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E0RUM1 (E0RUM1_BUTPB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP-Rule MF_00412
Short name=GPR HAMAP-Rule MF_00412
EC=1.2.1.41 HAMAP-Rule MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Gene names
Name:proA HAMAP-Rule MF_00412 EMBL ADL34062.1
Ordered Locus Names:bpr_I1324 EMBL ADL34062.1
OrganismButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum) [Complete proteome] [HAMAP]
Taxonomic identifier515622 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Lachnospiraceae › Butyrivibrio ›

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP-Rule MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP-Rule MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP-Rule MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP-Rule MF_00412

Sequences

Sequence LengthMass (Da)Tools
E0RUM1 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: A85AF90A6AB1A312

FASTA41445,422
        10         20         30         40         50         60 
MELVEICRRA KDVKYEVQKL STQAKNKALI SVADALVKRT DFIIEANRKD YDNGLSNGMH 

        70         80         90        100        110        120 
QGMLDRLKLD GKRIEAMAEG LRQVAELEDP IGTEIEHFVR PNGLEISKVR VPFGVIGIIY 

       130        140        150        160        170        180 
ESRPNVTADA FGLTFKSGNA VILKGGSDAI NSNIAITTVI RDALKEENIN PDAVQLIEAT 

       190        200        210        220        230        240 
DRAVTTQFMQ MKEYVDVLIP RGSARLISAV VENSTIPVIE TGTGNCHIYV DKDADLDKAI 

       250        260        270        280        290        300 
PIIINAKTQR IGVCNAAESL VVHKDIKDKF LPLFGAAMKE KNVEVRADAA AREILTGAVP 

       310        320        330        340        350        360 
ANEEDFGKEY LDYIISVKTV SDVSEAISHI NKYNTGHSEA IITENEETAK KFLNEVDAAC 

       370        380        390        400        410 
VYVNASTRFT DGFEFGFGAE IGISTQKLHA RGPMGLKELT SYKYRIVGNG QIRG

« Hide

References

[1]"The glycobiome of the rumen bacterium Butyrivibrio proteoclasticus B316(T) highlights adaptation to a polysaccharide-rich environment."
Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z., Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.
PLoS ONE 5:E11942-E11942(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51982 / DSM 14932 / B316.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001810 Genomic DNA. Translation: ADL34062.1.
RefSeqYP_003830644.1. NC_014387.1.

3D structure databases

ProteinModelPortalE0RUM1.
ModBaseSearch...

Proteomic databases

PRIDEE0RUM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADL34062; ADL34062; bpr_I1324.
GeneID9574975.
KEGGbpb:bpr_I1324.
PATRIC42221931. VBIButPro41874_1335.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000246356.
KOK00147.
OMASIISEHQ.

Enzyme and pathway databases

BioCycBPRO515622:GHKV-2193-MONOMER.
UniPathwayUPA00098; UER00360.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPMF_00412. ProA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PANTHERPTHR11063:SF1. PTHR11063:SF1. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. proA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE0RUM1_BUTPB
AccessionPrimary (citable) accession number: E0RUM1
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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