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E0UU39

- E0UU39_SULAO

UniProt

E0UU39 - E0UU39_SULAO

Protein

Aspartate 1-decarboxylase

Gene

panD

Organism
Sulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.UniRule annotationSAAS annotation

    Catalytic activityi

    L-aspartate = beta-alanine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Pyruvoyl group.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation
    Binding sitei57 – 571SubstrateUniRule annotation
    Active sitei58 – 581Proton donorUniRule annotation

    GO - Molecular functioni

    1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. alanine biosynthetic process Source: InterPro
    2. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Pantothenate biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    PyruvateUniRule annotationSAAS annotation, Schiff baseUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSAUT563040:GH0V-305-MONOMER.
    UniPathwayiUPA00028; UER00002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate 1-decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
    Alternative name(s):
    Aspartate alpha-decarboxylaseUniRule annotation
    Gene namesi
    Name:panDUniRule annotationImported
    Ordered Locus Names:Saut_0299Imported
    OrganismiSulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)Imported
    Taxonomic identifieri563040 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
    ProteomesiUP000007803: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Pyruvic acid (Ser)UniRule annotation

    Post-translational modificationi

    Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.UniRule annotation

    Keywords - PTMi

    Autocatalytic cleavageUniRule annotation, ZymogenUniRule annotation

    Interactioni

    Subunit structurei

    Heterooctamer of four alpha and four beta subunits.UniRule annotationSAAS annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 753Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PanD family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000221007.
    KOiK01579.
    OMAiWYDGSCA.

    Family and domain databases

    HAMAPiMF_00446. PanD.
    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view]
    PANTHERiPTHR21012. PTHR21012. 1 hit.
    PfamiPF02261. Asp_decarbox. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
    SUPFAMiSSF50692. SSF50692. 1 hit.
    TIGRFAMsiTIGR00223. panD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E0UU39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIEMLYSKI HRATVTDANL NYVGSITIDE ELLEASKMRV GQKVEILNIN    50
    NGERFSTYII LGERGKRDIC LNGAAARKVH KGDKIIVVAY ATYDERELEN 100
    YKPRVVLLND ENNIDAIHEE I 121
    Length:121
    Mass (Da):13,780
    Last modified:November 2, 2010 - v1
    Checksum:iCDC69F831D544668
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002205 Genomic DNA. Translation: ADN08348.1.
    RefSeqiWP_013326104.1. NC_014506.1.
    YP_003891360.1. NC_014506.1.

    Genome annotation databases

    EnsemblBacteriaiADN08348; ADN08348; Saut_0299.
    GeneIDi9757815.
    KEGGisua:Saut_0299.
    PATRICi42440132. VBISulAut92361_0297.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002205 Genomic DNA. Translation: ADN08348.1 .
    RefSeqi WP_013326104.1. NC_014506.1.
    YP_003891360.1. NC_014506.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADN08348 ; ADN08348 ; Saut_0299 .
    GeneIDi 9757815.
    KEGGi sua:Saut_0299.
    PATRICi 42440132. VBISulAut92361_0297.

    Phylogenomic databases

    HOGENOMi HOG000221007.
    KOi K01579.
    OMAi WYDGSCA.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00002 .
    BioCyci SAUT563040:GH0V-305-MONOMER.

    Family and domain databases

    HAMAPi MF_00446. PanD.
    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view ]
    PANTHERi PTHR21012. PTHR21012. 1 hit.
    Pfami PF02261. Asp_decarbox. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
    SUPFAMi SSF50692. SSF50692. 1 hit.
    TIGRFAMsi TIGR00223. panD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10Imported.

    Entry informationi

    Entry nameiE0UU39_SULAO
    AccessioniPrimary (citable) accession number: E0UU39
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3