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E0VC46

- E0VC46_PEDHC

UniProt

E0VC46 - E0VC46_PEDHC

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Protein
Submitted name:

Mixed-lineage leukemia protein, mll, putative

Gene

Phum_PHUM079870

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. DNA-directed RNA polymerase activity Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. RNA binding Source: InterPro
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: InterPro
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Mixed-lineage leukemia protein, mll, putativeImported (EC:2.1.1.43Imported)
Gene namesi
ORF Names:Phum_PHUM079870Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

InParanoidiE0VC46.
KOiK09186.
OMAiARCEPYS.
OrthoDBiEOG75XGJZ.
PhylomeDBiE0VC46.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.1490.120. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR012340. NA-bd_OB-fold.
IPR003616. Post-SET_dom.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR005576. RNA_pol_Rpb7_N.
IPR022967. S1_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00575. S1. 1 hit.
PF00856. SET. 1 hit.
PF03876. SHS2_Rpb7-N. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00316. S1. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57903. SSF57903. 3 hits.
SSF88798. SSF88798. 1 hit.
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0VC46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISLEHEIL LHPRYFGPQL LETVKQKLYA EVEGTCTGKY GFVIAVTLID
60 70 80 90 100
NIGAGLILPG QGFVVYPVKY RAIVFRPFKG EVLDAVVTQV NKVGMFAEIG
110 120 130 140 150
PLSCFISHHS IPADMQFCPN FNPPCYKSKD EDVVIQADDE IRLKIVGTRV
160 170 180 190 200
DASGIFAIGT LMDDYLGLVG LTSVVAKMAT DRSLADRGIV EIKMGRSKFP
210 220 230 240 250
GKPTKIGNRK RVNLSSCSLP EDNDSSTAAK NIYLGLSMFN ETFGDNETIT
260 270 280 290 300
PGPFYGFSSN EIDEAMAEAR LQQKEAEVAH KKQGIDINFW DSFQSELFSV
310 320 330 340 350
SSFTKHKLLP DNNCEKESKT IVSFDGGGLP FDFPFSHDNS DNEPSRTLNV
360 370 380 390 400
NVVENNKVHK INKKVRISSK LEKTSSKIKK LRAPRFKFNK NKLQCSPIAN
410 420 430 440 450
RSLQSQAAKK LLNKAKMTNL LEINKNLPAD KKFILPSRST HSSRVIKPNK
460 470 480 490 500
RFFEDNIIKK KYLNSQSCLN ATVNNKQNLL EESRKKFETR KLHWENKSSE
510 520 530 540 550
NLNLSESSNS SSSKFILREA RLQLDKDKTQ TSVLEGPFSS PNLSSLCSNT
560 570 580 590 600
QLKINLMQST PGNKECAVCG IVIFCKFVEK PKEFGIFCCE NCQKFIWKII
610 620 630 640 650
KSLESKKDFK LQCLKGNGLC EIVNIMKAQH FNVIESSYST KCQACWLKLC
660 670 680 690 700
LKNFKMPNKL KQNLLKVLPV NMQINLSLDY GPTSSDTSSS KFRFSAKNMK
710 720 730 740 750
HFKWFNENNS QEIRAVNKNN IIDLPWSNIS ESNILNKKVL RKRTKNGENT
760 770 780 790 800
VQSNIFLGQN EKIKSVNDKN RQSIVLKGPR VKHVCRSASV ALGQPLATFP
810 820 830 840 850
TDLGSKKKKT NESSEDCNKC TTSPSPESNG VECQEVEFFS ENVVDSKEEG
860 870 880 890 900
KEKKLNTFKE TTCNLKEVQV SRLNNGVKSK KKTNIKIENP VSMDFWESYD
910 920 930 940 950
PDEICETGFC LIGSEDFSVR ALCFLCGSSG QEKLIHCASC CEPYHEFCID
960 970 980 990 1000
EAQLKLQNNT WKFDWVCPRC TVCFTCGKTS GQQLKCVKCD NSYHIECVDR
1010 1020 1030 1040 1050
VGGRLLHSPD RPWVCSICLR CKSCNGVDVS VFVGNLPLCR ACFVLRQKGN
1060 1070 1080 1090 1100
FCPLCQRCYN DDDYDSKMME CGQCKCWVHA KCEGLSDEKY QVLSFLPESV
1110 1120 1130 1140 1150
EYVCRMCCVM PPAPWWIAVE AELKSGYLGV LKALSKNRKA CTMLKWSPRK
1160 1170 1180 1190 1200
QCTCRPVEYT SRAFDLDVLN RTSKMLDVEL EEISNSEKEI NEKKKIHEEK
1210 1220 1230 1240 1250
EMIEKYQPAI LSERKTSIEV INHPTESLKL TLKIMKNCDT ETENITESTT
1260 1270 1280 1290 1300
KDKSVKDIFD DEKLQENSER VKNLIANQKF SDNSQSVNRK ISPFEYNKVN
1310 1320 1330 1340 1350
SSNSGNTLDS DAGNSAKDRS SIYDQNCFQL SSLETNKANG DISVNLLEGT
1360 1370 1380 1390 1400
RECVCFLDVE SYNSRSKPFS PNLMSIKKKV TTSEYSSLHQ FHQDMERMIA
1410 1420 1430 1440 1450
TSHSTELMDL YHQTIREIFP WFDPKFSKVQ NSSQKVSSIK SAESTPVKST
1460 1470 1480 1490 1500
PKKIIPEEEC KIPKYKLYDQ PLDYFYSDYT VQDTRICVMC KVVGDGLPGH
1510 1520 1530 1540 1550
TGRLLYCGQN EWVHCNCALW SGEVFEEIDG SLQNVHSAIS RSRSIKCPEC
1560 1570 1580 1590 1600
NLKGASIGCC ARSCQETYHF SCAKKLGCAF MDDKTMYCLA HLKDVNNKLV
1610 1620 1630 1640 1650
QNEKEFEIRR PVYVELDKRK MKTADSCQIR FVVGSLHVNN LGKFAGKLSD
1660 1670 1680 1690 1700
ETKSIIPDQF SCTRLFWSCF EPWRIVRYHF SVRLVEAENT QGVDTGINLT
1710 1720 1730 1740 1750
VDHSKDPELV ELKLKQLKYF QENNSFLEIN EKLVENQLGE KRKLVELKAK
1760 1770 1780 1790 1800
CDKIKISDSN SPKKDKKNQK VVRKILDQYD FKDDENCLSD NQNTADLLPP
1810 1820 1830 1840 1850
DVEEAIFKDL PHDILDGISM QDIFMDIKNY EYNSKENSEE LYEGDDNLFN
1860 1870 1880 1890 1900
SLNKIHKKNE NIQNESIWTE SIDCKLEVIG ETSLVSKSRN VKRNRTDDSL
1910 1920 1930 1940 1950
LLPSKKSTTL KTYQKSTNLN RNYKCENFNN KWKKHSKCHV TVNLLEPQER
1960 1970 1980 1990 2000
GNMLQELKFT DGLVSITTGA IGSMKDLKSR LEDNKRSIQE EGKENKFLAW
2010 2020 2030 2040 2050
QTRLQPRLLQ VDGGVDSSSS GSEAGESPQR MTEESVTSKL VDSSSQILDP
2060 2070 2080 2090 2100
LYSIKSSNVP EFQNFSTSEN SHHSNKSSVS FSKGNTDSNS FILPQVDGVE
2110 2120 2130 2140 2150
DCNSDVSDSE IQNCKKYSLK EIQNFNKVMV RKRDLINVFD LNYKIVQCDG
2160 2170 2180 2190 2200
GVDSECEEET FKNCNLSDGS VYPLVAKVEE EPVKCGKCRC TYRTKISYQR
2210 2220 2230 2240 2250
HLESCTSDFI LSSSEAEMSD EESPKRHFNN ISLKQKSDNI NALAIPAKTT
2260 2270 2280 2290 2300
NKEHSKKNIS YNSHLANDSL QISSHLNPIN FEKPEVKKEK VKKTYTRRKV
2310 2320 2330 2340 2350
PTATKKNSPV NNKQQVQQIL LQQQSAAAAP ALIVQDVTGS NLMSTAYIDS
2360 2370 2380 2390 2400
TPTLGYLAGI ESQHFLNKTQ LISTPGGVIS GNFHVPSPSE SQVLGGLCLN
2410 2420 2430 2440 2450
TQNVQNNFPG FIIQQQPNIQ GPVLSSQNSP VILSNEQLMV GSTDSYNVFQ
2460 2470 2480 2490 2500
DPRTGGMFLT SRNAPVFYNM ETIVSNTVMQ TNQFVSNVLG TTFSQTSTQI
2510 2520 2530 2540 2550
FQASEMEQIV NVPSNYILVN SNHAGANRLF PSNDLLCVQT QPTFIQNQTP
2560 2570 2580 2590 2600
IQLGSSNQTV QPSQIFNPSI PTAQILNFDP KTLPIQNNSF RCLQPVCPPI
2610 2620 2630 2640 2650
ILGKVSNGLN NNVVNSTVPQ VLQKTPASTP TIVNPVVTSK SVPTIKPQQL
2660 2670 2680 2690 2700
NGFSSSQMTK LPVKIPEKPA IPLKSNPQSQ IQSRSRALVD YINNFRSEAN
2710 2720 2730 2740 2750
ETLLKSAQVQ NKTKNNICDK SSSQSYNLNS SNKSINLNTC ISTQQKVMQN
2760 2770 2780 2790 2800
QNNFHKSSSL STELVNPSCK TEVKSTNNLK IPKSASSELL VTKAEIQSPA
2810 2820 2830 2840 2850
SLKSEKIILP AKPLAANEPI PSVKNFKIKN EKITSCTKTE ESCPRRESSL
2860 2870 2880 2890 2900
ISTSEETEKS PCAGVKIFQN LPPSNFEMQE KEDGSTVPDS KNIEISMHED
2910 2920 2930 2940 2950
SRPVKDEYPK QDNNTNHVLP LQENCQKINI SPKNNNVKSS PKGHSKDGEN
2960 2970 2980 2990 3000
LFLKQEENYK IKRKINFLDQ NSFDSKSLGI NDKFESPPDK DASEVVADEN
3010 3020 3030 3040 3050
ISFSKKSIEE KGPKLIFDVI SDDGFKKSSS SMAELWANIC DSVQEMRAML
3060 3070 3080 3090 3100
KIPSLPLTKK DYEILGMQNH GLQHCLEQLK GVENCVNYKF KYFTRDDSRR
3110 3120 3130 3140 3150
DSEDEVKENP SGCARTEKFT NRKEYDMFAW LASKHRKLPK LTESAEETLC
3160 3170 3180 3190 3200
SIRRANNLPM AMKYRNLKET SKLYVGVYRS QIHGRGLFCL REIEAGEMVI
3210 3220 3230 3240 3250
EYAGEVIRAN LSDKREKYYT EKGIGCYMFR IDDHFVVDAT MKGNAARFIN
3260 3270 3280 3290 3300
HSCEPNCYSR VVDILGKKHI VIFALRKINI MEELTYDYKF PFEDEKISCH
3310
CLSKKCKKYL N
Length:3,311
Mass (Da):374,070
Last modified:November 2, 2010 - v1
Checksum:i4FAE8C5D6519026D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235047 Genomic DNA. Translation: EEB10952.1.
RefSeqiXP_002423690.1. XM_002423645.1.

Genome annotation databases

EnsemblMetazoaiPHUM079870-RA; PHUM079870-PA; PHUM079870.
GeneIDi8231358.
KEGGiphu:Phum_PHUM079870.
VectorBaseiPHUM079870. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235047 Genomic DNA. Translation: EEB10952.1 .
RefSeqi XP_002423690.1. XM_002423645.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai PHUM079870-RA ; PHUM079870-PA ; PHUM079870 .
GeneIDi 8231358.
KEGGi phu:Phum_PHUM079870.
VectorBasei PHUM079870. Pediculus humanus.

Organism-specific databases

CTDi 8231358.

Phylogenomic databases

InParanoidi E0VC46.
KOi K09186.
OMAi ARCEPYS.
OrthoDBi EOG75XGJZ.
PhylomeDBi E0VC46.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.1490.120. 1 hit.
3.30.40.10. 2 hits.
InterProi IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR012340. NA-bd_OB-fold.
IPR003616. Post-SET_dom.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR005576. RNA_pol_Rpb7_N.
IPR022967. S1_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00575. S1. 1 hit.
PF00856. SET. 1 hit.
PF03876. SHS2_Rpb7-N. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00316. S1. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF57903. SSF57903. 3 hits.
SSF88798. SSF88798. 1 hit.
PROSITEi PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0VC46_PEDHC
AccessioniPrimary (citable) accession number: E0VC46
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3