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E0TNH4

- E0TNH4_STRZ6

UniProt

E0TNH4 - E0TNH4_STRZ6

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus pneumoniae (strain 670-6B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381UniRule annotation
    Active sitei561 – 5611UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, PyruvateImported

    Enzyme and pathway databases

    BioCyciSPNE189423:GHX7-1266-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotationImported
    Ordered Locus Names:SP670_1271Imported
    OrganismiStreptococcus pneumoniae (strain 670-6B)Imported
    Taxonomic identifieri189423 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002232: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000238647.
    KOiK01595.
    OMAiSILNCET.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0TNH4-1 [UniParc]FASTAAdd to Basket

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    MSLQKLENYS NKSVVQEEVL ILTELLEDIT KNMLAPETFE KIIQLKELST    50
    QEDYQGLNRL VTSLSNDEMV YISRYFSILP LLINISEDVD LAYEINHQNN 100
    IDQDYLGKLS TTIKLVAEKE NAVEILEHLN VVPVLTAHPT QVQRKSMLDL 150
    TNHIHSLLRK YRDVKLGLIN KDKWYNDLRR YIEIIMQTDM IREKKLKVTN 200
    EITNAMEYYN SSFLKAVPHL TTEYKRLAQA HGLNLKQAKP ITMGMWIGGD 250
    RDGNPFVTAK TLKQSALTQC EVIMNYYDKK IYQLYREFSL STSIVNVSKQ 300
    VREMARQSKD NSIYREKELY RRALFDIQSK IQATKTYLIE DEEVGTRYET 350
    ANDFYKDLIA IRDSLLENKG ESLISGDFVE LLQAVEIFGF YLASIDMRQD 400
    SSVYEACVAE LLKSAGIHSR YSELSEEEKC DLLLKELEED PRILSATHAE 450
    KSELLAKELA IFKTARVLKD KLGDDVIRQT IISHATSLSD MLELAILLKE 500
    VGLVDTERAR VQIVPLFETI EDLDHSEETM RKYLSLSLAK KWIDSRNNYQ 550
    EIMLGYSDSN KDGGYLSSCW TLYKAQQQLT AIGDEFGVKV TFFHGRGGTV 600
    GRGGGPTYEA ITSQPLKSIK DRIRLTEQGE VIGNKYGNKD AAYYNLEMLV 650
    SAAINRMITQ KKSDTNTPNR YEAIMDQVVD RSYDVYRDLV FGNEHFYDYF 700
    FESSPIKAIS SFNIGSRPAA RKTITEIGGL RAIPWVFSWS QSRVMFPGWY 750
    GVGSSFKEFI NKNPENIAIL RDMYQNWPFF QSLLSNVDMV LSKSNMNIAF 800
    EYAKLCEDEQ VKAIYETILN EWQVTKNVIL AIEGHDELLA DNPYLKASLD 850
    YRMPYFNILN YIQLELIKRQ RRGELSSDQE RLIHITINGI ATGLRNSG 898
    Length:898
    Mass (Da):103,271
    Last modified:November 2, 2010 - v1
    Checksum:iF7FD1F552BF04E62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002176 Genomic DNA. Translation: ADM91332.1.
    RefSeqiYP_003879432.1. NC_014498.1.

    Genome annotation databases

    EnsemblBacteriaiADM91332; ADM91332; SP670_1271.
    GeneIDi9729989.
    KEGGisnb:SP670_1271.
    PATRICi42516697. VBIStrPne54539_1337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002176 Genomic DNA. Translation: ADM91332.1 .
    RefSeqi YP_003879432.1. NC_014498.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM91332 ; ADM91332 ; SP670_1271 .
    GeneIDi 9729989.
    KEGGi snb:SP670_1271.
    PATRICi 42516697. VBIStrPne54539_1337.

    Phylogenomic databases

    HOGENOMi HOG000238647.
    KOi K01595.
    OMAi SILNCET.

    Enzyme and pathway databases

    BioCyci SPNE189423:GHX7-1266-MONOMER.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species."
      Neuendorf B., Radune D., Fedorova N.B., Khouri H.M., Dodson R.J., Daugherty S.C., Hollingshead S., Tettelin H.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 670-6BImported.

    Entry informationi

    Entry nameiE0TNH4_STRZ6
    AccessioniPrimary (citable) accession number: E0TNH4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3