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E0RUM1

- E0RUM1_BUTPB

UniProt

E0RUM1 - E0RUM1_BUTPB

Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation
    Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.SAAS annotation

    Catalytic activityi

    L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBPRO515622:GHKV-1349-MONOMER.
    UniPathwayiUPA00098; UER00360.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
    Short name:
    GPRUniRule annotation
    Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
    Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:proAUniRule annotationImported
    Ordered Locus Names:bpr_I1324Imported
    OrganismiButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)Imported
    Taxonomic identifieri515622 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
    ProteomesiUP000001299: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiE0RUM1.

    Structurei

    3D structure databases

    ProteinModelPortaliE0RUM1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000246356.
    KOiK00147.
    OMAiEERIHEF.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPiMF_00412. ProA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000151. GPR. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00407. proA. 1 hit.
    PROSITEiPS01223. PROA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0RUM1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELVEICRRA KDVKYEVQKL STQAKNKALI SVADALVKRT DFIIEANRKD    50
    YDNGLSNGMH QGMLDRLKLD GKRIEAMAEG LRQVAELEDP IGTEIEHFVR 100
    PNGLEISKVR VPFGVIGIIY ESRPNVTADA FGLTFKSGNA VILKGGSDAI 150
    NSNIAITTVI RDALKEENIN PDAVQLIEAT DRAVTTQFMQ MKEYVDVLIP 200
    RGSARLISAV VENSTIPVIE TGTGNCHIYV DKDADLDKAI PIIINAKTQR 250
    IGVCNAAESL VVHKDIKDKF LPLFGAAMKE KNVEVRADAA AREILTGAVP 300
    ANEEDFGKEY LDYIISVKTV SDVSEAISHI NKYNTGHSEA IITENEETAK 350
    KFLNEVDAAC VYVNASTRFT DGFEFGFGAE IGISTQKLHA RGPMGLKELT 400
    SYKYRIVGNG QIRG 414
    Length:414
    Mass (Da):45,422
    Last modified:November 2, 2010 - v1
    Checksum:iA85AF90A6AB1A312
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001810 Genomic DNA. Translation: ADL34062.1.
    RefSeqiYP_003830644.1. NC_014387.1.

    Genome annotation databases

    EnsemblBacteriaiADL34062; ADL34062; bpr_I1324.
    GeneIDi9574975.
    KEGGibpb:bpr_I1324.
    PATRICi42221931. VBIButPro41874_1335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001810 Genomic DNA. Translation: ADL34062.1 .
    RefSeqi YP_003830644.1. NC_014387.1.

    3D structure databases

    ProteinModelPortali E0RUM1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E0RUM1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL34062 ; ADL34062 ; bpr_I1324 .
    GeneIDi 9574975.
    KEGGi bpb:bpr_I1324.
    PATRICi 42221931. VBIButPro41874_1335.

    Phylogenomic databases

    HOGENOMi HOG000246356.
    KOi K00147.
    OMAi EERIHEF.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00360 .
    BioCyci BPRO515622:GHKV-1349-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPi MF_00412. ProA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000151. GPR. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00407. proA. 1 hit.
    PROSITEi PS01223. PROA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glycobiome of the rumen bacterium Butyrivibrio proteoclasticus B316(T) highlights adaptation to a polysaccharide-rich environment."
      Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z., Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.
      PLoS ONE 5:E11942-E11942(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51982 / DSM 14932 / B316Imported.

    Entry informationi

    Entry nameiE0RUM1_BUTPB
    AccessioniPrimary (citable) accession number: E0RUM1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3