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E0SRG9

- E0SRG9_IGNAA

UniProt

E0SRG9 - E0SRG9_IGNAA

Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei163 – 1631Proton acceptorUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Metal bindingi189 – 1891Magnesium; via carbamate groupUniRule annotation
    Metal bindingi191 – 1911MagnesiumUniRule annotation
    Metal bindingi192 – 1921MagnesiumUniRule annotation
    Active sitei281 – 2811Proton acceptorUniRule annotation
    Binding sitei282 – 2821SubstrateUniRule annotation
    Binding sitei314 – 3141SubstrateUniRule annotation
    Sitei322 – 3221Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. carbon fixation Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciIAGG583356:GHAH-1667-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCOUniRule annotation
    Gene namesi
    Name:rbcLUniRule annotation
    Ordered Locus Names:Igag_1625Imported
    OrganismiIgnisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)Imported
    Taxonomic identifieri583356 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnisphaera
    ProteomesiUP000001304: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei189 – 1891N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE0SRG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni367 – 3693Substrate bindingUniRule annotation
    Regioni389 – 3924Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family.UniRule annotation
    Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000230831.
    KOiK01601.
    OMAiIFRESHY.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProiIPR017712. RuBisCO_III.
    IPR020878. RuBisCo_large_chain_AS.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
    PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0SRG9-1 [UniParc]FASTAAdd to Basket

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    MSKPDFEPYS AWVEKSYTPD PKSDVIVTFR ITPAEGFTIE DVAGGVAAES    50
    STGTWTTLYP WYDENRLRRL RGKAYAFKDL GDGSYLVRIA YPVELFEEGN 100
    MPVFLASVAG NIFGMRRAKY LRVEDIYMPY DFIKYFKGPV KGIQGVRDTL 150
    KVYDRPIVGT VPKPKVGYTA DEVEKLAYEI LSGGMDFIKD DENLGGPSYC 200
    RFEARAKAIM KIIDKVEKET GERKVWLANI TADVREMEKR LKLVADYGNP 250
    VIMVDVVIVG WASLGYIRDL AEEYKLYIHA HRAMHAAITR NPYHGISMFT 300
    LAKLFRIIGV DQLHIGTPEV GKLEARTIDV IRNAKVLREN PFKPDKDDDF 350
    HLEQEFYHIK PALPTSSGGL HPGTLPEVVR VMGKDLVIQV GGGTIGHPDG 400
    PRAGAMAVRQ ALEAIAKGIP LDEYAKDHKE LRRALEKWGY VKPI 444
    Length:444
    Mass (Da):49,904
    Last modified:November 2, 2010 - v1
    Checksum:iF7A8190E2F7FE850
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002098 Genomic DNA. Translation: ADM28423.1.
    RefSeqiYP_003860303.1. NC_014471.1.

    Genome annotation databases

    EnsemblBacteriaiADM28423; ADM28423; Igag_1625.
    GeneIDi9716941.
    KEGGiiag:Igag_1625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002098 Genomic DNA. Translation: ADM28423.1 .
    RefSeqi YP_003860303.1. NC_014471.1.

    3D structure databases

    ProteinModelPortali E0SRG9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM28423 ; ADM28423 ; Igag_1625 .
    GeneIDi 9716941.
    KEGGi iag:Igag_1625.

    Phylogenomic databases

    HOGENOMi HOG000230831.
    KOi K01601.
    OMAi IFRESHY.

    Enzyme and pathway databases

    BioCyci IAGG583356:GHAH-1667-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProi IPR017712. RuBisCO_III.
    IPR020878. RuBisCo_large_chain_AS.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
    PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17230 / JCM 13409 / AQ1.S1Imported.

    Entry informationi

    Entry nameiE0SRG9_IGNAA
    AccessioniPrimary (citable) accession number: E0SRG9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3