E0VC46 (E0VC46_PEDHC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Mixed-lineage leukemia protein, mll, putative EMBL EEB10952.1
EC=2.1.1.43 EMBL EEB10952.1

Gene names

ORF Names:

Phum_PHUM079870 EMBL EEB10952.1

Organism

Pediculus humanus subsp. corporis (Body louse) [Reference proteome]

Taxonomic identifier

121224 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Paraneoptera › Phthiraptera › Anoplura › Pediculidae › Pediculus › Pediculus humanus

Protein attributes

Sequence length	3311 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 SAAS SAAS001214 Contains 1 post-SET domain. RuleBase RU004541 SAAS SAAS001214

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Domain	Zinc-finger SAAS SAAS001965
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase RuleBase RU004541 SAAS SAAS001214 EMBL EEB10952.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: InterPro RNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E0VC46 [UniParc]. Last modified November 2, 2010. Version 1. Checksum: 4FAE8C5D6519026D	FASTA	3,311	374,070
	10 20 30 40 50 60 MKISLEHEIL LHPRYFGPQL LETVKQKLYA EVEGTCTGKY GFVIAVTLID NIGAGLILPG 70 80 90 100 110 120 QGFVVYPVKY RAIVFRPFKG EVLDAVVTQV NKVGMFAEIG PLSCFISHHS IPADMQFCPN 130 140 150 160 170 180 FNPPCYKSKD EDVVIQADDE IRLKIVGTRV DASGIFAIGT LMDDYLGLVG LTSVVAKMAT 190 200 210 220 230 240 DRSLADRGIV EIKMGRSKFP GKPTKIGNRK RVNLSSCSLP EDNDSSTAAK NIYLGLSMFN 250 260 270 280 290 300 ETFGDNETIT PGPFYGFSSN EIDEAMAEAR LQQKEAEVAH KKQGIDINFW DSFQSELFSV 310 320 330 340 350 360 SSFTKHKLLP DNNCEKESKT IVSFDGGGLP FDFPFSHDNS DNEPSRTLNV NVVENNKVHK 370 380 390 400 410 420 INKKVRISSK LEKTSSKIKK LRAPRFKFNK NKLQCSPIAN RSLQSQAAKK LLNKAKMTNL 430 440 450 460 470 480 LEINKNLPAD KKFILPSRST HSSRVIKPNK RFFEDNIIKK KYLNSQSCLN ATVNNKQNLL 490 500 510 520 530 540 EESRKKFETR KLHWENKSSE NLNLSESSNS SSSKFILREA RLQLDKDKTQ TSVLEGPFSS 550 560 570 580 590 600 PNLSSLCSNT QLKINLMQST PGNKECAVCG IVIFCKFVEK PKEFGIFCCE NCQKFIWKII 610 620 630 640 650 660 KSLESKKDFK LQCLKGNGLC EIVNIMKAQH FNVIESSYST KCQACWLKLC LKNFKMPNKL 670 680 690 700 710 720 KQNLLKVLPV NMQINLSLDY GPTSSDTSSS KFRFSAKNMK HFKWFNENNS QEIRAVNKNN 730 740 750 760 770 780 IIDLPWSNIS ESNILNKKVL RKRTKNGENT VQSNIFLGQN EKIKSVNDKN RQSIVLKGPR 790 800 810 820 830 840 VKHVCRSASV ALGQPLATFP TDLGSKKKKT NESSEDCNKC TTSPSPESNG VECQEVEFFS 850 860 870 880 890 900 ENVVDSKEEG KEKKLNTFKE TTCNLKEVQV SRLNNGVKSK KKTNIKIENP VSMDFWESYD 910 920 930 940 950 960 PDEICETGFC LIGSEDFSVR ALCFLCGSSG QEKLIHCASC CEPYHEFCID EAQLKLQNNT 970 980 990 1000 1010 1020 WKFDWVCPRC TVCFTCGKTS GQQLKCVKCD NSYHIECVDR VGGRLLHSPD RPWVCSICLR 1030 1040 1050 1060 1070 1080 CKSCNGVDVS VFVGNLPLCR ACFVLRQKGN FCPLCQRCYN DDDYDSKMME CGQCKCWVHA 1090 1100 1110 1120 1130 1140 KCEGLSDEKY QVLSFLPESV EYVCRMCCVM PPAPWWIAVE AELKSGYLGV LKALSKNRKA 1150 1160 1170 1180 1190 1200 CTMLKWSPRK QCTCRPVEYT SRAFDLDVLN RTSKMLDVEL EEISNSEKEI NEKKKIHEEK 1210 1220 1230 1240 1250 1260 EMIEKYQPAI LSERKTSIEV INHPTESLKL TLKIMKNCDT ETENITESTT KDKSVKDIFD 1270 1280 1290 1300 1310 1320 DEKLQENSER VKNLIANQKF SDNSQSVNRK ISPFEYNKVN SSNSGNTLDS DAGNSAKDRS 1330 1340 1350 1360 1370 1380 SIYDQNCFQL SSLETNKANG DISVNLLEGT RECVCFLDVE SYNSRSKPFS PNLMSIKKKV 1390 1400 1410 1420 1430 1440 TTSEYSSLHQ FHQDMERMIA TSHSTELMDL YHQTIREIFP WFDPKFSKVQ NSSQKVSSIK 1450 1460 1470 1480 1490 1500 SAESTPVKST PKKIIPEEEC KIPKYKLYDQ PLDYFYSDYT VQDTRICVMC KVVGDGLPGH 1510 1520 1530 1540 1550 1560 TGRLLYCGQN EWVHCNCALW SGEVFEEIDG SLQNVHSAIS RSRSIKCPEC NLKGASIGCC 1570 1580 1590 1600 1610 1620 ARSCQETYHF SCAKKLGCAF MDDKTMYCLA HLKDVNNKLV QNEKEFEIRR PVYVELDKRK 1630 1640 1650 1660 1670 1680 MKTADSCQIR FVVGSLHVNN LGKFAGKLSD ETKSIIPDQF SCTRLFWSCF EPWRIVRYHF 1690 1700 1710 1720 1730 1740 SVRLVEAENT QGVDTGINLT VDHSKDPELV ELKLKQLKYF QENNSFLEIN EKLVENQLGE 1750 1760 1770 1780 1790 1800 KRKLVELKAK CDKIKISDSN SPKKDKKNQK VVRKILDQYD FKDDENCLSD NQNTADLLPP 1810 1820 1830 1840 1850 1860 DVEEAIFKDL PHDILDGISM QDIFMDIKNY EYNSKENSEE LYEGDDNLFN SLNKIHKKNE 1870 1880 1890 1900 1910 1920 NIQNESIWTE SIDCKLEVIG ETSLVSKSRN VKRNRTDDSL LLPSKKSTTL KTYQKSTNLN 1930 1940 1950 1960 1970 1980 RNYKCENFNN KWKKHSKCHV TVNLLEPQER GNMLQELKFT DGLVSITTGA IGSMKDLKSR 1990 2000 2010 2020 2030 2040 LEDNKRSIQE EGKENKFLAW QTRLQPRLLQ VDGGVDSSSS GSEAGESPQR MTEESVTSKL 2050 2060 2070 2080 2090 2100 VDSSSQILDP LYSIKSSNVP EFQNFSTSEN SHHSNKSSVS FSKGNTDSNS FILPQVDGVE 2110 2120 2130 2140 2150 2160 DCNSDVSDSE IQNCKKYSLK EIQNFNKVMV RKRDLINVFD LNYKIVQCDG GVDSECEEET 2170 2180 2190 2200 2210 2220 FKNCNLSDGS VYPLVAKVEE EPVKCGKCRC TYRTKISYQR HLESCTSDFI LSSSEAEMSD 2230 2240 2250 2260 2270 2280 EESPKRHFNN ISLKQKSDNI NALAIPAKTT NKEHSKKNIS YNSHLANDSL QISSHLNPIN 2290 2300 2310 2320 2330 2340 FEKPEVKKEK VKKTYTRRKV PTATKKNSPV NNKQQVQQIL LQQQSAAAAP ALIVQDVTGS 2350 2360 2370 2380 2390 2400 NLMSTAYIDS TPTLGYLAGI ESQHFLNKTQ LISTPGGVIS GNFHVPSPSE SQVLGGLCLN 2410 2420 2430 2440 2450 2460 TQNVQNNFPG FIIQQQPNIQ GPVLSSQNSP VILSNEQLMV GSTDSYNVFQ DPRTGGMFLT 2470 2480 2490 2500 2510 2520 SRNAPVFYNM ETIVSNTVMQ TNQFVSNVLG TTFSQTSTQI FQASEMEQIV NVPSNYILVN 2530 2540 2550 2560 2570 2580 SNHAGANRLF PSNDLLCVQT QPTFIQNQTP IQLGSSNQTV QPSQIFNPSI PTAQILNFDP 2590 2600 2610 2620 2630 2640 KTLPIQNNSF RCLQPVCPPI ILGKVSNGLN NNVVNSTVPQ VLQKTPASTP TIVNPVVTSK 2650 2660 2670 2680 2690 2700 SVPTIKPQQL NGFSSSQMTK LPVKIPEKPA IPLKSNPQSQ IQSRSRALVD YINNFRSEAN 2710 2720 2730 2740 2750 2760 ETLLKSAQVQ NKTKNNICDK SSSQSYNLNS SNKSINLNTC ISTQQKVMQN QNNFHKSSSL 2770 2780 2790 2800 2810 2820 STELVNPSCK TEVKSTNNLK IPKSASSELL VTKAEIQSPA SLKSEKIILP AKPLAANEPI 2830 2840 2850 2860 2870 2880 PSVKNFKIKN EKITSCTKTE ESCPRRESSL ISTSEETEKS PCAGVKIFQN LPPSNFEMQE 2890 2900 2910 2920 2930 2940 KEDGSTVPDS KNIEISMHED SRPVKDEYPK QDNNTNHVLP LQENCQKINI SPKNNNVKSS 2950 2960 2970 2980 2990 3000 PKGHSKDGEN LFLKQEENYK IKRKINFLDQ NSFDSKSLGI NDKFESPPDK DASEVVADEN 3010 3020 3030 3040 3050 3060 ISFSKKSIEE KGPKLIFDVI SDDGFKKSSS SMAELWANIC DSVQEMRAML KIPSLPLTKK 3070 3080 3090 3100 3110 3120 DYEILGMQNH GLQHCLEQLK GVENCVNYKF KYFTRDDSRR DSEDEVKENP SGCARTEKFT 3130 3140 3150 3160 3170 3180 NRKEYDMFAW LASKHRKLPK LTESAEETLC SIRRANNLPM AMKYRNLKET SKLYVGVYRS 3190 3200 3210 3220 3230 3240 QIHGRGLFCL REIEAGEMVI EYAGEVIRAN LSDKREKYYT EKGIGCYMFR IDDHFVVDAT 3250 3260 3270 3280 3290 3300 MKGNAARFIN HSCEPNCYSR VVDILGKKHI VIFALRKINI MEELTYDYKF PFEDEKISCH 3310 CLSKKCKKYL N

References

[1]

"Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle." Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M. , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R. Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS235047 Genomic DNA. Translation: EEB10952.1.
RefSeq	XP_002423690.1. XM_002423645.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8231358.
KEGG	phu:Phum_PHUM079870.
VectorBase	PHUM079870. Pediculus humanus.
Organism-specific databases
CTD	8231358.
Phylogenomic databases
KO	K09186.
OMA	RQPRLQF.
Family and domain databases
Gene3D	2.40.50.140. 1 hit. 3.30.1490.120. 1 hit. 3.30.40.10. 2 hits.
InterPro	IPR003889. FYrich_C. IPR003888. FYrich_N. IPR015722. Histone-lysine_MeTfrase. IPR012340. NA-bd_OB-fold. IPR003616. Post-SET_dom. IPR003029. Rbsml_prot_S1_RNA-bd_dom. IPR022967. RNA-binding_domain_S1. IPR005576. RNA_pol_Rpb7_N. IPR001214. SET_dom. IPR011011. Znf_FYVE_PHD. IPR001628. Znf_hrmn_rcpt. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
PANTHER	PTHR22884:SF10. PTHR22884:SF10. 1 hit.
Pfam	PF05965. FYRC. 1 hit. PF05964. FYRN. 1 hit. PF00575. S1. 1 hit. PF00856. SET. 1 hit. PF03876. SHS2_Rpb7-N. 1 hit. [Graphical view]
SMART	SM00249. PHD. 4 hits. SM00508. PostSET. 1 hit. SM00184. RING. 4 hits. SM00316. S1. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 3 hits. SSF50249. Nucleic_acid_OB. 1 hit. SSF88798. RNA_pol_Rpb7_N. 1 hit.
PROSITE	PS51543. FYRC. 1 hit. PS51542. FYRN. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS50016. ZF_PHD_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E0VC46_PEDHC

Accession

Primary (citable) accession number: E0VC46

Entry history

Integrated into UniProtKB/TrEMBL:	November 2, 2010
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)