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E0U490

- E0U490_BACPZ

UniProt

E0U490 - E0U490_BACPZ

Protein

Protein translocase subunit SecA

Gene

secA

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

    Cofactori

    May bind 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi825 – 8251ZincUniRule annotation
    Metal bindingi827 – 8271ZincUniRule annotation
    Metal bindingi836 – 8361ZincUniRule annotation
    Metal bindingi837 – 8371ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1078ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. helicase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein import Source: InterPro
    3. protein targeting Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, TranslocationUniRule annotationSAAS annotation, Transport

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBSUB655816:GCOR-3538-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecAUniRule annotation
    Gene namesi
    Name:secAUniRule annotationImported
    Ordered Locus Names:BSUW23_17300Imported
    OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)Imported
    Taxonomic identifieri655816 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000002233: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Cytoplasm UniRule annotation
    Note: Distribution is 50-50.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membraneUniRule annotationSAAS annotation, CytoplasmUniRule annotationSAAS annotation, Membrane

    Interactioni

    Subunit structurei

    Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecA family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000218169.
    KOiK03070.
    OMAiEAYEFQQ.

    Family and domain databases

    Gene3Di1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPiMF_01382. SecA.
    InterProiIPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view]
    PfamiPF00271. Helicase_C. 1 hit.
    PF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view]
    PRINTSiPR00906. SECA.
    SMARTiSM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsiTIGR00963. secA. 1 hit.
    PROSITEiPS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0U490-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGILNKMFD PTKRTLNRYE RIANDIDAVR GDYENLSDDA LKHKTIEFKE    50
    RLEKGATTDD LLVEAFAVVR EASRRVTGMF PFKVQLMGGV ALHDGNIAEM 100
    KTGEGKTLTS TLPVYLNALT GKGVHIVTVN EYLASRDAEQ MGKIFEFLGM 150
    TVGLNLNSMS KDEKREAYAA DITYSTNNEL GFDYLRDNMV LYKEQMVQRP 200
    LHFAVIDEVD SILIDEARTP LIISGQAAKS TKLYVQANAF VRTLKAEKDY 250
    TYDIKTKGVQ LTEEGMTKAE KAFGIDNLFD VKHVALNHHI NQSLKAHAAM 300
    QKDVDYVVED GQVVIVDSFT GRLMKGRRYS EGLHQAIEAK EGLEIQNESM 350
    TLATITFQNY FRMYEKLAGM TGTAKTEEEE FRNIYNMQVV TIPTNKPVVR 400
    DDRPDLIYRT MEGKFKAVAE DVAQRYMTGQ PVLVGTVAVE TSELISKLLK 450
    NKGIPHQVLN AKNHEREAQI IEEAGQKGAV TIATNMAGRG TDIKLGEGVK 500
    ELGGLAVVGT ERHESRRIDN QLRGRSGRQG DPGITQFYLS MEDELMRRFG 550
    AERTMAMLDR FGMDDSTPIQ SKMVSRAVES SQKRVEGNNF DSRKQLLQYD 600
    DVLRQQREVI YKQRFEVIDS ENLREIVENM IKSSLERAIA AYTPREELPE 650
    EWKLDGLVEL VNTTYLDEGA LEKSDIFGKE PDEMHELIMD RIMTKYNEKE 700
    VKFGEEQMRE FEKVIVLRAV DSKWMDHIDA MDQLRQGIHL RAYAQTNPLR 750
    EYQMEGFTMF ENMIESIEDE VAKFVMKAEI ENNLEREEVV QGQTTAHQQQ 800
    EGDDNKKAKK APVRKVVDIG RNAPCHCGSG KKYKNCCGRT E 841
    Length:841
    Mass (Da):95,574
    Last modified:November 2, 2010 - v1
    Checksum:i62647C2588EC83A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM39495.1.
    RefSeqiYP_003867804.1. NC_014479.1.

    Genome annotation databases

    EnsemblBacteriaiADM39495; ADM39495; BSUW23_17300.
    GeneIDi9724468.
    KEGGibss:BSUW23_17300.
    PATRICi42193173. VBIBacSub57968_3533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM39495.1 .
    RefSeqi YP_003867804.1. NC_014479.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM39495 ; ADM39495 ; BSUW23_17300 .
    GeneIDi 9724468.
    KEGGi bss:BSUW23_17300.
    PATRICi 42193173. VBIBacSub57968_3533.

    Phylogenomic databases

    HOGENOMi HOG000218169.
    KOi K03070.
    OMAi EAYEFQQ.

    Enzyme and pathway databases

    BioCyci BSUB655816:GCOR-3538-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPi MF_01382. SecA.
    InterProi IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view ]
    Pfami PF00271. Helicase_C. 1 hit.
    PF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view ]
    PRINTSi PR00906. SECA.
    SMARTi SM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsi TIGR00963. secA. 1 hit.
    PROSITEi PS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
      Zeigler D.R.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23059 / NRRL B-14472 / W23Imported.
    2. Zeigler D.R.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: W23.

    Entry informationi

    Entry nameiE0U490_BACPZ
    AccessioniPrimary (citable) accession number: E0U490
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3