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E0TVT6

- TYSY1_BACPZ

UniProt

E0TVT6 - TYSY1_BACPZ

Protein

Thymidylate synthase 1

Gene

thyA1

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei161 – 1611UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBSUB655816:GCOR-1872-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthase 1UniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TS 1UniRule annotation
    Short name:
    TSase 1UniRule annotation
    Alternative name(s):
    Thymidylate synthase AUniRule annotation
    Short name:
    TS AUniRule annotation
    Short name:
    TSase AUniRule annotation
    Gene namesi
    Name:thyA1UniRule annotation
    Synonyms:thyA
    Ordered Locus Names:BSUW23_09080
    OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
    Taxonomic identifieri655816 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000002233: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Thymidylate synthase 1PRO_0000403664Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000257898.
    KOiK00560.
    OMAiTIGHAYG.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0TVT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQFDKQYNS IIKDIMNNGI SDEEFNVRTK WDSDGTPAHT LSVISKQMRF    50
    DNSEVPILTT KKVAWKTAIK ELLWIWQLKS NDVTELNKMG VHIWDQWKQE 100
    DGTIGHAYGF QLGKKNRNLN GEKVDQVDYL LHQLKNNPSS RRHITMLWNP 150
    DELDSMALTP CVYETQWYVK QGKLHLEVRA RSNDMALGNP FNVFQYNVLQ 200
    RMIAQVTGYE LGEYIFNIGD CHVYTRHIDN LKIQMEREQF EAPELWINPE 250
    VKDFYDFTID DFKLFNYKHG DKLLFEVAV 279
    Length:279
    Mass (Da):32,890
    Last modified:November 2, 2010 - v1
    Checksum:i9E808B8519B9E33C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1491N → S in AAC26325. (PubMed:9648749)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM37862.1.
    AF004103 Genomic DNA. Translation: AAC26325.1.
    PIRiI40494.
    RefSeqiYP_003866171.1. NC_014479.1.

    Genome annotation databases

    EnsemblBacteriaiADM37862; ADM37862; BSUW23_09080.
    GeneIDi9722802.
    KEGGibss:BSUW23_09080.
    PATRICi42189751. VBIBacSub57968_1850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM37862.1 .
    AF004103 Genomic DNA. Translation: AAC26325.1 .
    PIRi I40494.
    RefSeqi YP_003866171.1. NC_014479.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM37862 ; ADM37862 ; BSUW23_09080 .
    GeneIDi 9722802.
    KEGGi bss:BSUW23_09080.
    PATRICi 42189751. VBIBacSub57968_1850.

    Phylogenomic databases

    HOGENOMi HOG000257898.
    KOi K00560.
    OMAi TIGHAYG.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci BSUB655816:GCOR-1872-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
      Zeigler D.R.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23059 / NRRL B-14472 / W23.
    2. "Genes encoding thymidylate synthases A and B in the genus Bacillus are members of two distinct families."
      Tam N.H., Borriss R.
      Mol. Gen. Genet. 258:427-430(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-279.
      Strain: ATCC 23059 / NRRL B-14472 / W23.

    Entry informationi

    Entry nameiTYSY1_BACPZ
    AccessioniPrimary (citable) accession number: E0TVT6
    Secondary accession number(s): O30395, O30396, P42326
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3