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E0U3Q2 (E0U3Q2_BACPZ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Name:murF
Ordered Locus Names:BSUW23_02380
OrganismBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) [Complete proteome] [HAMAP] EMBL ADM36534.1
Taxonomic identifier655816 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
E0U3Q2 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 4B666228A148FDC3

FASTA45749,815
        10         20         30         40         50         60 
MIKRTVKNIA KMVKGTLTNP QYEQTVIHGV ATDTRKLEQH QLFIPLKGEH FNGHTFVPQA 

        70         80         90        100        110        120 
FEAGVAAVLW DRSEPNPPEN QAVILVDDTL SALQQLAKAY LQELGTRVIG VTGSNGKTTT 

       130        140        150        160        170        180 
KDMIHAVLGT RYRVHKTGGN FNNHIGLPLT VLAMPEDTEI AVLEMGMSAK GEIDLLSRLA 

       190        200        210        220        230        240 
NPDAAVITNI GESHMQDLGS REGIAEAKLE IINGLKEDGV LIYIGDEPLL QKTYSCQTKT 

       250        260        270        280        290        300 
YGAGAQNDYQ LQDVSQSEEG THFTIKGMEK TFFIPILGKH NVMNAMAAIA AGAYFGITPE 

       310        320        330        340        350        360 
DAAKGLSGLK VTGMRLELIK TDSGISIIND AYNASPTSMK AAIQLTESLE GYGKKMLVLG 

       370        380        390        400        410        420 
DMLELGDLEE TFHKECGAVI SPEKIDRVFT YGKLGAFIAE GALKHFEKER VSHYTEKKDL 

       430        440        450 
LQAVKENASK GDLILFKASR GMKLEEIVKD LIESPLS

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
Zeigler D.R.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23059 / NRRL B-14472 / W23.
[2]Zeigler D.R.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: W23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002183 Genomic DNA. Translation: ADM36534.1.
RefSeqYP_003864843.1. NC_014479.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADM36534; ADM36534; BSUW23_02380.
GeneID9721438.
KEGGbss:BSUW23_02380.
PATRIC42186946. VBIBacSub57968_0480.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000268119.
KOK01929.
OMAGNRNNEI.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE0U3Q2_BACPZ
AccessionPrimary (citable) accession number: E0U3Q2
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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