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E0U0H8

- TYSY2_BACPZ

UniProt

E0U0H8 - TYSY2_BACPZ

Protein

Thymidylate synthase 2

Gene

thyA2

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei146 – 1461UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBSUB655816:GCOR-2187-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthase 2UniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TS 2UniRule annotation
    Short name:
    TSase 2UniRule annotation
    Alternative name(s):
    Thymidylate synthase BUniRule annotation
    Short name:
    TS BUniRule annotation
    Short name:
    TSase BUniRule annotation
    Gene namesi
    Name:thyA2UniRule annotation
    Synonyms:thyB
    Ordered Locus Names:BSUW23_10675
    OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
    Taxonomic identifieri655816 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000002233: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Thymidylate synthase 2PRO_0000403665Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE0U0H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000257899.
    KOiK00560.
    OMAiDVHLYSN.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 2 hits.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0U0H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQYKDLCRH VLEHGEKKGD RTGTGTISTF GYQMRFHLQE GFPMLTTKKL    50
    HFKSIAHELL WFLKGDTNVR YLQENGVRIW NEWADENGEL GPVYGSQWRS 100
    WRGADGETID QISRLIEDIK TNPNSRRLIV SAWNVGEIDK MALPPCHCLF 150
    QFYVSDGKLS CQLYQRSADV FLGVPFNIAS YALLTMMIAH VTGLEPGEFI 200
    HTFGDVHIYQ NHIEQVNLQL TRDVRPLPKL RFAREIDSIF NFAFEDFIIE 250
    DYDPHPHIKG AVSV 264
    Length:264
    Mass (Da):30,504
    Last modified:November 2, 2010 - v1
    Checksum:iD121522377066038
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM38175.1.
    RefSeqiWP_003218224.1. NC_014479.1.
    YP_003866484.1. NC_014479.1.

    Genome annotation databases

    EnsemblBacteriaiADM38175; ADM38175; BSUW23_10675.
    GeneIDi9723117.
    KEGGibss:BSUW23_10675.
    PATRICi42190405. VBIBacSub57968_2176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM38175.1 .
    RefSeqi WP_003218224.1. NC_014479.1.
    YP_003866484.1. NC_014479.1.

    3D structure databases

    ProteinModelPortali E0U0H8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM38175 ; ADM38175 ; BSUW23_10675 .
    GeneIDi 9723117.
    KEGGi bss:BSUW23_10675.
    PATRICi 42190405. VBIBacSub57968_2176.

    Phylogenomic databases

    HOGENOMi HOG000257899.
    KOi K00560.
    OMAi DVHLYSN.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci BSUB655816:GCOR-2187-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 2 hits.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
      Zeigler D.R.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23059 / NRRL B-14472 / W23.

    Entry informationi

    Entry nameiTYSY2_BACPZ
    AccessioniPrimary (citable) accession number: E0U0H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3