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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotationSAAS annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation
LigandNADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBPRO515622:G1GMG-1349-MONOMER
UniPathwayiUPA00098; UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotationImported
Ordered Locus Names:bpr_I1324Imported
OrganismiButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)Imported
Taxonomic identifieri515622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
Proteomesi
  • UP000001299 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi515622.bpr_I1324

Structurei

3D structure databases

ProteinModelPortaliE0RUM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 284AldedhInterPro annotationAdd BLAST280
Domaini314 – 376AldedhInterPro annotationAdd BLAST63

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C2S Bacteria
COG0014 LUCA
HOGENOMiHOG000246356
KOiK00147
OMAiHGSHHTD
OrthoDBiPOG091H00OT

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 2 hits
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

E0RUM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVEICRRA KDVKYEVQKL STQAKNKALI SVADALVKRT DFIIEANRKD
60 70 80 90 100
YDNGLSNGMH QGMLDRLKLD GKRIEAMAEG LRQVAELEDP IGTEIEHFVR
110 120 130 140 150
PNGLEISKVR VPFGVIGIIY ESRPNVTADA FGLTFKSGNA VILKGGSDAI
160 170 180 190 200
NSNIAITTVI RDALKEENIN PDAVQLIEAT DRAVTTQFMQ MKEYVDVLIP
210 220 230 240 250
RGSARLISAV VENSTIPVIE TGTGNCHIYV DKDADLDKAI PIIINAKTQR
260 270 280 290 300
IGVCNAAESL VVHKDIKDKF LPLFGAAMKE KNVEVRADAA AREILTGAVP
310 320 330 340 350
ANEEDFGKEY LDYIISVKTV SDVSEAISHI NKYNTGHSEA IITENEETAK
360 370 380 390 400
KFLNEVDAAC VYVNASTRFT DGFEFGFGAE IGISTQKLHA RGPMGLKELT
410
SYKYRIVGNG QIRG
Length:414
Mass (Da):45,422
Last modified:November 2, 2010 - v1
Checksum:iA85AF90A6AB1A312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001810 Genomic DNA Translation: ADL34062.1
RefSeqiWP_013280716.1, NC_014387.1

Genome annotation databases

EnsemblBacteriaiADL34062; ADL34062; bpr_I1324
GeneIDi31782492
KEGGibpb:bpr_I1324

Similar proteinsi

Entry informationi

Entry nameiE0RUM1_BUTPB
AccessioniPrimary (citable) accession number: E0RUM1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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