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E0S217 (E0S217_BUTPB) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding307 – 3126NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3251NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
E0S217 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: C3CC04E8089EC291

FASTA40145,140
        10         20         30         40         50         60 
MGKIQMTTPI VEMDGDEMTR VLWQLIKDKL ILPYVDLKSE YYDLGLKHRD ETDDQVTVDS 

        70         80         90        100        110        120 
ANATLKYGVA VKCATITPND ERVKEYSLKK MYKSPNGTIR AILDGTVFRT PIMVKGIEPN 

       130        140        150        160        170        180 
VRTWESPITL ARHAYGDVYK NVEIRVPGPG KAELVFTGAD GTEIRETIHE FTEPGIIQGM 

       190        200        210        220        230        240 
HNKDASIESF ARACFKYALS EKKELWLGTK DTISKTYDRR FRDIFDEIYE KEFKEDFEKA 

       250        260        270        280        290        300 
GITYFYTLID DAVARVMKSK GGFIWACKNY DGDVMSDMVS SAFGSLAMMT SVLVSPSGVY 

       310        320        330        340        350        360 
EYEAAHGTVQ RHYYKYLKGE PTSTNPVATI FAWTGALRKR GELDNIKELM EFADKLEKAT 

       370        380        390        400 
LSVIESGRMT GDLALITSLP NPVKLGSEEF LDAIAAELET I 

« Hide

References

[1]"The glycobiome of the rumen bacterium Butyrivibrio proteoclasticus B316(T) highlights adaptation to a polysaccharide-rich environment."
Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z., Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.
PLoS ONE 5:E11942-E11942(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51982 / DSM 14932 / B316.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001810 Genomic DNA. Translation: ADL33842.1.
RefSeqYP_003830424.1. NC_014387.1.

3D structure databases

ProteinModelPortalE0S217.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEE0S217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADL33842; ADL33842; bpr_I1102.
GeneID9574755.
KEGGbpb:bpr_I1102.
PATRIC42221475. VBIButPro41874_1110.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycBPRO515622:GHKV-1125-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE0S217_BUTPB
AccessionPrimary (citable) accession number: E0S217
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: December 11, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)