ID   E0VC46_PEDHC            Unreviewed;      3311 AA.
AC   E0VC46;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   RecName: Full=DNA-directed RNA polymerase II subunit RPB7 {ECO:0000256|ARBA:ARBA00015928};
GN   Name=8231358 {ECO:0000313|EnsemblMetazoa:PHUM079870-PA};
GN   ORFNames=Phum_PHUM079870 {ECO:0000313|EMBL:EEB10952.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC   Pediculus.
OX   NCBI_TaxID=121224;
RN   [1] {ECO:0000313|EMBL:EEB10952.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB10952.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB10952.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB10952.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:PHUM079870-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM079870-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SUBUNIT: Component of the RNA polymerase II (Pol II) complex consisting
CC       of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the
CC       10-subunit Pol II core complex. {ECO:0000256|ARBA:ARBA00025894}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AAZO01000953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS235047; EEB10952.1; -; Genomic_DNA.
DR   RefSeq; XP_002423690.1; XM_002423645.1.
DR   STRING; 121224.E0VC46; -.
DR   EnsemblMetazoa; PHUM079870-RA; PHUM079870-PA; PHUM079870.
DR   GeneID; 8231358; -.
DR   KEGG; phu:Phum_PHUM079870; -.
DR   CTD; 8231358; -.
DR   VEuPathDB; VectorBase:PHUM079870; -.
DR   eggNOG; KOG1084; Eukaryota.
DR   eggNOG; KOG3298; Eukaryota.
DR   HOGENOM; CLU_225836_0_0_1; -.
DR   InParanoid; E0VC46; -.
DR   OMA; DTKMMEC; -.
DR   OrthoDB; 5490909at2759; -.
DR   Proteomes; UP000009046; Unassembled WGS sequence.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd15506; PHD1_KMT2A_like; 1.
DR   CDD; cd15508; PHD3_KMT2A_like; 1.
DR   CDD; cd15489; PHD_SF; 1.
DR   CDD; cd04329; RNAP_II_Rpb7_N; 1.
DR   CDD; cd04462; S1_RNAPII_Rpb7; 1.
DR   CDD; cd19170; SET_KMT2A_2B; 1.
DR   Gene3D; 3.30.160.360; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.30.1490.120; RNA polymerase Rpb7-like, N-terminal domain; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR034732; EPHD.
DR   InterPro; IPR003889; FYrich_C.
DR   InterPro; IPR003888; FYrich_N.
DR   InterPro; IPR047219; KMT2A_2B_SET.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR036898; RNA_pol_Rpb7-like_N_sf.
DR   InterPro; IPR005576; Rpb7-like_N.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR45838:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX; 1.
DR   PANTHER; PTHR45838; HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER; 1.
DR   Pfam; PF05965; FYRC; 1.
DR   Pfam; PF05964; FYRN; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00575; S1; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF03876; SHS2_Rpb7-N; 1.
DR   Pfam; PF13771; zf-HC5HC2H; 1.
DR   SMART; SM00542; FYRC; 1.
DR   SMART; SM00249; PHD; 4.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR   SUPFAM; SSF88798; N-terminal, heterodimerisation domain of RBP7 (RpoE); 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51805; EPHD; 1.
DR   PROSITE; PS51543; FYRC; 1.
DR   PROSITE; PS51542; FYRN; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 3.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EEB10952.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEB10952.1};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   DOMAIN          563..663
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          920..973
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          970..1021
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1049..1110
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1484..1592
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51805"
FT   DOMAIN          3171..3289
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          3295..3311
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          803..826
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1296..1317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2011..2042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2898..2917
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2930..2951
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2012..2042
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2898..2912
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3311 AA;  374070 MW;  4FAE8C5D6519026D CRC64;
     MKISLEHEIL LHPRYFGPQL LETVKQKLYA EVEGTCTGKY GFVIAVTLID NIGAGLILPG
     QGFVVYPVKY RAIVFRPFKG EVLDAVVTQV NKVGMFAEIG PLSCFISHHS IPADMQFCPN
     FNPPCYKSKD EDVVIQADDE IRLKIVGTRV DASGIFAIGT LMDDYLGLVG LTSVVAKMAT
     DRSLADRGIV EIKMGRSKFP GKPTKIGNRK RVNLSSCSLP EDNDSSTAAK NIYLGLSMFN
     ETFGDNETIT PGPFYGFSSN EIDEAMAEAR LQQKEAEVAH KKQGIDINFW DSFQSELFSV
     SSFTKHKLLP DNNCEKESKT IVSFDGGGLP FDFPFSHDNS DNEPSRTLNV NVVENNKVHK
     INKKVRISSK LEKTSSKIKK LRAPRFKFNK NKLQCSPIAN RSLQSQAAKK LLNKAKMTNL
     LEINKNLPAD KKFILPSRST HSSRVIKPNK RFFEDNIIKK KYLNSQSCLN ATVNNKQNLL
     EESRKKFETR KLHWENKSSE NLNLSESSNS SSSKFILREA RLQLDKDKTQ TSVLEGPFSS
     PNLSSLCSNT QLKINLMQST PGNKECAVCG IVIFCKFVEK PKEFGIFCCE NCQKFIWKII
     KSLESKKDFK LQCLKGNGLC EIVNIMKAQH FNVIESSYST KCQACWLKLC LKNFKMPNKL
     KQNLLKVLPV NMQINLSLDY GPTSSDTSSS KFRFSAKNMK HFKWFNENNS QEIRAVNKNN
     IIDLPWSNIS ESNILNKKVL RKRTKNGENT VQSNIFLGQN EKIKSVNDKN RQSIVLKGPR
     VKHVCRSASV ALGQPLATFP TDLGSKKKKT NESSEDCNKC TTSPSPESNG VECQEVEFFS
     ENVVDSKEEG KEKKLNTFKE TTCNLKEVQV SRLNNGVKSK KKTNIKIENP VSMDFWESYD
     PDEICETGFC LIGSEDFSVR ALCFLCGSSG QEKLIHCASC CEPYHEFCID EAQLKLQNNT
     WKFDWVCPRC TVCFTCGKTS GQQLKCVKCD NSYHIECVDR VGGRLLHSPD RPWVCSICLR
     CKSCNGVDVS VFVGNLPLCR ACFVLRQKGN FCPLCQRCYN DDDYDSKMME CGQCKCWVHA
     KCEGLSDEKY QVLSFLPESV EYVCRMCCVM PPAPWWIAVE AELKSGYLGV LKALSKNRKA
     CTMLKWSPRK QCTCRPVEYT SRAFDLDVLN RTSKMLDVEL EEISNSEKEI NEKKKIHEEK
     EMIEKYQPAI LSERKTSIEV INHPTESLKL TLKIMKNCDT ETENITESTT KDKSVKDIFD
     DEKLQENSER VKNLIANQKF SDNSQSVNRK ISPFEYNKVN SSNSGNTLDS DAGNSAKDRS
     SIYDQNCFQL SSLETNKANG DISVNLLEGT RECVCFLDVE SYNSRSKPFS PNLMSIKKKV
     TTSEYSSLHQ FHQDMERMIA TSHSTELMDL YHQTIREIFP WFDPKFSKVQ NSSQKVSSIK
     SAESTPVKST PKKIIPEEEC KIPKYKLYDQ PLDYFYSDYT VQDTRICVMC KVVGDGLPGH
     TGRLLYCGQN EWVHCNCALW SGEVFEEIDG SLQNVHSAIS RSRSIKCPEC NLKGASIGCC
     ARSCQETYHF SCAKKLGCAF MDDKTMYCLA HLKDVNNKLV QNEKEFEIRR PVYVELDKRK
     MKTADSCQIR FVVGSLHVNN LGKFAGKLSD ETKSIIPDQF SCTRLFWSCF EPWRIVRYHF
     SVRLVEAENT QGVDTGINLT VDHSKDPELV ELKLKQLKYF QENNSFLEIN EKLVENQLGE
     KRKLVELKAK CDKIKISDSN SPKKDKKNQK VVRKILDQYD FKDDENCLSD NQNTADLLPP
     DVEEAIFKDL PHDILDGISM QDIFMDIKNY EYNSKENSEE LYEGDDNLFN SLNKIHKKNE
     NIQNESIWTE SIDCKLEVIG ETSLVSKSRN VKRNRTDDSL LLPSKKSTTL KTYQKSTNLN
     RNYKCENFNN KWKKHSKCHV TVNLLEPQER GNMLQELKFT DGLVSITTGA IGSMKDLKSR
     LEDNKRSIQE EGKENKFLAW QTRLQPRLLQ VDGGVDSSSS GSEAGESPQR MTEESVTSKL
     VDSSSQILDP LYSIKSSNVP EFQNFSTSEN SHHSNKSSVS FSKGNTDSNS FILPQVDGVE
     DCNSDVSDSE IQNCKKYSLK EIQNFNKVMV RKRDLINVFD LNYKIVQCDG GVDSECEEET
     FKNCNLSDGS VYPLVAKVEE EPVKCGKCRC TYRTKISYQR HLESCTSDFI LSSSEAEMSD
     EESPKRHFNN ISLKQKSDNI NALAIPAKTT NKEHSKKNIS YNSHLANDSL QISSHLNPIN
     FEKPEVKKEK VKKTYTRRKV PTATKKNSPV NNKQQVQQIL LQQQSAAAAP ALIVQDVTGS
     NLMSTAYIDS TPTLGYLAGI ESQHFLNKTQ LISTPGGVIS GNFHVPSPSE SQVLGGLCLN
     TQNVQNNFPG FIIQQQPNIQ GPVLSSQNSP VILSNEQLMV GSTDSYNVFQ DPRTGGMFLT
     SRNAPVFYNM ETIVSNTVMQ TNQFVSNVLG TTFSQTSTQI FQASEMEQIV NVPSNYILVN
     SNHAGANRLF PSNDLLCVQT QPTFIQNQTP IQLGSSNQTV QPSQIFNPSI PTAQILNFDP
     KTLPIQNNSF RCLQPVCPPI ILGKVSNGLN NNVVNSTVPQ VLQKTPASTP TIVNPVVTSK
     SVPTIKPQQL NGFSSSQMTK LPVKIPEKPA IPLKSNPQSQ IQSRSRALVD YINNFRSEAN
     ETLLKSAQVQ NKTKNNICDK SSSQSYNLNS SNKSINLNTC ISTQQKVMQN QNNFHKSSSL
     STELVNPSCK TEVKSTNNLK IPKSASSELL VTKAEIQSPA SLKSEKIILP AKPLAANEPI
     PSVKNFKIKN EKITSCTKTE ESCPRRESSL ISTSEETEKS PCAGVKIFQN LPPSNFEMQE
     KEDGSTVPDS KNIEISMHED SRPVKDEYPK QDNNTNHVLP LQENCQKINI SPKNNNVKSS
     PKGHSKDGEN LFLKQEENYK IKRKINFLDQ NSFDSKSLGI NDKFESPPDK DASEVVADEN
     ISFSKKSIEE KGPKLIFDVI SDDGFKKSSS SMAELWANIC DSVQEMRAML KIPSLPLTKK
     DYEILGMQNH GLQHCLEQLK GVENCVNYKF KYFTRDDSRR DSEDEVKENP SGCARTEKFT
     NRKEYDMFAW LASKHRKLPK LTESAEETLC SIRRANNLPM AMKYRNLKET SKLYVGVYRS
     QIHGRGLFCL REIEAGEMVI EYAGEVIRAN LSDKREKYYT EKGIGCYMFR IDDHFVVDAT
     MKGNAARFIN HSCEPNCYSR VVDILGKKHI VIFALRKINI MEELTYDYKF PFEDEKISCH
     CLSKKCKKYL N
//