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E0VC46

- E0VC46_PEDHC

UniProt

E0VC46 - E0VC46_PEDHC

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Protein
Submitted name:

Mixed-lineage leukemia protein, mll, putative

Gene
Phum_PHUM079870
Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotations

GO - Molecular functioni

  1. DNA-directed RNA polymerase activity Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. RNA binding Source: InterPro
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: InterPro
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotations, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Mixed-lineage leukemia protein, mll, putativeImported (EC:2.1.1.43Imported)
Gene namesi
ORF Names:Phum_PHUM079870Imported
OrganismiPediculus humanus subsp. corporis (Body louse)
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

KOiK09186.
OMAiARCEPYS.
OrthoDBiEOG75XGJZ.
PhylomeDBiE0VC46.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.1490.120. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR012340. NA-bd_OB-fold.
IPR003616. Post-SET_dom.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. RNA-binding_domain_S1.
IPR005576. RNA_pol_Rpb7_N.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00575. S1. 1 hit.
PF00856. SET. 1 hit.
PF03876. SHS2_Rpb7-N. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00316. S1. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57903. SSF57903. 3 hits.
SSF88798. SSF88798. 1 hit.
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0VC46-1 [UniParc]FASTAAdd to Basket

« Hide

MKISLEHEIL LHPRYFGPQL LETVKQKLYA EVEGTCTGKY GFVIAVTLID     50
NIGAGLILPG QGFVVYPVKY RAIVFRPFKG EVLDAVVTQV NKVGMFAEIG 100
PLSCFISHHS IPADMQFCPN FNPPCYKSKD EDVVIQADDE IRLKIVGTRV 150
DASGIFAIGT LMDDYLGLVG LTSVVAKMAT DRSLADRGIV EIKMGRSKFP 200
GKPTKIGNRK RVNLSSCSLP EDNDSSTAAK NIYLGLSMFN ETFGDNETIT 250
PGPFYGFSSN EIDEAMAEAR LQQKEAEVAH KKQGIDINFW DSFQSELFSV 300
SSFTKHKLLP DNNCEKESKT IVSFDGGGLP FDFPFSHDNS DNEPSRTLNV 350
NVVENNKVHK INKKVRISSK LEKTSSKIKK LRAPRFKFNK NKLQCSPIAN 400
RSLQSQAAKK LLNKAKMTNL LEINKNLPAD KKFILPSRST HSSRVIKPNK 450
RFFEDNIIKK KYLNSQSCLN ATVNNKQNLL EESRKKFETR KLHWENKSSE 500
NLNLSESSNS SSSKFILREA RLQLDKDKTQ TSVLEGPFSS PNLSSLCSNT 550
QLKINLMQST PGNKECAVCG IVIFCKFVEK PKEFGIFCCE NCQKFIWKII 600
KSLESKKDFK LQCLKGNGLC EIVNIMKAQH FNVIESSYST KCQACWLKLC 650
LKNFKMPNKL KQNLLKVLPV NMQINLSLDY GPTSSDTSSS KFRFSAKNMK 700
HFKWFNENNS QEIRAVNKNN IIDLPWSNIS ESNILNKKVL RKRTKNGENT 750
VQSNIFLGQN EKIKSVNDKN RQSIVLKGPR VKHVCRSASV ALGQPLATFP 800
TDLGSKKKKT NESSEDCNKC TTSPSPESNG VECQEVEFFS ENVVDSKEEG 850
KEKKLNTFKE TTCNLKEVQV SRLNNGVKSK KKTNIKIENP VSMDFWESYD 900
PDEICETGFC LIGSEDFSVR ALCFLCGSSG QEKLIHCASC CEPYHEFCID 950
EAQLKLQNNT WKFDWVCPRC TVCFTCGKTS GQQLKCVKCD NSYHIECVDR 1000
VGGRLLHSPD RPWVCSICLR CKSCNGVDVS VFVGNLPLCR ACFVLRQKGN 1050
FCPLCQRCYN DDDYDSKMME CGQCKCWVHA KCEGLSDEKY QVLSFLPESV 1100
EYVCRMCCVM PPAPWWIAVE AELKSGYLGV LKALSKNRKA CTMLKWSPRK 1150
QCTCRPVEYT SRAFDLDVLN RTSKMLDVEL EEISNSEKEI NEKKKIHEEK 1200
EMIEKYQPAI LSERKTSIEV INHPTESLKL TLKIMKNCDT ETENITESTT 1250
KDKSVKDIFD DEKLQENSER VKNLIANQKF SDNSQSVNRK ISPFEYNKVN 1300
SSNSGNTLDS DAGNSAKDRS SIYDQNCFQL SSLETNKANG DISVNLLEGT 1350
RECVCFLDVE SYNSRSKPFS PNLMSIKKKV TTSEYSSLHQ FHQDMERMIA 1400
TSHSTELMDL YHQTIREIFP WFDPKFSKVQ NSSQKVSSIK SAESTPVKST 1450
PKKIIPEEEC KIPKYKLYDQ PLDYFYSDYT VQDTRICVMC KVVGDGLPGH 1500
TGRLLYCGQN EWVHCNCALW SGEVFEEIDG SLQNVHSAIS RSRSIKCPEC 1550
NLKGASIGCC ARSCQETYHF SCAKKLGCAF MDDKTMYCLA HLKDVNNKLV 1600
QNEKEFEIRR PVYVELDKRK MKTADSCQIR FVVGSLHVNN LGKFAGKLSD 1650
ETKSIIPDQF SCTRLFWSCF EPWRIVRYHF SVRLVEAENT QGVDTGINLT 1700
VDHSKDPELV ELKLKQLKYF QENNSFLEIN EKLVENQLGE KRKLVELKAK 1750
CDKIKISDSN SPKKDKKNQK VVRKILDQYD FKDDENCLSD NQNTADLLPP 1800
DVEEAIFKDL PHDILDGISM QDIFMDIKNY EYNSKENSEE LYEGDDNLFN 1850
SLNKIHKKNE NIQNESIWTE SIDCKLEVIG ETSLVSKSRN VKRNRTDDSL 1900
LLPSKKSTTL KTYQKSTNLN RNYKCENFNN KWKKHSKCHV TVNLLEPQER 1950
GNMLQELKFT DGLVSITTGA IGSMKDLKSR LEDNKRSIQE EGKENKFLAW 2000
QTRLQPRLLQ VDGGVDSSSS GSEAGESPQR MTEESVTSKL VDSSSQILDP 2050
LYSIKSSNVP EFQNFSTSEN SHHSNKSSVS FSKGNTDSNS FILPQVDGVE 2100
DCNSDVSDSE IQNCKKYSLK EIQNFNKVMV RKRDLINVFD LNYKIVQCDG 2150
GVDSECEEET FKNCNLSDGS VYPLVAKVEE EPVKCGKCRC TYRTKISYQR 2200
HLESCTSDFI LSSSEAEMSD EESPKRHFNN ISLKQKSDNI NALAIPAKTT 2250
NKEHSKKNIS YNSHLANDSL QISSHLNPIN FEKPEVKKEK VKKTYTRRKV 2300
PTATKKNSPV NNKQQVQQIL LQQQSAAAAP ALIVQDVTGS NLMSTAYIDS 2350
TPTLGYLAGI ESQHFLNKTQ LISTPGGVIS GNFHVPSPSE SQVLGGLCLN 2400
TQNVQNNFPG FIIQQQPNIQ GPVLSSQNSP VILSNEQLMV GSTDSYNVFQ 2450
DPRTGGMFLT SRNAPVFYNM ETIVSNTVMQ TNQFVSNVLG TTFSQTSTQI 2500
FQASEMEQIV NVPSNYILVN SNHAGANRLF PSNDLLCVQT QPTFIQNQTP 2550
IQLGSSNQTV QPSQIFNPSI PTAQILNFDP KTLPIQNNSF RCLQPVCPPI 2600
ILGKVSNGLN NNVVNSTVPQ VLQKTPASTP TIVNPVVTSK SVPTIKPQQL 2650
NGFSSSQMTK LPVKIPEKPA IPLKSNPQSQ IQSRSRALVD YINNFRSEAN 2700
ETLLKSAQVQ NKTKNNICDK SSSQSYNLNS SNKSINLNTC ISTQQKVMQN 2750
QNNFHKSSSL STELVNPSCK TEVKSTNNLK IPKSASSELL VTKAEIQSPA 2800
SLKSEKIILP AKPLAANEPI PSVKNFKIKN EKITSCTKTE ESCPRRESSL 2850
ISTSEETEKS PCAGVKIFQN LPPSNFEMQE KEDGSTVPDS KNIEISMHED 2900
SRPVKDEYPK QDNNTNHVLP LQENCQKINI SPKNNNVKSS PKGHSKDGEN 2950
LFLKQEENYK IKRKINFLDQ NSFDSKSLGI NDKFESPPDK DASEVVADEN 3000
ISFSKKSIEE KGPKLIFDVI SDDGFKKSSS SMAELWANIC DSVQEMRAML 3050
KIPSLPLTKK DYEILGMQNH GLQHCLEQLK GVENCVNYKF KYFTRDDSRR 3100
DSEDEVKENP SGCARTEKFT NRKEYDMFAW LASKHRKLPK LTESAEETLC 3150
SIRRANNLPM AMKYRNLKET SKLYVGVYRS QIHGRGLFCL REIEAGEMVI 3200
EYAGEVIRAN LSDKREKYYT EKGIGCYMFR IDDHFVVDAT MKGNAARFIN 3250
HSCEPNCYSR VVDILGKKHI VIFALRKINI MEELTYDYKF PFEDEKISCH 3300
CLSKKCKKYL N 3311
Length:3,311
Mass (Da):374,070
Last modified:November 2, 2010 - v1
Checksum:i4FAE8C5D6519026D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS235047 Genomic DNA. Translation: EEB10952.1.
RefSeqiXP_002423690.1. XM_002423645.1.

Genome annotation databases

GeneIDi8231358.
KEGGiphu:Phum_PHUM079870.
VectorBaseiPHUM079870. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS235047 Genomic DNA. Translation: EEB10952.1 .
RefSeqi XP_002423690.1. XM_002423645.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8231358.
KEGGi phu:Phum_PHUM079870.
VectorBasei PHUM079870. Pediculus humanus.

Organism-specific databases

CTDi 8231358.

Phylogenomic databases

KOi K09186.
OMAi ARCEPYS.
OrthoDBi EOG75XGJZ.
PhylomeDBi E0VC46.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.1490.120. 1 hit.
3.30.40.10. 2 hits.
InterProi IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR012340. NA-bd_OB-fold.
IPR003616. Post-SET_dom.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. RNA-binding_domain_S1.
IPR005576. RNA_pol_Rpb7_N.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00575. S1. 1 hit.
PF00856. SET. 1 hit.
PF03876. SHS2_Rpb7-N. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00316. S1. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF57903. SSF57903. 3 hits.
SSF88798. SSF88798. 1 hit.
PROSITEi PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDA.

Entry informationi

Entry nameiE0VC46_PEDHC
AccessioniPrimary (citable) accession number: E0VC46
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3