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E0SQN9 (E0SQN9_IGNAA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420

EC=6.3.5.3 HAMAP-Rule MF_00420
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP-Rule MF_00420
Gene names
Name:purL HAMAP-Rule MF_00420
Ordered Locus Names:Igag_0264 EMBL ADM27113.1
OrganismIgnisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1) [Complete proteome] [HAMAP] EMBL ADM27113.1
Taxonomic identifier583356 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnisphaera

Protein attributes

Sequence length731 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00420

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00420.

Sequence similarities

Belongs to the FGAMS family. HAMAP-Rule MF_00420

Ontologies

Keywords
   Biological processPurine biosynthesis HAMAP-Rule MF_00420
   Cellular componentCytoplasm HAMAP-Rule MF_00420
   LigandATP-binding HAMAP-Rule MF_00420
Nucleotide-binding
   Molecular functionLigase HAMAP-Rule MF_00420 EMBL ADM27113.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding91 – 10212ATP By similarity HAMAP-Rule MF_00420

Sequences

Sequence LengthMass (Da)Tools
E0SQN9 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 5B2D021AB497EA0B

FASTA73180,109
        10         20         30         40         50         60 
MPLTNDEIEE IKRILGREPT VEELAMFEAQ WSEHCSYKSS RLLLRLLPTK AKHVVLGPGR 

        70         80         90        100        110        120 
DAPAVEVFPD VLVVFKIESH NHPSAVDPYN GAATGIGGIV RDILTLGAKP IALLDLLYMG 

       130        140        150        160        170        180 
NPRDPHANWL IRGIVKGISD YGNRIGIPTV AGDTWFDEAF NKQPLVNVAC VGIVSPDKAV 

       190        200        210        220        230        240 
LSGPKSGDLI LIIGNATGRD GLLGSSFASR PLAEDVDKDI GAVQVGDPLT EKLLIDVIQI 

       250        260        270        280        290        300 
LVEKNLVNYI KDLGGGGLTT ALSESAADHG LGAVIYLDKL HTRQSLTPLE LLVSESQERM 

       310        320        330        340        350        360 
LLAVPPTKIE DVKNILEGYE VPYSIIGYFD DSGIIKVFYM DRKVVEAPAK ELAKPRAIRR 

       370        380        390        400        410        420 
PSKPPTEALK GFEPIILPDT EIDIEKTILL LLSSPNIASK KWIYEQYDHE VGARTIIKPG 

       430        440        450        460        470        480 
YGDAAVLRLL DGSRRGIAVK GDANPRYTYL DPFNGAANVV SECYRNLTAV GSTPLAIVDE 

       490        500        510        520        530        540 
LNAGNPEKPE HYWYFEEMLK GLAWISDELG LPIVGGKVSF YNEDSRGVQV KPTLTVVGVG 

       550        560        570        580        590        600 
RIDDISYARG MGFREYGSYI VVIGTTYPEI GGTEYLYRVH GIEHGEIPKP RPTYEISHGN 

       610        620        630        640        650        660 
IVRRLIHRDI ALSVHDIGLG GLGIALIEMA IVSGIGFDVD LSVIPMRAVD RLDVLLFSET 

       670        680        690        700        710        720 
QARYIIEIDG RRLDEAKKIL DESSVVYSVI GVTKGYEKTV FRYNGNVVAS IDLINAVDIY 

       730 
MNSLERELEV V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002098 Genomic DNA. Translation: ADM27113.1.
RefSeqYP_003858993.1. NC_014471.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADM27113; ADM27113; Igag_0264.
GeneID9715580.
KEGGiag:Igag_0264.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000238227.
KOK01952.
OMADHMVGTD.

Enzyme and pathway databases

BioCycIAGG583356:GHAH-279-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

Gene3D3.30.1330.10. 2 hits.
HAMAPMF_00420. PurL_2.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE0SQN9_IGNAA
AccessionPrimary (citable) accession number: E0SQN9
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)