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E0S217

- E0S217_BUTPB

UniProt

E0S217 - E0S217_BUTPB

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei325 – 3251NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi307 – 3126NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBPRO515622:GHKV-1125-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:bpr_I1102Imported
    OrganismiButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)Imported
    Taxonomic identifieri515622 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
    ProteomesiUP000001299: Chromosome 1

    PTM / Processingi

    Proteomic databases

    PRIDEiE0S217.

    Structurei

    3D structure databases

    ProteinModelPortaliE0S217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiCVNTVET.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0S217-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKIQMTTPI VEMDGDEMTR VLWQLIKDKL ILPYVDLKSE YYDLGLKHRD    50
    ETDDQVTVDS ANATLKYGVA VKCATITPND ERVKEYSLKK MYKSPNGTIR 100
    AILDGTVFRT PIMVKGIEPN VRTWESPITL ARHAYGDVYK NVEIRVPGPG 150
    KAELVFTGAD GTEIRETIHE FTEPGIIQGM HNKDASIESF ARACFKYALS 200
    EKKELWLGTK DTISKTYDRR FRDIFDEIYE KEFKEDFEKA GITYFYTLID 250
    DAVARVMKSK GGFIWACKNY DGDVMSDMVS SAFGSLAMMT SVLVSPSGVY 300
    EYEAAHGTVQ RHYYKYLKGE PTSTNPVATI FAWTGALRKR GELDNIKELM 350
    EFADKLEKAT LSVIESGRMT GDLALITSLP NPVKLGSEEF LDAIAAELET 400
    I 401
    Length:401
    Mass (Da):45,140
    Last modified:November 2, 2010 - v1
    Checksum:iC3CC04E8089EC291
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001810 Genomic DNA. Translation: ADL33842.1.
    RefSeqiWP_013280498.1. NC_014387.1.
    YP_003830424.1. NC_014387.1.

    Genome annotation databases

    EnsemblBacteriaiADL33842; ADL33842; bpr_I1102.
    GeneIDi9574755.
    KEGGibpb:bpr_I1102.
    PATRICi42221475. VBIButPro41874_1110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001810 Genomic DNA. Translation: ADL33842.1 .
    RefSeqi WP_013280498.1. NC_014387.1.
    YP_003830424.1. NC_014387.1.

    3D structure databases

    ProteinModelPortali E0S217.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E0S217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL33842 ; ADL33842 ; bpr_I1102 .
    GeneIDi 9574755.
    KEGGi bpb:bpr_I1102.
    PATRICi 42221475. VBIButPro41874_1110.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi CVNTVET.

    Enzyme and pathway databases

    BioCyci BPRO515622:GHKV-1125-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glycobiome of the rumen bacterium Butyrivibrio proteoclasticus B316(T) highlights adaptation to a polysaccharide-rich environment."
      Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z., Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.
      PLoS ONE 5:E11942-E11942(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51982 / DSM 14932 / B316Imported.

    Entry informationi

    Entry nameiE0S217_BUTPB
    AccessioniPrimary (citable) accession number: E0S217
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3