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E0TNK5

- E0TNK5_STRZ6

UniProt

E0TNK5 - E0TNK5_STRZ6

Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus pneumoniae (strain 670-6B)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton acceptorUniRule annotation
    Metal bindingi143 – 1431ZincUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi85 – 884ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSPNE189423:GHX7-1297-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:SP670_1302Imported
    OrganismiStreptococcus pneumoniae (strain 670-6B)Imported
    Taxonomic identifieri189423 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002232: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE0TNK5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiAIPITAD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0TNK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLYYRYGT MNSGKTIEIL KVAYNYEEQG KGVVIMTSAL DTRDGVGYVS    50
    SRIGMKRPAL AIEETTDIFG YIRDLPEKPY CVLVDEAQFL KRHHVYDLAR 100
    VVDELDIPVM AFGLKNDFRN ELFEGSKYLL LLADKIDEIK TICQYCKKKA 150
    TMVLRTQDGL PVYDGEQIQI GGNETYISVC RKHYFAPEIN KENEEK 196
    Length:196
    Mass (Da):22,502
    Last modified:November 2, 2010 - v1
    Checksum:i02AFF959FC583067
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002176 Genomic DNA. Translation: ADM91363.1.
    RefSeqiYP_003879463.1. NC_014498.1.

    Genome annotation databases

    EnsemblBacteriaiADM91363; ADM91363; SP670_1302.
    GeneIDi9730020.
    KEGGisnb:SP670_1302.
    PATRICi42516763. VBIStrPne54539_1370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002176 Genomic DNA. Translation: ADM91363.1 .
    RefSeqi YP_003879463.1. NC_014498.1.

    3D structure databases

    ProteinModelPortali E0TNK5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM91363 ; ADM91363 ; SP670_1302 .
    GeneIDi 9730020.
    KEGGi snb:SP670_1302.
    PATRICi 42516763. VBIStrPne54539_1370.

    Phylogenomic databases

    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi AIPITAD.

    Enzyme and pathway databases

    BioCyci SPNE189423:GHX7-1297-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species."
      Neuendorf B., Radune D., Fedorova N.B., Khouri H.M., Dodson R.J., Daugherty S.C., Hollingshead S., Tettelin H.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 670-6BImported.

    Entry informationi

    Entry nameiE0TNK5_STRZ6
    AccessioniPrimary (citable) accession number: E0TNK5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3