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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Butyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotationSAAS annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBPRO515622:GHKV-1349-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotationSAAS annotation (EC:1.2.1.41UniRule annotationSAAS annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotationImported
Ordered Locus Names:bpr_I1324Imported
OrganismiButyrivibrio proteoclasticus (strain ATCC 51982 / DSM 14932 / B316) (Clostridium proteoclasticum)Imported
Taxonomic identifieri515622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
ProteomesiUP000001299 Componenti: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiE0RUM1.

Structurei

3D structure databases

ProteinModelPortaliE0RUM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246356.
KOiK00147.
OMAiAHFMNEV.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0RUM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVEICRRA KDVKYEVQKL STQAKNKALI SVADALVKRT DFIIEANRKD
60 70 80 90 100
YDNGLSNGMH QGMLDRLKLD GKRIEAMAEG LRQVAELEDP IGTEIEHFVR
110 120 130 140 150
PNGLEISKVR VPFGVIGIIY ESRPNVTADA FGLTFKSGNA VILKGGSDAI
160 170 180 190 200
NSNIAITTVI RDALKEENIN PDAVQLIEAT DRAVTTQFMQ MKEYVDVLIP
210 220 230 240 250
RGSARLISAV VENSTIPVIE TGTGNCHIYV DKDADLDKAI PIIINAKTQR
260 270 280 290 300
IGVCNAAESL VVHKDIKDKF LPLFGAAMKE KNVEVRADAA AREILTGAVP
310 320 330 340 350
ANEEDFGKEY LDYIISVKTV SDVSEAISHI NKYNTGHSEA IITENEETAK
360 370 380 390 400
KFLNEVDAAC VYVNASTRFT DGFEFGFGAE IGISTQKLHA RGPMGLKELT
410
SYKYRIVGNG QIRG
Length:414
Mass (Da):45,422
Last modified:November 1, 2010 - v1
Checksum:iA85AF90A6AB1A312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001810 Genomic DNA. Translation: ADL34062.1.
RefSeqiWP_013280716.1. NC_014387.1.
YP_003830644.1. NC_014387.1.

Genome annotation databases

EnsemblBacteriaiADL34062; ADL34062; bpr_I1324.
KEGGibpb:bpr_I1324.
PATRICi42221931. VBIButPro41874_1335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001810 Genomic DNA. Translation: ADL34062.1.
RefSeqiWP_013280716.1. NC_014387.1.
YP_003830644.1. NC_014387.1.

3D structure databases

ProteinModelPortaliE0RUM1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE0RUM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL34062; ADL34062; bpr_I1324.
KEGGibpb:bpr_I1324.
PATRICi42221931. VBIButPro41874_1335.

Phylogenomic databases

HOGENOMiHOG000246356.
KOiK00147.
OMAiAHFMNEV.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.
BioCyciBPRO515622:GHKV-1349-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Glycobiome of the Rumen Bacterium Butyrivibrio proteoclasticus B316 Highlights Adaptation to a Polysaccharide-Rich Environment."
    Kelly W.J., Leahy S.C., Altermann E., Yeoman C.J., Dunne J.C., Kong Z., Pacheco D.M., Li D., Noel S.J., Moon C.D., Cookson A.L., Attwood G.T.
    PLoS ONE 5:E11942-E11942(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51982 / DSM 14932 / B316Imported.

Entry informationi

Entry nameiE0RUM1_BUTPB
AccessioniPrimary (citable) accession number: E0RUM1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 2010
Last sequence update: November 1, 2010
Last modified: March 31, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.