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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Cyanothece sp. (strain PCC 7822)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120Substrate; in homodimeric partnerUniRule annotation1
Binding sitei170SubstrateUniRule annotation1
Active sitei172Proton acceptorUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Metal bindingi198Magnesium; via carbamate groupUniRule annotation1
Metal bindingi200MagnesiumUniRule annotation1
Metal bindingi201MagnesiumUniRule annotation1
Active sitei291Proton acceptorUniRule annotation1
Binding sitei292SubstrateUniRule annotation1
Binding sitei324SubstrateUniRule annotation1
Sitei331Transition state stabilizerUniRule annotation1
Binding sitei376SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase
Biological processCalvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotorespirationUniRule annotation, PhotosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Synonyms:rbcLUniRule annotation
Ordered Locus Names:Cyan7822_2899Imported
OrganismiCyanothece sp. (strain PCC 7822)Imported
Taxonomic identifieri497965 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesCyanothecaceaeCyanothece
Proteomesi
  • UP000008206 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Protein-protein interaction databases

STRINGi497965.Cyan7822_2899.

Structurei

3D structure databases

ProteinModelPortaliE0U7P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 140RuBisCO_large_NInterPro annotationAdd BLAST120
Domaini151 – 459RuBisCO_largeInterPro annotationAdd BLAST309

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1. Bacteria.
COG1850. LUCA.
HOGENOMiHOG000230831.
KOiK01601.
OMAiHRAMHAA.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08212. RuBisCO_large_I. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1. 1 hit.
InterProiView protein in InterPro
IPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR020888. RuBisCO_lsuI.
PfamiView protein in Pfam
PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
SFLDiSFLDS00014. RuBisCO. 1 hit.
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiView protein in PROSITE
PS00157. RUBISCO_LARGE. 1 hit.

Sequencei

Sequence statusi: Complete.

E0U7P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSKAKGGF QAGVKDYRLT YYTPDYTPKD TDLLACFRVT PQPGVPPEEA
60 70 80 90 100
GAAVAAESST GTWTTVWTDG LTDLDRYKGR CYDIEPVPNE DNQYFCFVAY
110 120 130 140 150
PLDLFEEGSV TNILTSIVGN VFGFKALRAL RLEDIRFPVA LLKTFQGPPH
160 170 180 190 200
GITVERDKLN KYGRPLLGCT IKPKLGLSAK NYGRAVYECL RGGLDFTKDD
210 220 230 240 250
ENINSQPFMR WRDRFLFVQE AIEKAQAETN EIKGHYLNVT AGTLEEMMKR
260 270 280 290 300
AEFAKEIKTP IIMHDYLTGG FTANTTLAKF CRDNGLLLHI HRAMHAVIDR
310 320 330 340 350
QKNHGIHFRV LAKCLRMSGG DHLHSGTVVG KLEGERGITM GFVDLMREDY
360 370 380 390 400
VEEDRARGIF FTQDWASMPG VMPVASGGIH VWHMPALVEI FGDDSCLQFG
410 420 430 440 450
GGTLGHPWGN APGATANRVA LEACIQARNE GRSLAREGNE VIREAARWSP
460 470
ELAAACELWK EIKFEFEAMD TL
Length:472
Mass (Da):52,657
Last modified:November 2, 2010 - v1
Checksum:iCE42E983A700A93A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002198 Genomic DNA. Translation: ADN14857.1.
RefSeqiWP_013322960.1. NC_014501.1.

Genome annotation databases

EnsemblBacteriaiADN14857; ADN14857; Cyan7822_2899.
KEGGicyj:Cyan7822_2899.

Similar proteinsi

Entry informationi

Entry nameiE0U7P5_CYAP2
AccessioniPrimary (citable) accession number: E0U7P5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: September 27, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported