ID   E0UH64_GLOV7            Unreviewed;       688 AA.
AC   E0UH64;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ADN15663.1};
GN   OrderedLocusNames=Cyan7822_3727 {ECO:0000313|EMBL:ADN15663.1};
OS   Gloeothece verrucosa (strain PCC 7822) (Cyanothece sp. (strain PCC 7822)).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Chroococcales; Aphanothecaceae; Gloeothece; Gloeothece verrucosa.
OX   NCBI_TaxID=497965 {ECO:0000313|EMBL:ADN15663.1, ECO:0000313|Proteomes:UP000008206};
RN   [1] {ECO:0000313|Proteomes:UP000008206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7822 {ECO:0000313|Proteomes:UP000008206};
RX   PubMed=21972240; DOI=10.1128/mBio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
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DR   EMBL; CP002198; ADN15663.1; -; Genomic_DNA.
DR   RefSeq; WP_013323732.1; NC_014501.1.
DR   AlphaFoldDB; E0UH64; -.
DR   STRING; 497965.Cyan7822_3727; -.
DR   KEGG; cyj:Cyan7822_3727; -.
DR   eggNOG; COG1716; Bacteria.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_70_20_3; -.
DR   OrthoDB; 415644at2; -.
DR   Proteomes; UP000008206; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50889; S4; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008206};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT   DOMAIN          23..82
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   DOMAIN          289..422
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          431..685
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   688 AA;  78815 MW;  FF9E4BD4E508FD20 CRC64;
     MLHRLIINSS NFRKIIDLQE SFYTIGRHST NSIILPSPKI SKKHAIIVKI SGEKPQKVFQ
     IIDGDEQGNR SKNGIFVNGK KVLKHQLKHG DIINFDKDIK VTYYIIHVTS NYFINLPASE
     TSFQPSTEVF VNAQWDQTET EEKQILLPES YLSKLASLVE FSPNPIIEIN FAGEITYLNS
     AAIQKFKTIQ KEKINHPIFR NLLEQEFHQD GNLLIREIKI GQEIFEQHIH YLNDSQLIRS
     YIFDITERKL AEEILHYQAY YDTLTGLPNK ILFNQQLATA LADAHFKNTL LAVLFIDLDG
     FQNVNDTLGH STGDQLLRSF AQRLKTRLCA GDFFARWAGD EFTILVPYLE NIEEAKNLAQ
     RIFNILQQPF NISDNLLYLK ASIGIAIYPQ DGEDAETLVK NADAALYRSK EIGKNNYQFY
     NPIITSKSCQ RLQIENLLHQ ALEKEQFLLH YQPQINIKTG QVLGMEALIR WQHPELGLIS
     PTKFIPIAEE TGLIVNIGEW VLRQACLQNQ FWQKMGLPPI RIAVNLSPQQ FQQPNFINVV
     TQILKETDLE AHFLELEITE TTIMENIDFA CQVISYFQTM GVHISMDDFG TGYSSLGYLK
     QIPLNSIKID QTFVKDLKEH PQDLAIISAV LAIGRGFNLR VIAEGVETQY QVDLLKKLEC
     EEMQGFKFSK PLTPEDAAKF LWSSPFNS
//