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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Sulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei62SubstrateUniRule annotation1
Active sitei89Proton donor/acceptorUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Sitei184Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSAUT563040:G1GMZ-488-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:Saut_0488Imported
OrganismiSulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)Imported
Taxonomic identifieri563040 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
Proteomesi
  • UP000007803 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi563040.Saut_0488

Structurei

3D structure databases

ProteinModelPortaliE0UP73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 17Substrate bindingUniRule annotation8
Regioni23 – 24Substrate bindingUniRule annotation2
Regioni89 – 92Substrate bindingUniRule annotation4
Regioni116 – 117Substrate bindingUniRule annotation2
Regioni185 – 186Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DKJ Bacteria
COG0588 LUCA
HOGENOMiHOG000221682
KOiK01834
OMAiRMLPYWY
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.12401 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

E0UP73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKARLVLVR HGQSIYNQKN IFTGWTDIDL SEQGIDEAKK AGLLLKKNNI
60 70 80 90 100
YPDICFTSWL NRAIHTAQIL LKELEWEHID SLRSYKLNER HYGDWQGRDK
110 120 130 140 150
DEVKNEYGEE KFLAVRRGYD VAPPPLKPND ARCVSNDKKY ANIDKKLLPL
160 170 180 190 200
NESLKDTKKR VLEYYSEQII SKLQEQKTVL ISAHGNSLRA LVMELEQISE
210 220 230
TNIVSFEIPT GEIIVYTFDC DMKIIEKNVL IG
Length:232
Mass (Da):26,858
Last modified:November 2, 2010 - v1
Checksum:i8B2FFD0EC8C2F9CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002205 Genomic DNA Translation: ADN08537.1
RefSeqiWP_013326293.1, NC_014506.1

Genome annotation databases

EnsemblBacteriaiADN08537; ADN08537; Saut_0488
KEGGisua:Saut_0488

Similar proteinsi

Entry informationi

Entry nameiE0UP73_SULAO
AccessioniPrimary (citable) accession number: E0UP73
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported