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Protein

Riboflavin biosynthesis protein

Gene

ribF

Organism
Streptococcus pneumoniae (strain 670-6B)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + FMN = diphosphate + FAD.UniRule annotation
ATP + riboflavin = ADP + FMN.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. FMN adenylyltransferase activity Source: UniProtKB-EC
  3. riboflavin kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. FAD biosynthetic process Source: UniProtKB-UniPathway
  2. FMN biosynthetic process Source: UniProtKB-UniPathway
  3. riboflavin biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, NucleotidyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE189423:GHX7-1224-MONOMER.
UniPathwayiUPA00276; UER00406.
UPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis proteinUniRule annotation (EC:2.7.1.26UniRule annotation, EC:2.7.7.2UniRule annotation)
Gene namesi
Name:ribFImported
Ordered Locus Names:SP670_1229Imported
OrganismiStreptococcus pneumoniae (strain 670-6B)Imported
Taxonomic identifieri189423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002232 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE0TN91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000006844.
KOiK11753.
OMAiIDRLLCV.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR015864. FAD_synthase.
IPR023468. Riboflavin_kinase.
IPR002606. Riboflavin_kinase_bac.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF06574. FAD_syn. 1 hit.
PF01687. Flavokinase. 1 hit.
[Graphical view]
PIRSFiPIRSF004491. FAD_Synth. 1 hit.
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.
TIGRFAMsiTIGR00083. ribF. 1 hit.

Sequencei

Sequence statusi: Complete.

E0TN91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIITIPIKNQ KDIGTPSDSV VVLGYFDGIH KGHQELFRVA NKAARKDLLP
60 70 80 90 100
IVVMTFNESP KIALEPYHPD LFLHILNPAE RERKLKREGV EELYLLDFSS
110 120 130 140 150
QFASLTAQEF FATYIKAMNA KIIVAGFDYT FGSDKKTAED LKDYFDGEVI
160 170 180 190 200
IVPPVEDEKG KISSTRIRQA ILDGNVKEAG KLLGAPLPSR GMVVHGNARG
210 220 230 240 250
RTIGYPTANL VLLDRTYMPA DGVYVVDVEI QRQKYRAMAS VGKNVTFDGE
260 270 280 290 300
EARFEVNIFD FNQDIYGETV MVYWLDRIRD MTKFDSVDQL VDQLKADEEV

TRNWS
Length:305
Mass (Da):34,522
Last modified:November 1, 2010 - v1
Checksum:i93968AA4724556C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002176 Genomic DNA. Translation: ADM91290.1.
RefSeqiYP_003879390.1. NC_014498.1.

Genome annotation databases

EnsemblBacteriaiADM91290; ADM91290; SP670_1229.
KEGGisnb:SP670_1229.
PATRICi42516608. VBIStrPne54539_1293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002176 Genomic DNA. Translation: ADM91290.1.
RefSeqiYP_003879390.1. NC_014498.1.

3D structure databases

ProteinModelPortaliE0TN91.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADM91290; ADM91290; SP670_1229.
KEGGisnb:SP670_1229.
PATRICi42516608. VBIStrPne54539_1293.

Phylogenomic databases

HOGENOMiHOG000006844.
KOiK11753.
OMAiIDRLLCV.

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406.
UPA00277; UER00407.
BioCyciSPNE189423:GHX7-1224-MONOMER.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR015864. FAD_synthase.
IPR023468. Riboflavin_kinase.
IPR002606. Riboflavin_kinase_bac.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF06574. FAD_syn. 1 hit.
PF01687. Flavokinase. 1 hit.
[Graphical view]
PIRSFiPIRSF004491. FAD_Synth. 1 hit.
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.
TIGRFAMsiTIGR00083. ribF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species."
    Neuendorf B., Radune D., Fedorova N.B., Khouri H.M., Dodson R.J., Daugherty S.C., Hollingshead S., Tettelin H.
    Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 670-6BImported.

Entry informationi

Entry nameiE0TN91_STRZ6
AccessioniPrimary (citable) accession number: E0TN91
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 2010
Last sequence update: November 1, 2010
Last modified: March 31, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.