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Protein
Submitted name:

Angiotensin-converting enzyme, putative

Gene

Phum_PHUM034490

Organism
Pediculus humanus subsp. corporis (Body louse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotationImported, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM02.005.

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin-converting enzyme, putativeImported (EC:3.4.15.1Imported)
Gene namesi
ORF Names:Phum_PHUM034490Imported
OrganismiPediculus humanus subsp. corporis (Body louse)Imported
Taxonomic identifieri121224 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraPhthirapteraAnopluraPediculidaePediculus
ProteomesiUP000009046 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi121225.PHUM034490-PA.

Structurei

3D structure databases

ProteinModelPortaliE0VAB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Phylogenomic databases

InParanoidiE0VAB8.
KOiK01283.
OMAiWWELRLR.
OrthoDBiEOG7N37C7.
PhylomeDBiE0VAB8.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

E0VAB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLFLFLFA KFAFSQDTTN IEGNNESLEE ALQFLREYDV EGSAICTRVT
60 70 80 90 100
LAQWNFSTNV STINRKKMVC YNKCGNDYGR TVMEQTLYDK FQKLSRRKAT
110 120 130 140 150
EFAWTKLPDP DVRRQMKKLI TQGRFSLHDD QFNELKDVIS QMKEIYTKGT
160 170 180 190 200
ICPYNKNPVY CDQKLEPTLT KIMAKSRDYH ELLHVWKSWR DAVGPPIRQK
210 220 230 240 250
YIRYVELANQ AARLDGFNDA GDQMKSVYEI PNFEDHLSEL WNMIEPFYKQ
260 270 280 290 300
LHAYVRRKLI KFYGSKYIRH DGPIPAHLLG NMWAQSWKNI EELIIPYPGK
310 320 330 340 350
TIGDITPELI RQVAEEFFIS LGLKPMPPEF WRHSLLEKPI GREVVCRASA
360 370 380 390 400
WDFCNKMDYR IKQCTEVTME DFLTIHHEMA HIEYYLQYAD QPYLYREGAN
410 420 430 440 450
PAFHEAVGDV IVLSVQTPRH LQRIGLLNNI TDDYETNINY LLSMALEKVV
460 470 480 490 500
YLPFAYIVDK WRWNVFAEGI NNMNSKWWEL KLNYQGLIPP VPRSESDFDA
510 520 530 540 550
AAKYHVASDT PYIRYFLSVI IQFQLYESLC EASGHYGPLH TCDIYRSREA
560 570 580 590 600
GRLLREILQS GSSRSWSDVI NVMTKGKIKK ISASSLLNYF KPLLTWLEVQ
610 620
NKEELYVGWT TGPHDTGKIM DDVITRR
Length:627
Mass (Da):73,489
Last modified:November 2, 2010 - v1
Checksum:i830344A1E3864A2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235005 Genomic DNA. Translation: EEB10324.1.
RefSeqiXP_002423062.1. XM_002423017.1.

Genome annotation databases

EnsemblMetazoaiPHUM034490-RA; PHUM034490-PA; PHUM034490.
GeneIDi8232297.
KEGGiphu:Phum_PHUM034490.
VectorBaseiPHUM034490. Pediculus humanus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS235005 Genomic DNA. Translation: EEB10324.1.
RefSeqiXP_002423062.1. XM_002423017.1.

3D structure databases

ProteinModelPortaliE0VAB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi121225.PHUM034490-PA.

Protein family/group databases

MEROPSiM02.005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiPHUM034490-RA; PHUM034490-PA; PHUM034490.
GeneIDi8232297.
KEGGiphu:Phum_PHUM034490.
VectorBaseiPHUM034490. Pediculus humanus.

Organism-specific databases

CTDi8232297.

Phylogenomic databases

InParanoidiE0VAB8.
KOiK01283.
OMAiWWELRLR.
OrthoDBiEOG7N37C7.
PhylomeDBiE0VAB8.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle."
    Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A., Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E., Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A., Veenstra J.A., Walenz B., Tubio J.M.
    , Ribeiro J.M., Rozas J., Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L., Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M., Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P., Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M., Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F., Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G., Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C., Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L., Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C., Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M., Pittendrigh B.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USDAImported.

Entry informationi

Entry nameiE0VAB8_PEDHC
AccessioniPrimary (citable) accession number: E0VAB8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 24, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.