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E0TVB7

- E0TVB7_BACPZ

UniProt

E0TVB7 - E0TVB7_BACPZ

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Protein

Non-canonical purine NTP pyrophosphatase

Gene

ysnA

Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Magnesium or manganeseUniRule annotation
Metal bindingi70 – 701Magnesium or manganeseUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Binding sitei176 – 1761SubstrateUniRule annotation
Binding sitei182 – 1821SubstrateUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Nucleotide metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBSUB655816:GCOR-2804-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotationSAAS annotation (EC:3.6.1.19UniRule annotationSAAS annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Gene namesi
Name:ysnAImported
Ordered Locus Names:BSUW23_13755Imported
OrganismiBacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)Imported
Taxonomic identifieri655816 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000002233: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 136Substrate bindingUniRule annotation
Regioni70 – 712Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000293319.
KOiK02428.
OMAiEAIIATH.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

E0TVB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEAIIATHN PGKVKEFKEI LEPKGYDVKS LAEIGFTEEI EETGHTFEEN
60 70 80 90 100
AILKAQAVAK AVNKMVIADD SGLSIDNLGG RPGVYSARYA GEQKDDQANI
110 120 130 140 150
AKVLSELKGI EKEQRTARFR CALAVSIPGE ETKTVEGHVE GYIAEEPRGE
160 170 180 190
YGFGYDPIFI VKDKDKTMAE LTSDEKNKIS HRADALKKLS KLLEA
Length:195
Mass (Da):21,470
Last modified:November 2, 2010 - v1
Checksum:i7DD5262967661496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002183 Genomic DNA. Translation: ADM38788.1.
RefSeqiWP_003222529.1. NC_014479.1.
YP_003867097.1. NC_014479.1.

Genome annotation databases

EnsemblBacteriaiADM38788; ADM38788; BSUW23_13755.
GeneIDi9723734.
KEGGibss:BSUW23_13755.
PATRICi42191656. VBIBacSub57968_2800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002183 Genomic DNA. Translation: ADM38788.1 .
RefSeqi WP_003222529.1. NC_014479.1.
YP_003867097.1. NC_014479.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM38788 ; ADM38788 ; BSUW23_13755 .
GeneIDi 9723734.
KEGGi bss:BSUW23_13755.
PATRICi 42191656. VBIBacSub57968_2800.

Phylogenomic databases

HOGENOMi HOG000293319.
KOi K02428.
OMAi EAIIATH.

Enzyme and pathway databases

BioCyci BSUB655816:GCOR-2804-MONOMER.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Bacillus subtilis subsp. spizizenii str. W23."
    Zeigler D.R.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23059 / NRRL B-14472 / W23Imported.
  2. Zeigler D.R.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: W23.

Entry informationi

Entry nameiE0TVB7_BACPZ
AccessioniPrimary (citable) accession number: E0TVB7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3