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E0TR18

- E0TR18_STRZ6

UniProt

E0TR18 - E0TR18_STRZ6

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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Streptococcus pneumoniae (strain 670-6B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu-and -Tyr-|-Trp bonds also occurs).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961NucleophileUniRule annotation
Active sitei121 – 1211UniRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BioCyciSPNE189423:GHX7-1572-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase ClpUniRule annotation
Gene namesi
Name:clpPUniRule annotationImported
Ordered Locus Names:SP670_1577Imported
OrganismiStreptococcus pneumoniae (strain 670-6B)Imported
Taxonomic identifieri189423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002232: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE0TR18.
SMRiE0TR18. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000285833.
KOiK01358.
OMAiEIMANNQ.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0TR18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPVVIEQTS RGERSYDIYS RLLKDRIIML TGPVEDNMAN SVIAQLLFLD
60 70 80 90 100
AQDSTKDIYL YVNTPGGSVS AGLAIVDTMN FIKADVQTIV MGMAASMGTV
110 120 130 140 150
IASSGAKGKR FMLPNAEYMI HQPMGGTGGG TQQTDMAIAA EHLLKTRNTL
160 170 180 190
EKILAENSGQ SMEKVHADAE RDNWMSAQET LEYGFIDEIM ANNSLN
Length:196
Mass (Da):21,358
Last modified:November 2, 2010 - v1
Checksum:i2C6C3A820A290B2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002176 Genomic DNA. Translation: ADM91633.1.
RefSeqiYP_003879733.1. NC_014498.1.

Genome annotation databases

EnsemblBacteriaiADM91633; ADM91633; SP670_1577.
GeneIDi9730292.
KEGGisnb:SP670_1577.
PATRICi42517365. VBIStrPne54539_1666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002176 Genomic DNA. Translation: ADM91633.1 .
RefSeqi YP_003879733.1. NC_014498.1.

3D structure databases

ProteinModelPortali E0TR18.
SMRi E0TR18. Positions 1-194.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM91633 ; ADM91633 ; SP670_1577 .
GeneIDi 9730292.
KEGGi snb:SP670_1577.
PATRICi 42517365. VBIStrPne54539_1666.

Phylogenomic databases

HOGENOMi HOG000285833.
KOi K01358.
OMAi EIMANNQ.

Enzyme and pathway databases

BioCyci SPNE189423:GHX7-1572-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species."
    Neuendorf B., Radune D., Fedorova N.B., Khouri H.M., Dodson R.J., Daugherty S.C., Hollingshead S., Tettelin H.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 670-6BImported.

Entry informationi

Entry nameiE0TR18_STRZ6
AccessioniPrimary (citable) accession number: E0TR18
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3