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Protein

Exosome complex component Csl4

Gene

csl4

Organism
Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi151 – 1511ZincUniRule annotation
Metal bindingi154 – 1541ZincUniRule annotation
Metal bindingi167 – 1671ZincUniRule annotation
Metal bindingi170 – 1701ZincUniRule annotation

GO - Molecular functioni

  1. RNA binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciIAGG583356:GHAH-1070-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component Csl4UniRule annotation
Gene namesi
Name:csl4UniRule annotation
Ordered Locus Names:Igag_1050Imported
OrganismiIgnisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)Imported
Taxonomic identifieri583356 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnisphaera
ProteomesiUP000001304 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. exosome (RNase complex) Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, ExosomeUniRule annotation

Interactioni

Subunit structurei

Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the CSL4 family.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000222781.
KOiK07573.
OMAiCGNVETR.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00975. Exosome_Csl4.
InterProiIPR019495. EXOSC1.
IPR025721. Exosome_cplx_N_dom.
IPR030850. Exosome_Csl4_arc.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
[Graphical view]
PfamiPF14382. ECR1_N. 1 hit.
PF10447. EXOSC1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0SNR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPPNSIVL PGEKLCVEEE YMPSIGTYSE EGIVRAAIIG RVQYDIINRR
60 70 80 90 100
IYIKSIKSPV IPKAGDIVIG VVEQMRDELA TINIIGYDTN NLFKHSFTGI
110 120 130 140 150
LHISQASETR IPTLYDVIRV GDIIRAKVLN NYIPILLSIK EPRLGVIQAY
160 170 180
CSRCGSPLIK SGDKLRCSFC GNIENRKIAF DYILRGK
Length:187
Mass (Da):20,913
Last modified:November 2, 2010 - v1
Checksum:iD04A01ADCF2B0A22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002098 Genomic DNA. Translation: ADM27864.1.
RefSeqiYP_003859744.1. NC_014471.1.

Genome annotation databases

EnsemblBacteriaiADM27864; ADM27864; Igag_1050.
GeneIDi9716366.
KEGGiiag:Igag_1050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002098 Genomic DNA. Translation: ADM27864.1.
RefSeqiYP_003859744.1. NC_014471.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADM27864; ADM27864; Igag_1050.
GeneIDi9716366.
KEGGiiag:Igag_1050.

Phylogenomic databases

HOGENOMiHOG000222781.
KOiK07573.
OMAiCGNVETR.

Enzyme and pathway databases

BioCyciIAGG583356:GHAH-1070-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00975. Exosome_Csl4.
InterProiIPR019495. EXOSC1.
IPR025721. Exosome_cplx_N_dom.
IPR030850. Exosome_Csl4_arc.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
[Graphical view]
PfamiPF14382. ECR1_N. 1 hit.
PF10447. EXOSC1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17230 / JCM 13409 / AQ1.S1Imported.

Entry informationi

Entry nameiE0SNR8_IGNAA
AccessioniPrimary (citable) accession number: E0SNR8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: April 29, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.