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E0TVT0

- E0TVT0_BACPZ

UniProt

E0TVT0 - E0TVT0_BACPZ

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Protein

Alanine racemase

Gene

alrB

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBSUB655816:GCOR-1866-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrBImported
Ordered Locus Names:BSUW23_09050Imported
OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)Imported
Taxonomic identifieri655816 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000002233: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE0TVT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0TVT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNLCREVWI EVNLDAIKKN LRAIRRHIPH KSKIMAVVKA NGYGHGSVEV
60 70 80 90 100
ARHALEHGAS ELAVASVEEG IVLRKAGITA PILVLGFTSL SCVKKSAAWN
110 120 130 140 150
ITLSAFQVDW MKEANEILEK EASTDRLAIH INVDTGMGRL GVRTKKELLA
160 170 180 190 200
VVKALKASKS LRWTGIFTHF STADEADTTL TKLQHEKFIS FLSFLKNQGI
210 220 230 240 250
ELPTVHMSNT AAAIAFPEFS ADMIRLGIGL YGLYPSTYIK QLNLVKLEPA
260 270 280 290 300
LSLKARIAYV KTMRTEPRTI SYGATYIAEP DEVIATLPIG YADGYSRTLS
310 320 330 340 350
NRGFVLHRGK RVPLAGRVTM DMIMVSLGES GEGKQGDEVV IYGQQKGAEI
360 370 380 390
SVDEVAEMLN TINYEVVSTL SRRIPRFYIR DGEIFKISTP VLYV
Length:394
Mass (Da):43,554
Last modified:November 2, 2010 - v1
Checksum:i6650CB13047F0F8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002183 Genomic DNA. Translation: ADM37856.1.
RefSeqiWP_003221157.1. NC_014479.1.
YP_003866165.1. NC_014479.1.

Genome annotation databases

EnsemblBacteriaiADM37856; ADM37856; BSUW23_09050.
GeneIDi9722796.
KEGGibss:BSUW23_09050.
PATRICi42189739. VBIBacSub57968_1844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002183 Genomic DNA. Translation: ADM37856.1 .
RefSeqi WP_003221157.1. NC_014479.1.
YP_003866165.1. NC_014479.1.

3D structure databases

ProteinModelPortali E0TVT0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM37856 ; ADM37856 ; BSUW23_09050 .
GeneIDi 9722796.
KEGGi bss:BSUW23_09050.
PATRICi 42189739. VBIBacSub57968_1844.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci BSUB655816:GCOR-1866-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
    Zeigler D.R.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23059 / NRRL B-14472 / W23Imported.
  2. Zeigler D.R.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: W23.

Entry informationi

Entry nameiE0TVT0_BACPZ
AccessioniPrimary (citable) accession number: E0TVT0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3