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E0TVB7 (E0TVB7_BACPZ) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405

EC=3.6.1.19 HAMAP-Rule MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405
Gene names
Name:ysnA EMBL ADM38788.1
Ordered Locus Names:BSUW23_13755 EMBL ADM38788.1
OrganismBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) [Complete proteome] [HAMAP] EMBL ADM38788.1
Taxonomic identifier655816 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405 SAAS SAAS002637

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP-Rule MF_01405 SAAS SAAS002637

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405 SAAS SAAS002637

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP-Rule MF_01405 RuleBase RU003781

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP-Rule MF_01405
Region70 – 712Substrate binding By similarity HAMAP-Rule MF_01405

Sites

Metal binding411Magnesium or manganese By similarity HAMAP-Rule MF_01405
Metal binding701Magnesium or manganese By similarity HAMAP-Rule MF_01405
Binding site1561Substrate By similarity HAMAP-Rule MF_01405
Binding site1761Substrate By similarity HAMAP-Rule MF_01405
Binding site1821Substrate By similarity HAMAP-Rule MF_01405

Sequences

Sequence LengthMass (Da)Tools
E0TVB7 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 7DD5262967661496

FASTA19521,470
        10         20         30         40         50         60 
MKEAIIATHN PGKVKEFKEI LEPKGYDVKS LAEIGFTEEI EETGHTFEEN AILKAQAVAK 

        70         80         90        100        110        120 
AVNKMVIADD SGLSIDNLGG RPGVYSARYA GEQKDDQANI AKVLSELKGI EKEQRTARFR 

       130        140        150        160        170        180 
CALAVSIPGE ETKTVEGHVE GYIAEEPRGE YGFGYDPIFI VKDKDKTMAE LTSDEKNKIS 

       190 
HRADALKKLS KLLEA 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
Zeigler D.R.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23059 / NRRL B-14472 / W23.
[2]Zeigler D.R.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: W23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002183 Genomic DNA. Translation: ADM38788.1.
RefSeqYP_003867097.1. NC_014479.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADM38788; ADM38788; BSUW23_13755.
GeneID9723734.
KEGGbss:BSUW23_13755.
PATRIC42191656. VBIBacSub57968_2800.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000293319.
KOK02428.
OMAGEAHNDA.

Enzyme and pathway databases

BioCycBSUB655816:GCOR-2804-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE0TVB7_BACPZ
AccessionPrimary (citable) accession number: E0TVB7
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)