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E0RQQ5

- E0RQQ5_SPITD

UniProt

E0RQQ5 - E0RQQ5_SPITD

Protein
Submitted name:

D-alanine-D-alanine ligase related protein

Gene

STHERM_c06000

Organism
Spirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Cell wall formation.SAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTHE665571:GI3Y-600-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    D-alanine-D-alanine ligase related proteinImported
    Gene namesi
    Ordered Locus Names:STHERM_c06000Imported
    OrganismiSpirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)Imported
    Taxonomic identifieri665571 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
    ProteomesiUP000001296: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE0RQQ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 ATP-grasp domain.
    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000244781.
    KOiK01921.
    OMAiNDPRKEL.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.150. 2 hits.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR025714. Methyltranfer_dom.
    IPR016185. PreATP-grasp_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF13847. Methyltransf_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    SSF53335. SSF53335. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0RQQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKVRDTDK PPERRRRRIP AARARCLGPL SDLESHVAPD WWSRIFNSYY    50
    MKTDGDVVDD LAITRREVDL FTSVLDLRED EAVLDLCCGQ GRHSLELARR 100
    GFTKVEGLDR SHYLIQRAKA QAAKEGIPVR FREGDARKLP HPPDQFDVVM 150
    ILGNSFGYFE TSKDDLLVLK EVARVLKPWG RVLLDLADGD FLRAHYVPRS 200
    WEWIDPKHFV CRERALSADR QRLISREVIV HTEKGVEVDQ FYAERLYTPE 250
    LIRSLLEEAG FQEVSFHGTL TPDSARGQDL GMMERRILVS ARIRKEWTPV 300
    KPKKKNVSTQ VAVVMGDPSK PDPLKPFMVF DDDDFYTIDR LKAALKECTG 350
    YSFTYLSRHE TLIQDLMRLK GKIDYVFNLC DEGFFNDPRK ELHVPALLEM 400
    LGIPYTGATP QGLAFCYDKS LVRGVAKEMG VPVPRAFFID PTSIVFEVPF 450
    GFPMIVKPNL GDSSFGITQK SVVWSLDELS ACISEIRDTF GYEKPVLVEE 500
    FLTGKDLTVG IIGNPPDDYM VLPIVEEDYS ALPPELPRIC GYEAKWLPDS 550
    PYWKALQSIP AGLPEATEKS IVEWCVRLFE RLECRDYARF DWRCDADGNP 600
    YLLEVNPNPG WCWDGHLAKM ARLAGMEYPQ MLQAILKAAE RRLGIR 646
    Length:646
    Mass (Da):73,893
    Last modified:November 2, 2010 - v1
    Checksum:iAD1D2FC207D98DDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001698 Genomic DNA. Translation: ADN01559.1.
    RefSeqiYP_003873832.1. NC_014484.1.

    Genome annotation databases

    EnsemblBacteriaiADN01559; ADN01559; STHERM_c06000.
    GeneIDi9755854.
    KEGGista:STHERM_c06000.
    PATRICi42520415. VBISpiThe146732_0594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001698 Genomic DNA. Translation: ADN01559.1 .
    RefSeqi YP_003873832.1. NC_014484.1.

    3D structure databases

    ProteinModelPortali E0RQQ5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADN01559 ; ADN01559 ; STHERM_c06000 .
    GeneIDi 9755854.
    KEGGi sta:STHERM_c06000.
    PATRICi 42520415. VBISpiThe146732_0594.

    Phylogenomic databases

    HOGENOMi HOG000244781.
    KOi K01921.
    OMAi NDPRKEL.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci STHE665571:GI3Y-600-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.150. 2 hits.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR025714. Methyltranfer_dom.
    IPR016185. PreATP-grasp_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF13847. Methyltransf_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    SSF53335. SSF53335. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Spirochaeta thermophila DSM6192."
      Angelov A., Mientus M., Wittenberg S., Lehmann R., Liesegang H., Daniel R., Liebl W.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 6192.
    2. "Genome sequence of the polysaccharide-degrading, thermophilic anaerobe Spirochaeta thermophila DSM 6192."
      Angelov A., Liebl S., Ballschmiter M., Bomeke M., Lehmann R., Liesegang H., Daniel R., Liebl W.
      J. Bacteriol. 192:6492-6493(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49972 / DSM 6192 / RI 19.B1Imported.

    Entry informationi

    Entry nameiE0RQQ5_SPITD
    AccessioniPrimary (citable) accession number: E0RQQ5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3