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E0SJQ4

- E0SJQ4_DICD3

UniProt

E0SJQ4 - E0SJQ4_DICD3

Protein
Submitted name:

Gamma-aminobutyric-acid receptor subunit beta-1

Gene

Dda3937_00520

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. extracellular ligand-gated ion channel activity Source: InterPro

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    BioCyciDDAD198628:GHFQ-4244-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Gamma-aminobutyric-acid receptor subunit beta-1Imported
    Gene namesi
    Ordered Locus Names:Dda3937_00520Imported
    OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))Imported
    Taxonomic identifieri198628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
    ProteomesiUP000006859: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60036N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YN6X-ray3.31A/B/C/D/E22-343[»]
    3RQUX-ray3.09A/B/C/D/E/F/G/H/I/J22-343[»]
    3RQWX-ray2.91A/B/C/D/E/F/G/H/I/J22-343[»]
    3UQ4X-ray3.50A/B/C/D/E/F/G/H/I/J22-343[»]
    3UQ5X-ray4.20A/B/C/D/E/F/G/H/I/J22-343[»]
    3UQ7X-ray3.80A/B/C/D/E/F/G/H/I/J22-343[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000157201.
    OMAiFTYEASF.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E0SJQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILWSCCGL VLLLLGLPAW SAPADNAADA RPVDVSVSIF INKIYGVNTL    50
    EQTYKVDGYI VAQWTGKPRK TPGDKPLIVE NTQIERWINN GLWVPALEFI 100
    NVVGSPDTGN KRLMLFPDGR VIYNARFLGS FSNDMDFRLF PFDRQQFVLE 150
    LEPFSYNNQQ LRFSDIQVYT ENIDNEEIDE WWIRGKASTH ISDIRYDHLS 200
    SVQPNQNEFS RITVRIDAVR NPSYYLWSFI LPLGLIIAAS WSVFWLESFS 250
    ERLQTSFTLM LTVVAYAFYT SNILPRLPYT TVIDQMIIAG YGSIFAAILL 300
    IIFAHHRQAN GVEDDLLIQR CRLAFPLGFL AIGCVLVIRG ITL 343
    Length:343
    Mass (Da):39,175
    Last modified:November 2, 2010 - v1
    Checksum:i90663D9956C5C82E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002038 Genomic DNA. Translation: ADN00343.1.
    RefSeqiYP_003884899.1. NC_014500.1.

    Genome annotation databases

    EnsemblBacteriaiADN00343; ADN00343; Dda3937_00520.
    GeneIDi9735629.
    KEGGiddd:Dda3937_00520.
    PATRICi42320599. VBIDicDad25310_4084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002038 Genomic DNA. Translation: ADN00343.1 .
    RefSeqi YP_003884899.1. NC_014500.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YN6 X-ray 3.31 A/B/C/D/E 22-343 [» ]
    3RQU X-ray 3.09 A/B/C/D/E/F/G/H/I/J 22-343 [» ]
    3RQW X-ray 2.91 A/B/C/D/E/F/G/H/I/J 22-343 [» ]
    3UQ4 X-ray 3.50 A/B/C/D/E/F/G/H/I/J 22-343 [» ]
    3UQ5 X-ray 4.20 A/B/C/D/E/F/G/H/I/J 22-343 [» ]
    3UQ7 X-ray 3.80 A/B/C/D/E/F/G/H/I/J 22-343 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60036N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADN00343 ; ADN00343 ; Dda3937_00520 .
    GeneIDi 9735629.
    KEGGi ddd:Dda3937_00520.
    PATRICi 42320599. VBIDicDad25310_4084.

    Phylogenomic databases

    HOGENOMi HOG000157201.
    OMAi FTYEASF.

    Enzyme and pathway databases

    BioCyci DDAD198628:GHFQ-4244-MONOMER.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 3937Imported.
    2. "Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine."
      Pan J., Chen Q., Willenbring D., Yoshida K., Tillman T., Kashlan O.B., Cohen A., Kong X.P., Xu Y., Tang P.
      Nat. Commun. 3:714-714(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) OF 22-343.
    3. "Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations."
      Zimmermann I., Marabelli A., Bertozzi C., Sivilotti L.G., Dutzler R.
      PLoS Biol. 10:e1001429-e1001429(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.31 ANGSTROMS) OF 22-343.
    4. "Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals."
      Gonzalez-Gutierrez G., Lukk T., Agarwal V., Papke D., Nair S.K., Grosman C.
      Proc. Natl. Acad. Sci. U.S.A. 109:6331-6336(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 22-343.

    Entry informationi

    Entry nameiE0SJQ4_DICD3
    AccessioniPrimary (citable) accession number: E0SJQ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3