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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Sitei139Critical for catalysisUniRule annotation1
Sitei210Critical for catalysisUniRule annotation1
Metal bindingi250Magnesium or manganeseUniRule annotation1
Binding sitei258NADPUniRule annotation1
Metal bindingi273Magnesium or manganeseUniRule annotation1
Binding sitei325NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 77NADPUniRule annotation3
Nucleotide bindingi307 – 312NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPRO515622:G1GMG-1125-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:bpr_I1102Imported
OrganismiButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)Imported
Taxonomic identifieri515622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
Proteomesi
  • UP000001299 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi515622.bpr_I1102

Structurei

3D structure databases

ProteinModelPortaliE0S217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 394Iso_dhInterPro annotationAdd BLAST386

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 100Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5N Bacteria
COG0538 LUCA
HOGENOMiHOG000019858
KOiK00031
OMAiAMGMYNQ
OrthoDBiPOG091H0JP0

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

E0S217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIQMTTPI VEMDGDEMTR VLWQLIKDKL ILPYVDLKSE YYDLGLKHRD
60 70 80 90 100
ETDDQVTVDS ANATLKYGVA VKCATITPND ERVKEYSLKK MYKSPNGTIR
110 120 130 140 150
AILDGTVFRT PIMVKGIEPN VRTWESPITL ARHAYGDVYK NVEIRVPGPG
160 170 180 190 200
KAELVFTGAD GTEIRETIHE FTEPGIIQGM HNKDASIESF ARACFKYALS
210 220 230 240 250
EKKELWLGTK DTISKTYDRR FRDIFDEIYE KEFKEDFEKA GITYFYTLID
260 270 280 290 300
DAVARVMKSK GGFIWACKNY DGDVMSDMVS SAFGSLAMMT SVLVSPSGVY
310 320 330 340 350
EYEAAHGTVQ RHYYKYLKGE PTSTNPVATI FAWTGALRKR GELDNIKELM
360 370 380 390 400
EFADKLEKAT LSVIESGRMT GDLALITSLP NPVKLGSEEF LDAIAAELET

I
Length:401
Mass (Da):45,140
Last modified:November 2, 2010 - v1
Checksum:iC3CC04E8089EC291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001810 Genomic DNA Translation: ADL33842.1
RefSeqiWP_013280498.1, NC_014387.1

Genome annotation databases

EnsemblBacteriaiADL33842; ADL33842; bpr_I1102
GeneIDi31782281
KEGGibpb:bpr_I1102

Similar proteinsi

Entry informationi

Entry nameiE0S217_BUTPB
AccessioniPrimary (citable) accession number: E0S217
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health