ID   E0UHW8_GLOV7            Unreviewed;       724 AA.
AC   E0UHW8;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ADN14498.1};
GN   OrderedLocusNames=Cyan7822_2526 {ECO:0000313|EMBL:ADN14498.1};
OS   Gloeothece verrucosa (strain PCC 7822) (Cyanothece sp. (strain PCC 7822)).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Chroococcales; Aphanothecaceae; Gloeothece; Gloeothece verrucosa.
OX   NCBI_TaxID=497965 {ECO:0000313|EMBL:ADN14498.1, ECO:0000313|Proteomes:UP000008206};
RN   [1] {ECO:0000313|Proteomes:UP000008206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7822 {ECO:0000313|Proteomes:UP000008206};
RX   PubMed=21972240; DOI=10.1128/mBio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
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DR   EMBL; CP002198; ADN14498.1; -; Genomic_DNA.
DR   RefSeq; WP_013322603.1; NC_014501.1.
DR   AlphaFoldDB; E0UHW8; -.
DR   STRING; 497965.Cyan7822_2526; -.
DR   KEGG; cyj:Cyan7822_2526; -.
DR   eggNOG; COG0745; Bacteria.
DR   eggNOG; COG2199; Bacteria.
DR   eggNOG; COG2200; Bacteria.
DR   eggNOG; COG3829; Bacteria.
DR   HOGENOM; CLU_000445_70_50_3; -.
DR   OrthoDB; 9813903at2; -.
DR   Proteomes; UP000008206; Chromosome.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 1.
DR   CDD; cd19920; REC_PA4781-like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF08448; PAS_4; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008206}.
FT   DOMAIN          12..128
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          161..234
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          230..291
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          323..456
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          467..724
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
FT   MOD_RES         61
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   724 AA;  81636 MW;  9AFB12EB574C3B70 CRC64;
     MKEDPLADCK GSILIVDDLP DNLRLLRDTL KGQGYKVRSC TTGAMVLRGA KAAVTDLILL
     DIKLPDMDGY EICRQLKADE QTASIPVIFL SALNNTFDKV QGFTFGGADY ITKPFQVEEV
     LARVATHLSI VRLQKSLKAQ NVQLIQEIEE RKRIEEALFI EKELAQVTLK SIGDAVITTD
     AQGNISYINP VAEALTGWSH QDAQGLPLFE VFYIVNEESN KPVENPATKA LDEVRIVNLA
     KNTLLIARDG RQYPIDDSAA PIQDSQGRVI GAVIVFRDIT ESRSLTRQLS WQASHDSLTG
     LINRLGFEQQ LEAAIKSAKN EHQHHVLCYL DLDQFKVVND TCGHAAGDEL LREVTSLLQQ
     RVRSSDILAR LGGDEFAVLL NQCSLEKATE IAETFRQLID KFRFSWNNKS FSIGVSIGVV
     AIDYTSKDKN SVLSVADAAC YAAKGKGRNC VQVYQADDHE LLRQRRERQW VVQINQALEE
     NRFCLYYQKI APINSLVKPV YYEILLRLLN EQGNIVSPGI FIPAAERYGL MPAIDRWVIS
     TFFQKYQQFY EQHLGKIDFS QKLYGINLSG ASINNEHFLD FLKEQFNQFN VPYHTICFEI
     TETTAIANFQ QAIHLINELK KLGCCFAIDD FGHGMNSFDY LKNFPVDYLK IDGSFVKNLV
     NSSIDIAIVE SFNRIGHVMN LKTIAEFVEN IAILEKVQAI GLDYAQGYEI ARPSPFEFEN
     THYD
//