.
AC   E0VFI7;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Cysteine sulfinic acid decarboxylase, putative {ECO:0000313|EMBL:EEB12143.1, ECO:0000313|EnsemblMetazoa:PHUM157900-PA};
DE            EC=4.1.1.29 {ECO:0000313|EMBL:EEB12143.1};
GN   Name=8236532 {ECO:0000313|EnsemblMetazoa:PHUM157900-PA};
GN   ORFNames=Phum_PHUM157900 {ECO:0000313|EMBL:EEB12143.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB12143.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB12143.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB12143.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB12143.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:PHUM157900-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM157900-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; AAZO01001844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235113; EEB12143.1; -; Genomic_DNA.
DR   RefSeq; XP_002424881.1; XM_002424836.1.
DR   AlphaFoldDB; E0VFI7; -.
DR   STRING; 121224.E0VFI7; -.
DR   EnsemblMetazoa; PHUM157900-RA; PHUM157900-PA; PHUM157900.
DR   GeneID; 8236532; -.
DR   KEGG; phu:Phum_PHUM157900; -.
DR   CTD; 8236532; -.
DR   VEuPathDB; VectorBase:PHUM157900; -.
DR   eggNOG; KOG0629; Eukaryota.
DR   HOGENOM; CLU_011856_0_0_1; -.
DR   InParanoid; E0VFI7; -.
DR   OMA; NWQPLMV; -.
DR   OrthoDB; 888358at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0004782; F:sulfinoalanine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.170; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR45677:SF12; BLACK, ISOFORM A; 1.
DR   PANTHER; PTHR45677; GLUTAMATE DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046}.
FT   MOD_RES         347
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   532 AA;  60456 MW;  B3AB1B041132C7FB CRC64;
     MFPVISTQKQ SFGIINLSLL EDNNFLIKTN SVVDKSDKED EKLNQKHWSL PLEKYHYDFI
     VKCVGIIMKE AVFDGTNRNS KVVQWQDPEK LKKSFDFSLN KYSETEGKLL HLISTIIKFS
     VKTGHPYFVN QLFSGVDPYG LIGQWLTDAL NPSVYTYEVS PVFSIMEEVV LEEMRKFIGF
     PNGKGDGTFC PGGSISNGFG ISCARYHLFP QVKKLGIYGI GLRLVLFTSR DAHYSIVKLA
     TFMGLGSDNV ISIKTDESGK MKPEELEKAI LKVLQEGGTP FMVSATSGTT VLGAFDPLDS
     IADICEKYKL WFHVDAAWGG GCLMSSIHKK KLQGIHRTDS VTWNPHKLLG VPQQCSAFLT
     KHKNLLKNVH CAKATYLFQK DKFYDVKYDT GDKHIQCGRR ADVLKFWFMW KAKGSSGFEK
     HINKIFETAL YFKKSIENKP DFQLVLSEPE CTNICFWYIP PRLQNSKYNN DDLNKVAPRM
     KEKMMKDGSM MITYQPLRHL PNFFRLVIVN SGLDTHDMDR LITIIQNAGA SI
//