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E0TSD3 (E0TSD3_STRZ6) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:SP670_1758 EMBL ADM91812.1
OrganismStreptococcus pneumoniae (strain 670-6B) [Complete proteome] [HAMAP] EMBL ADM91812.1
Taxonomic identifier189423 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain131 – 333203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding161 – 21656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2871Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3001Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3001Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3021Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E0TSD3 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 57FABB2162FDB161

FASTA34738,784
        10         20         30         40         50         60 
MKQTIILLYG GRSAEREVSV LSAESVMRAV NYDRFTVKTF FISQSGDFIK TQEFSQTPGQ 

        70         80         90        100        110        120 
EDRLMTNATI DWDKKVAPSA IYEEEAVVFP VLHGPMGEDG SVQGFLEVLK MPYVGCNILS 

       130        140        150        160        170        180 
SSLAMDKITT KRVLESTGIA QVPYVAIVEG DDVTAKIAEV EEKLTYPVFT KPSNMGSSVG 

       190        200        210        220        230        240 
ISKSENQEEL RQALKLAFQY DSRVLVEQGV NAREIEVGLL GNYDVKSTLP GEVVKDVAFY 

       250        260        270        280        290        300 
DYDAKYIDNK ITMDIPAKIS DDVVAVMRQN AETAFRAIGG LGLSRCDFFY TDKGEIFLNE 

       310        320        330        340 
LNTMPGFTQW SMYPLLWDNM GISYPELIER LVDLAKESFD KREAHLI 

« Hide

References

[1]"Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species."
Neuendorf B., Radune D., Fedorova N.B., Khouri H.M., Dodson R.J., Daugherty S.C., Hollingshead S., Tettelin H.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 670-6B EMBL ADM91812.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002176 Genomic DNA. Translation: ADM91812.1.
RefSeqYP_003879912.1. NC_014498.1.

3D structure databases

ProteinModelPortalE0TSD3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADM91812; ADM91812; SP670_1758.
GeneID9730472.
KEGGsnb:SP670_1758.
PATRIC42517760. VBIStrPne54539_1860.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

BioCycSPNE189423:GHX7-1752-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE0TSD3_STRZ6
AccessionPrimary (citable) accession number: E0TSD3
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: February 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)