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E0UV72 (E0UV72_SULAO) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Elongation factor 4 HAMAP-Rule MF_00071
Short name=EF-4 HAMAP-Rule MF_00071
EC=3.6.5.n1 HAMAP-Rule MF_00071
Alternative name(s):
Ribosomal back-translocase LepA HAMAP-Rule MF_00071
Gene names
Name:lepA HAMAP-Rule MF_00071
Ordered Locus Names:Saut_1607
OrganismSulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10) [Complete proteome] [HAMAP] EMBL ADN09654.1
Taxonomic identifier563040 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas ›

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner By similarity. HAMAP-Rule MF_00071

Catalytic activity

GTP + H2O = GDP + phosphate. HAMAP-Rule MF_00071

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_00071.

Sequence similarities

Belongs to the GTP-binding elongation factor family. LepA subfamily. HAMAP-Rule MF_00071

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding14 – 196GTP By similarity HAMAP-Rule MF_00071
Nucleotide binding130 – 1334GTP By similarity HAMAP-Rule MF_00071

Sequences

Sequence LengthMass (Da)Tools
E0UV72 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 6A30E243C76F4851

FASTA59666,123
        10         20         30         40         50         60 
MKNIRNFSII AHIDHGKSTL ADRIIQECGS VTEREMGTQM MDTMDIEQER GITIKAQSVR 

        70         80         90        100        110        120 
LDYVKDGEHY ILNLIDTPGH VDFSYEVSKS LASSDGALLI VDAAQGVEAQ TIANVYLALD 

       130        140        150        160        170        180 
NDLEIIPVIN KIDLPAADPD KVAEEIETSI GIDATDAVLV SAKTGVGIRE LIDAIVERVP 

       190        200        210        220        230        240 
APQGNPEAPT KAIIYDSWFD QYLGALALVR VFDGEIKKNQ TIKLMSNNEE HQVLDLMYPH 

       250        260        270        280        290        300 
PLKKIKTPAI KSGEIGIVVL GLKEVSVVNV GDTITDAKNP TAEPVGNYEP AKPFVFAGLY 

       310        320        330        340        350        360 
PIDTDKFEEL RDALDKLKLN DSSLSYEPET SIALGFGFRV GFLGMLHMEV IKERLEREFG 

       370        380        390        400        410        420 
LDLIATAPSV VYHVYLNNGD MIEVQNPSEL PEVNHIDRIE EPYVKATVIT PSEYLGNIMN 

       430        440        450        460        470        480 
LLVSKRGIQN KMTYLNEDRV MLEYEIPMNE IVVDFYDTLK SISKGYASFD YEPTDFKEGD 

       490        500        510        520        530        540 
LVKLDVKVAG EVVDALSVIV PRTSALSRGR TLVKNMKELI PRQLFEVAVQ ASLGNQVIAR 

       550        560        570        580        590 
ETVKSMGKNV TAKCYGGDIT RKRKLLEKQK AGKKRMKSIG KVQLPQEAFM SVLKMD

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002205 Genomic DNA. Translation: ADN09654.1.
RefSeqYP_003892666.1. NC_014506.1.

3D structure databases

ProteinModelPortalE0UV72.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADN09654; ADN09654; Saut_1607.
GeneID9759156.
KEGGsua:Saut_1607.
PATRIC42442836. VBISulAut92361_1617.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000020624.
KOK03596.
OMAKCYGGDA.

Enzyme and pathway databases

BioCycSAUT563040:GH0V-1646-MONOMER.

Family and domain databases

Gene3D3.30.70.240. 1 hit.
HAMAPMF_00071. LepA.
InterProIPR006297. EF-4.
IPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR013842. LepA_GTP-bd_C.
IPR005225. Small_GTP-bd_dom.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR009000. Transl_elong_init/rib_B-barrel.
[Graphical view]
PANTHERPTHR23115:SF40. PTHR23115:SF40. 1 hit.
PfamPF00679. EFG_C. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF06421. LepA_C. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SMARTSM00838. EFG_C. 1 hit.
[Graphical view]
SUPFAMSSF54980. EFG_III_V. 2 hits.
SSF50447. Translat_factor. 1 hit.
TIGRFAMsTIGR01393. lepA. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE0UV72_SULAO
AccessionPrimary (citable) accession number: E0UV72
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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