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E0TVT0

- E0TVT0_BACPZ

UniProt

E0TVT0 - E0TVT0_BACPZ

Protein

Alanine racemase

Gene

alrB

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation
    Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBSUB655816:GCOR-1866-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrBImported
    Ordered Locus Names:BSUW23_09050Imported
    OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)Imported
    Taxonomic identifieri655816 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000002233: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE0TVT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0TVT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNLCREVWI EVNLDAIKKN LRAIRRHIPH KSKIMAVVKA NGYGHGSVEV    50
    ARHALEHGAS ELAVASVEEG IVLRKAGITA PILVLGFTSL SCVKKSAAWN 100
    ITLSAFQVDW MKEANEILEK EASTDRLAIH INVDTGMGRL GVRTKKELLA 150
    VVKALKASKS LRWTGIFTHF STADEADTTL TKLQHEKFIS FLSFLKNQGI 200
    ELPTVHMSNT AAAIAFPEFS ADMIRLGIGL YGLYPSTYIK QLNLVKLEPA 250
    LSLKARIAYV KTMRTEPRTI SYGATYIAEP DEVIATLPIG YADGYSRTLS 300
    NRGFVLHRGK RVPLAGRVTM DMIMVSLGES GEGKQGDEVV IYGQQKGAEI 350
    SVDEVAEMLN TINYEVVSTL SRRIPRFYIR DGEIFKISTP VLYV 394
    Length:394
    Mass (Da):43,554
    Last modified:November 2, 2010 - v1
    Checksum:i6650CB13047F0F8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM37856.1.
    RefSeqiYP_003866165.1. NC_014479.1.

    Genome annotation databases

    EnsemblBacteriaiADM37856; ADM37856; BSUW23_09050.
    GeneIDi9722796.
    KEGGibss:BSUW23_09050.
    PATRICi42189739. VBIBacSub57968_1844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002183 Genomic DNA. Translation: ADM37856.1 .
    RefSeqi YP_003866165.1. NC_014479.1.

    3D structure databases

    ProteinModelPortali E0TVT0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM37856 ; ADM37856 ; BSUW23_09050 .
    GeneIDi 9722796.
    KEGGi bss:BSUW23_09050.
    PATRICi 42189739. VBIBacSub57968_1844.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci BSUB655816:GCOR-1866-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
      Zeigler D.R.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23059 / NRRL B-14472 / W23Imported.
    2. Zeigler D.R.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: W23.

    Entry informationi

    Entry nameiE0TVT0_BACPZ
    AccessioniPrimary (citable) accession number: E0TVT0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3