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E0S217

- E0S217_BUTPB

UniProt

E0S217 - E0S217_BUTPB

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei325 – 3251NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi307 – 3126NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPRO515622:GHKV-1125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:bpr_I1102Imported
OrganismiButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)Imported
Taxonomic identifieri515622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
ProteomesiUP000001299: Chromosome 1

PTM / Processingi

Proteomic databases

PRIDEiE0S217.

Structurei

3D structure databases

ProteinModelPortaliE0S217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiCVNTVET.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0S217-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKIQMTTPI VEMDGDEMTR VLWQLIKDKL ILPYVDLKSE YYDLGLKHRD
60 70 80 90 100
ETDDQVTVDS ANATLKYGVA VKCATITPND ERVKEYSLKK MYKSPNGTIR
110 120 130 140 150
AILDGTVFRT PIMVKGIEPN VRTWESPITL ARHAYGDVYK NVEIRVPGPG
160 170 180 190 200
KAELVFTGAD GTEIRETIHE FTEPGIIQGM HNKDASIESF ARACFKYALS
210 220 230 240 250
EKKELWLGTK DTISKTYDRR FRDIFDEIYE KEFKEDFEKA GITYFYTLID
260 270 280 290 300
DAVARVMKSK GGFIWACKNY DGDVMSDMVS SAFGSLAMMT SVLVSPSGVY
310 320 330 340 350
EYEAAHGTVQ RHYYKYLKGE PTSTNPVATI FAWTGALRKR GELDNIKELM
360 370 380 390 400
EFADKLEKAT LSVIESGRMT GDLALITSLP NPVKLGSEEF LDAIAAELET

I
Length:401
Mass (Da):45,140
Last modified:November 2, 2010 - v1
Checksum:iC3CC04E8089EC291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001810 Genomic DNA. Translation: ADL33842.1.
RefSeqiWP_013280498.1. NC_014387.1.
YP_003830424.1. NC_014387.1.

Genome annotation databases

EnsemblBacteriaiADL33842; ADL33842; bpr_I1102.
GeneIDi9574755.
KEGGibpb:bpr_I1102.
PATRICi42221475. VBIButPro41874_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001810 Genomic DNA. Translation: ADL33842.1 .
RefSeqi WP_013280498.1. NC_014387.1.
YP_003830424.1. NC_014387.1.

3D structure databases

ProteinModelPortali E0S217.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E0S217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL33842 ; ADL33842 ; bpr_I1102 .
GeneIDi 9574755.
KEGGi bpb:bpr_I1102.
PATRICi 42221475. VBIButPro41874_1110.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi CVNTVET.

Enzyme and pathway databases

BioCyci BPRO515622:GHKV-1125-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The glycobiome of the rumen bacterium Butyrivibrio proteoclasticus B316(T) highlights adaptation to a polysaccharide-rich environment."
    Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z., Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.
    PLoS ONE 5:E11942-E11942(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51982 / DSM 14932 / B316Imported.

Entry informationi

Entry nameiE0S217_BUTPB
AccessioniPrimary (citable) accession number: E0S217
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3