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E0UU39

- E0UU39_SULAO

UniProt

E0UU39 - E0UU39_SULAO

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Protein

Aspartate 1-decarboxylase

Gene

panD

Organism
Sulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.UniRule annotationSAAS annotation

Catalytic activityi

L-aspartate = beta-alanine + CO2.UniRule annotationSAAS annotation

Cofactori

Pyruvoyl group.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation
Binding sitei57 – 571SubstrateUniRule annotation
Active sitei58 – 581Proton donorUniRule annotation

GO - Molecular functioni

  1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. alanine biosynthetic process Source: InterPro
  2. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotation, Lyase

Keywords - Biological processi

Pantothenate biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

PyruvateUniRule annotation, Schiff baseUniRule annotation

Enzyme and pathway databases

BioCyciSAUT563040:GH0V-305-MONOMER.
UniPathwayiUPA00028; UER00002.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate 1-decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
Alternative name(s):
Aspartate alpha-decarboxylaseUniRule annotation
Gene namesi
Name:panDUniRule annotation
Ordered Locus Names:Saut_0299Imported
OrganismiSulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)Imported
Taxonomic identifieri563040 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000007803: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyruvic acid (Ser)UniRule annotation

Post-translational modificationi

Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.UniRule annotation

Keywords - PTMi

Autocatalytic cleavageUniRule annotation, ZymogenUniRule annotation

Interactioni

Subunit structurei

Heterooctamer of four alpha and four beta subunits.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 753Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PanD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221007.
KOiK01579.
OMAiWYDGSCA.

Family and domain databases

HAMAPiMF_00446. PanD.
InterProiIPR009010. Asp_de-COase-like_dom.
IPR003190. Asp_decarbox.
[Graphical view]
PANTHERiPTHR21012. PTHR21012. 1 hit.
PfamiPF02261. Asp_decarbox. 1 hit.
[Graphical view]
PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR00223. panD. 1 hit.

Sequencei

Sequence statusi: Complete.

E0UU39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIEMLYSKI HRATVTDANL NYVGSITIDE ELLEASKMRV GQKVEILNIN
60 70 80 90 100
NGERFSTYII LGERGKRDIC LNGAAARKVH KGDKIIVVAY ATYDERELEN
110 120
YKPRVVLLND ENNIDAIHEE I
Length:121
Mass (Da):13,780
Last modified:November 2, 2010 - v1
Checksum:iCDC69F831D544668
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002205 Genomic DNA. Translation: ADN08348.1.
RefSeqiYP_003891360.1. NC_014506.1.

Genome annotation databases

EnsemblBacteriaiADN08348; ADN08348; Saut_0299.
GeneIDi9757815.
KEGGisua:Saut_0299.
PATRICi42440132. VBISulAut92361_0297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002205 Genomic DNA. Translation: ADN08348.1 .
RefSeqi YP_003891360.1. NC_014506.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADN08348 ; ADN08348 ; Saut_0299 .
GeneIDi 9757815.
KEGGi sua:Saut_0299.
PATRICi 42440132. VBISulAut92361_0297.

Phylogenomic databases

HOGENOMi HOG000221007.
KOi K01579.
OMAi WYDGSCA.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00002 .
BioCyci SAUT563040:GH0V-305-MONOMER.

Family and domain databases

HAMAPi MF_00446. PanD.
InterProi IPR009010. Asp_de-COase-like_dom.
IPR003190. Asp_decarbox.
[Graphical view ]
PANTHERi PTHR21012. PTHR21012. 1 hit.
Pfami PF02261. Asp_decarbox. 1 hit.
[Graphical view ]
PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR00223. panD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10Imported.

Entry informationi

Entry nameiE0UU39_SULAO
AccessioniPrimary (citable) accession number: E0UU39
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3