ID   E0U7K8_GLOV7            Unreviewed;      1409 AA.
AC   E0U7K8;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ADN13704.1};
GN   OrderedLocusNames=Cyan7822_1716 {ECO:0000313|EMBL:ADN13704.1};
OS   Gloeothece verrucosa (strain PCC 7822) (Cyanothece sp. (strain PCC 7822)).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Chroococcales; Aphanothecaceae; Gloeothece; Gloeothece verrucosa.
OX   NCBI_TaxID=497965 {ECO:0000313|EMBL:ADN13704.1, ECO:0000313|Proteomes:UP000008206};
RN   [1] {ECO:0000313|Proteomes:UP000008206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7822 {ECO:0000313|Proteomes:UP000008206};
RX   PubMed=21972240; DOI=10.1128/mBio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
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DR   EMBL; CP002198; ADN13704.1; -; Genomic_DNA.
DR   RefSeq; WP_013321811.1; NC_014501.1.
DR   STRING; 497965.Cyan7822_1716; -.
DR   KEGG; cyj:Cyan7822_1716; -.
DR   eggNOG; COG0834; Bacteria.
DR   eggNOG; COG2202; Bacteria.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_004508_0_0_3; -.
DR   OrthoDB; 425396at2; -.
DR   Proteomes; UP000008206; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 4.
DR   CDD; cd13704; PBP2_HisK; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 5.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001638; Solute-binding_3/MltF_N.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   NCBIfam; TIGR00229; sensory_box; 5.
DR   PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF08447; PAS_3; 2.
DR   Pfam; PF13188; PAS_8; 1.
DR   Pfam; PF13426; PAS_9; 2.
DR   Pfam; PF00497; SBP_bac_3; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00086; PAC; 5.
DR   SMART; SM00091; PAS; 5.
DR   SMART; SM00062; PBPb; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 5.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50113; PAC; 3.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008206};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        268..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          380..432
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          555..608
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          728..792
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          852..894
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          927..979
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          1012..1145
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          1154..1409
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
FT   COILED          416..482
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1409 AA;  162596 MW;  ECCB81B0E5592BA0 CRC64;
     MKTIIKIVYL GFFSLLLASQ LFCLKGVAQD TDQVSLLEVT AVIPKYFPPL YLVDRTGKPS
     GFAIDVMKEV AKLAQLKVRY EIKNTWSEVQ ETLINGNADL IPNLGITPAR QTQMSFTAPV
     ETDSVSVFVR ASNHQIKTVA HLAGHRVGVV KGTVGYEIAK NRQNIQLEVF DGIEYGVFEL
     LAGHVDALIY SESVLKEIVA QADVSNRIKI LGEPLAEIKR AIALRKDNLL LLTRLDKAVN
     SFVGSPKYEQ IYRKWYGEPE NFWTVGRLFW LMSGLLITTI LLMSLWRYIS LRPFYRLQQI
     EAALRASESR YRGIVEDQSE FICRYRPGGT LTFVNQAYCR YFQKTPAAVL DNTFWDLIYS
     EDQPQVAQNI ASLTPENPMI THEHRVRLSS GEIRWNQWTN RVIMDEKRNI IEFQAVGRDI
     TQLKQVEAAL RQLNEELEQR VEQRTAELAA EIRERQEIET ALIKSQAKYE QLVEKLSKSE
     ERLQLALEGS GDTIWEWNLG TGELYCDPNW IRRLGYDPRE EAINIEWWRS KIDPETLSDH
     EAALENYLNG KTEYLALEYK IQTLEGEWLW IGGRGKCIAY DQQRKPLKIL GTHRDITETK
     QTQENLRQQQ ELLKTIVEQI PVMLAYFDQH YNLLWVNREW EKIWGWSLEN RQKGDLLAEF
     EPESEYRQSV LNYIKSAQGK WRDFKILVRD GRIIDTSWAN VKLSDGTSIA IGQDITERKR
     IEEILRESEE KYRLFFDANP NPLWVYDLET FAFLEVNQAT IEHYGYTREE FLAMTIRDIR
     PPEDVPLLEQ YILQINPHFN RSGQWRHRKA NGEIIDVEIT SHGLEYAGRK ARLVLAHDIT
     ERLKAEKALQ ESKERFHRAI VDAPLPILIH AEDGEIVQVN HAWTELSGYH LDELSTIADW
     TEKAYGERKD IVRSVIDQLY EIDGKVEEGE FAITIKSGET RIWDFSSAPL GKLADGRRLI
     ISMAIDITER KQAEEQLRHS VLHDGLTGLP NRTLLLDRVE QAIKRKQQQP NYLFAILFID
     LDRFKVVNDS LGHLVGDQLL KTIADKLQRC VRPTDTVARF GGDEFVILLE DLTIWTDATK
     MAQRITEEFE SSFTLQEQEY FTSASIGITF CSSPEQTPSE LVRNADIAMY RSKEAGRARY
     TMFDPIMHTQ ATQLLELETN LRLALEREEF IVYYQPIVSL MNRNLLGFEA LVRWIHPEKG
     VISPANFIPV AEETGLIIPL GEWVLRESCR QMKAWQEQFI GAENLRVSVN LSGKQLQQPN
     LINRIDNILT ETGLEGKNLK LEITESMLMN NKEQVSELLL QMKAKKIQVS IDDFGTGYSS
     LSYLHYLPVD TLKIDRSFVS RMSQVGENFE IVEAIITLAH HLQMDVVAEG VETEQHLRQL
     QQLGCEFGQG YFFSKPLESE KIVSWLERL
//