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Protein

Pyruvate kinase

Gene

pykA

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), Probable phosphoglycerate mutase GpmB (ytjC)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA), Pyruvate kinase (pykF)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciDDAD198628:G1GMV-2124-MONOMER
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pykAImported
Ordered Locus Names:Dda3937_03576Imported
OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))Imported
Taxonomic identifieri198628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeDickeya
Proteomesi
  • UP000006859 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi198628.Dda3937_03576

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 344PKInterPro annotationAdd BLAST339
Domaini363 – 477PK_CInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CA9 Bacteria
COG0469 LUCA
HOGENOMiHOG000021558
KOiK00873
OMAiICVEAEK
OrthoDBiPOG091H02AT

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

E0SB87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRLRRTKI VTTLGPATDR DNNLEKIIAA GANVVRLNFS HGSPEDHLLR
60 70 80 90 100
ANKVREIAAK LGRHVAILGD LQGPKIRVST FKEGKIFLNV GDKFLLDASL
110 120 130 140 150
GKGEGDKEKV GIDYKGLPRD VVPGDILLLD DGRVQLKVLA VDDMKVFTEV
160 170 180 190 200
TVGGPLSNNK GINKLGGGLS AEALTEKDKA DIITAAKIGV DFLAVSFPRT
210 220 230 240 250
GEDLHYARRL AREAGSNAKI VSKVERAEAV STDEAMDDII LASDIVMVAR
260 270 280 290 300
GDLGVEIGDP ELVGIQKKLI RRARQLNRAV ITATQMMESM ITNPMPTRAE
310 320 330 340 350
VMDVANAVLD GTDAVMLSAE TAAGQYPAET VAAMAKVCLG AEKIPSINVS
360 370 380 390 400
KHRLDVQFDN VEESIAMSAM YAANHLNGVT AIIAMTESGR TALMMSRISS
410 420 430 440 450
GLPIFAMSRH EHTLNLTALY RGVTPVQFTS YTDGVAAAND AVILLRDKGF
460 470 480
LVSGDLVIVT QGDVMGTVGT TNTVRVLRVE
Length:480
Mass (Da):51,434
Last modified:November 2, 2010 - v1
Checksum:i17FC66FDEFF1BECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002038 Genomic DNA Translation: ADM98356.1
RefSeqiWP_013317810.1, NC_014500.1

Genome annotation databases

EnsemblBacteriaiADM98356; ADM98356; Dda3937_03576
GeneIDi9733586
KEGGiddd:Dda3937_03576
PATRICifig|198628.6.peg.2132

Similar proteinsi

Entry informationi

Entry nameiE0SB87_DICD3
AccessioniPrimary (citable) accession number: E0SB87
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health