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Protein

Alanine racemase

Gene

alrB

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alrB), Alanine racemase (alrA)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Active sitei272Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei320Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrBImported
Ordered Locus Names:BSUW23_09050Imported
OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)Imported
Taxonomic identifieri655816 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000002233 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliE0TVT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 379Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWRGPILL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

E0TVT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLCREVWI EVNLDAIKKN LRAIRRHIPH KSKIMAVVKA NGYGHGSVEV
60 70 80 90 100
ARHALEHGAS ELAVASVEEG IVLRKAGITA PILVLGFTSL SCVKKSAAWN
110 120 130 140 150
ITLSAFQVDW MKEANEILEK EASTDRLAIH INVDTGMGRL GVRTKKELLA
160 170 180 190 200
VVKALKASKS LRWTGIFTHF STADEADTTL TKLQHEKFIS FLSFLKNQGI
210 220 230 240 250
ELPTVHMSNT AAAIAFPEFS ADMIRLGIGL YGLYPSTYIK QLNLVKLEPA
260 270 280 290 300
LSLKARIAYV KTMRTEPRTI SYGATYIAEP DEVIATLPIG YADGYSRTLS
310 320 330 340 350
NRGFVLHRGK RVPLAGRVTM DMIMVSLGES GEGKQGDEVV IYGQQKGAEI
360 370 380 390
SVDEVAEMLN TINYEVVSTL SRRIPRFYIR DGEIFKISTP VLYV
Length:394
Mass (Da):43,554
Last modified:November 2, 2010 - v1
Checksum:i6650CB13047F0F8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002183 Genomic DNA. Translation: ADM37856.1.

Genome annotation databases

EnsemblBacteriaiADM37856; ADM37856; BSUW23_09050.
KEGGibss:BSUW23_09050.

Similar proteinsi

Entry informationi

Entry nameiE0TVT0_BACPZ
AccessioniPrimary (citable) accession number: E0TVT0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: September 27, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported