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E0TVT6

- TYSY1_BACPZ

UniProt

E0TVT6 - TYSY1_BACPZ

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Protein

Thymidylate synthase 1

Gene

thyA1

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBSUB655816:GCOR-1872-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase 1UniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TS 1UniRule annotation
Short name:
TSase 1UniRule annotation
Alternative name(s):
Thymidylate synthase AUniRule annotation
Short name:
TS AUniRule annotation
Short name:
TSase AUniRule annotation
Gene namesi
Name:thyA1UniRule annotation
Synonyms:thyA
Ordered Locus Names:BSUW23_09080
OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Taxonomic identifieri655816 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000002233: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Thymidylate synthase 1PRO_0000403664Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257898.
KOiK00560.
OMAiTIGHAYG.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0TVT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQFDKQYNS IIKDIMNNGI SDEEFNVRTK WDSDGTPAHT LSVISKQMRF
60 70 80 90 100
DNSEVPILTT KKVAWKTAIK ELLWIWQLKS NDVTELNKMG VHIWDQWKQE
110 120 130 140 150
DGTIGHAYGF QLGKKNRNLN GEKVDQVDYL LHQLKNNPSS RRHITMLWNP
160 170 180 190 200
DELDSMALTP CVYETQWYVK QGKLHLEVRA RSNDMALGNP FNVFQYNVLQ
210 220 230 240 250
RMIAQVTGYE LGEYIFNIGD CHVYTRHIDN LKIQMEREQF EAPELWINPE
260 270
VKDFYDFTID DFKLFNYKHG DKLLFEVAV
Length:279
Mass (Da):32,890
Last modified:November 2, 2010 - v1
Checksum:i9E808B8519B9E33C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491N → S in AAC26325. (PubMed:9648749)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002183 Genomic DNA. Translation: ADM37862.1.
AF004103 Genomic DNA. Translation: AAC26325.1.
PIRiI40494.
RefSeqiWP_003221167.1. NC_014479.1.
YP_003866171.1. NC_014479.1.

Genome annotation databases

EnsemblBacteriaiADM37862; ADM37862; BSUW23_09080.
GeneIDi9722802.
KEGGibss:BSUW23_09080.
PATRICi42189751. VBIBacSub57968_1850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002183 Genomic DNA. Translation: ADM37862.1 .
AF004103 Genomic DNA. Translation: AAC26325.1 .
PIRi I40494.
RefSeqi WP_003221167.1. NC_014479.1.
YP_003866171.1. NC_014479.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM37862 ; ADM37862 ; BSUW23_09080 .
GeneIDi 9722802.
KEGGi bss:BSUW23_09080.
PATRICi 42189751. VBIBacSub57968_1850.

Phylogenomic databases

HOGENOMi HOG000257898.
KOi K00560.
OMAi TIGHAYG.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci BSUB655816:GCOR-1872-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
    Zeigler D.R.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23059 / NRRL B-14472 / W23.
  2. "Genes encoding thymidylate synthases A and B in the genus Bacillus are members of two distinct families."
    Tam N.H., Borriss R.
    Mol. Gen. Genet. 258:427-430(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-279.
    Strain: ATCC 23059 / NRRL B-14472 / W23.

Entry informationi

Entry nameiTYSY1_BACPZ
AccessioniPrimary (citable) accession number: E0TVT6
Secondary accession number(s): O30395, O30396, P42326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3