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E0TAP2 (E0TAP2_EDWTF) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:ETAF_3055 EMBL ADM43158.1
OrganismEdwardsiella tarda (strain FL6-60) [Complete proteome] [HAMAP] EMBL ADM43158.1
Taxonomic identifier718251 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEdwardsiella

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain145 – 348204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding175 – 23056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3021Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3171Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E0TAP2 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 7CFD230A99996A24

FASTA36740,063
        10         20         30         40         50         60 
MAKIRVGIVF GGQSCEHEVS LQSAKNIVEA IDQSRFDVTL IGIDKQGYWH LCGGQDYLNH 

        70         80         90        100        110        120 
AQDPQHIALN HSERRLAVIP GATQGQLIDS ASGEPLPSLD VIFPIVHGTQ GEDGCLQGML 

       130        140        150        160        170        180 
KMLNLPFVGS DVIGSAACMD KEVCKRLLRD AGLPITPFVT LTRATQANYD YETLRSQLGE 

       190        200        210        220        230        240 
TLFVKPANQG SSVGVSKVRN ADEYHRAIAD ALRFDHKVIV ERGVVGREIE CAILGNEAAQ 

       250        260        270        280        290        300 
ASVCGEIVLH SDFYSYDSKY ISAQGAQVVV PAAMAPEASE RVRHTALRAF QALECRGLAR 

       310        320        330        340        350        360 
VDVFLTEDNE VIINEINTLP GFTNISMYPK LWQASGIGYQ ALITRLIELA LERHRLDSQL 


CRATGSC 

« Hide

References

[1]"Genome comparisons of Edwardsiella bacteria analysed using deep sequencing technology."
van Soest J.J., Henkel C.V., Jansen H.J., van den Hondel C.A.M.J.J., Bloemberg G.V., Meijer A.H., Spaink H.P.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FL6-60.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002154 Genomic DNA. Translation: ADM43158.1.
RefSeqYP_005700650.1. NC_017309.1.

3D structure databases

ProteinModelPortalE0TAP2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADM43158; ADM43158; ETAF_3055.
GeneID12860358.
KEGGetd:ETAF_3055.
PATRIC42920968. VBIEdwTar147555_3186.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

BioCycETAR718251:GLCN-3153-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE0TAP2_EDWTF
AccessionPrimary (citable) accession number: E0TAP2
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)