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E0TR18

- E0TR18_STRZ6

UniProt

E0TR18 - E0TR18_STRZ6

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Protein
ATP-dependent Clp protease proteolytic subunit
Gene
clpP, SP670_1577
Organism
Streptococcus pneumoniae (strain 670-6B)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu-and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Nucleophile By similarityUniRule annotation
Active sitei121 – 1211 By similarityUniRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BioCyciSPNE189423:GHX7-1572-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp
Gene namesi
Name:clpPUniRule annotationImported
Ordered Locus Names:SP670_1577Imported
OrganismiStreptococcus pneumoniae (strain 670-6B)Imported
Taxonomic identifieri189423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002232: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE0TR18.
SMRiE0TR18. Positions 1-194.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000285833.
KOiK01358.
OMAiEIMANNQ.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0TR18-1 [UniParc]FASTAAdd to Basket

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MIPVVIEQTS RGERSYDIYS RLLKDRIIML TGPVEDNMAN SVIAQLLFLD    50
AQDSTKDIYL YVNTPGGSVS AGLAIVDTMN FIKADVQTIV MGMAASMGTV 100
IASSGAKGKR FMLPNAEYMI HQPMGGTGGG TQQTDMAIAA EHLLKTRNTL 150
EKILAENSGQ SMEKVHADAE RDNWMSAQET LEYGFIDEIM ANNSLN 196
Length:196
Mass (Da):21,358
Last modified:November 2, 2010 - v1
Checksum:i2C6C3A820A290B2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002176 Genomic DNA. Translation: ADM91633.1.
RefSeqiYP_003879733.1. NC_014498.1.

Genome annotation databases

EnsemblBacteriaiADM91633; ADM91633; SP670_1577.
GeneIDi9730292.
KEGGisnb:SP670_1577.
PATRICi42517365. VBIStrPne54539_1666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002176 Genomic DNA. Translation: ADM91633.1 .
RefSeqi YP_003879733.1. NC_014498.1.

3D structure databases

ProteinModelPortali E0TR18.
SMRi E0TR18. Positions 1-194.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM91633 ; ADM91633 ; SP670_1577 .
GeneIDi 9730292.
KEGGi snb:SP670_1577.
PATRICi 42517365. VBIStrPne54539_1666.

Phylogenomic databases

HOGENOMi HOG000285833.
KOi K01358.
OMAi EIMANNQ.

Enzyme and pathway databases

BioCyci SPNE189423:GHX7-1572-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species."
    Neuendorf B., Radune D., Fedorova N.B., Khouri H.M., Dodson R.J., Daugherty S.C., Hollingshead S., Tettelin H.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 670-6BImported.

Entry informationi

Entry nameiE0TR18_STRZ6
AccessioniPrimary (citable) accession number: E0TR18
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi