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Protein

Alanine racemase

Gene

Saut_0345

Organism
Sulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Active sitei248 – 2481Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei293 – 2931Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSAUT563040:GH0V-356-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:Saut_0345Imported
OrganismiSulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)Imported
Taxonomic identifieri563040 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000007803 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE0UUF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiYGIKSVF.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0UUF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYITLNKNH FFNNLTIIAK LTKAKDKIAL VLKDNAYGHG LFEIATLAKE
60 70 80 90 100
YGITKAVVRS NEEAKEIENL FEYILVLADT PKEASQKIRY TINDIRQIQK
110 120 130 140 150
FAKNTKVELK VDTGMCRNGI MMDELEEAFI LCAQQGLQLE AVFTHHSSAD
160 170 180 190 200
EDNRYFDLQN ENFKRVKQDS QVLAKKYSFI PLRFHSFNSA ALFRSNDFDE
210 220 230 240 250
DMARVGIAAY GCLELPSSLH VKNLQPVLSV YAQRLSSRRL QKGECVGYGA
260 270 280 290 300
AFETAVTCNV SNYDFGYGDG FLRSCSHHYI TPEGIKIAGR ISMDNSSFLT
310 320 330
NKEKLLIFDD ARVIAKFADT ISYEILTALK EKIKREVLH
Length:339
Mass (Da):38,475
Last modified:November 1, 2010 - v1
Checksum:i2BBADACE965C8857
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002205 Genomic DNA. Translation: ADN08394.1.
RefSeqiYP_003891406.1. NC_014506.1.

Genome annotation databases

EnsemblBacteriaiADN08394; ADN08394; Saut_0345.
KEGGisua:Saut_0345.
PATRICi42440238. VBISulAut92361_0345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002205 Genomic DNA. Translation: ADN08394.1.
RefSeqiYP_003891406.1. NC_014506.1.

3D structure databases

ProteinModelPortaliE0UUF8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADN08394; ADN08394; Saut_0345.
KEGGisua:Saut_0345.
PATRICi42440238. VBISulAut92361_0345.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiYGIKSVF.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSAUT563040:GH0V-356-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10Imported.

Entry informationi

Entry nameiE0UUF8_SULAO
AccessioniPrimary (citable) accession number: E0UUF8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 2010
Last sequence update: November 1, 2010
Last modified: March 31, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.