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E0S217

- E0S217_BUTPB

UniProt

E0S217 - E0S217_BUTPB

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, bpr_I1102
Organism
Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarity
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarity
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei325 – 3251NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarity
Nucleotide bindingi307 – 3126NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPRO515622:GHKV-1125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:bpr_I1102Imported
OrganismiButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)Imported
Taxonomic identifieri515622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
ProteomesiUP000001299: Chromosome 1

PTM / Processingi

Proteomic databases

PRIDEiE0S217.

Structurei

3D structure databases

ProteinModelPortaliE0S217.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiCVNTVET.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0S217-1 [UniParc]FASTAAdd to Basket

« Hide

MGKIQMTTPI VEMDGDEMTR VLWQLIKDKL ILPYVDLKSE YYDLGLKHRD    50
ETDDQVTVDS ANATLKYGVA VKCATITPND ERVKEYSLKK MYKSPNGTIR 100
AILDGTVFRT PIMVKGIEPN VRTWESPITL ARHAYGDVYK NVEIRVPGPG 150
KAELVFTGAD GTEIRETIHE FTEPGIIQGM HNKDASIESF ARACFKYALS 200
EKKELWLGTK DTISKTYDRR FRDIFDEIYE KEFKEDFEKA GITYFYTLID 250
DAVARVMKSK GGFIWACKNY DGDVMSDMVS SAFGSLAMMT SVLVSPSGVY 300
EYEAAHGTVQ RHYYKYLKGE PTSTNPVATI FAWTGALRKR GELDNIKELM 350
EFADKLEKAT LSVIESGRMT GDLALITSLP NPVKLGSEEF LDAIAAELET 400
I 401
Length:401
Mass (Da):45,140
Last modified:November 2, 2010 - v1
Checksum:iC3CC04E8089EC291
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001810 Genomic DNA. Translation: ADL33842.1.
RefSeqiWP_013280498.1. NC_014387.1.
YP_003830424.1. NC_014387.1.

Genome annotation databases

EnsemblBacteriaiADL33842; ADL33842; bpr_I1102.
GeneIDi9574755.
KEGGibpb:bpr_I1102.
PATRICi42221475. VBIButPro41874_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001810 Genomic DNA. Translation: ADL33842.1 .
RefSeqi WP_013280498.1. NC_014387.1.
YP_003830424.1. NC_014387.1.

3D structure databases

ProteinModelPortali E0S217.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E0S217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL33842 ; ADL33842 ; bpr_I1102 .
GeneIDi 9574755.
KEGGi bpb:bpr_I1102.
PATRICi 42221475. VBIButPro41874_1110.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi CVNTVET.

Enzyme and pathway databases

BioCyci BPRO515622:GHKV-1125-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Glycobiome of the Rumen Bacterium Butyrivibrio proteoclasticus B316 Highlights Adaptation to a Polysaccharide-Rich Environment."
    Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z., Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.
    PLoS ONE 5:E11942-E11942(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51982 / DSM 14932 / B316.

Entry informationi

Entry nameiE0S217_BUTPB
AccessioniPrimary (citable) accession number: E0S217
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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