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E0RQQ5

- E0RQQ5_SPITD

UniProt

E0RQQ5 - E0RQQ5_SPITD

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Protein
Submitted name:

D-alanine-D-alanine ligase related protein

Gene

STHERM_c06000

Organism
Spirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE665571:GI3Y-600-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine-D-alanine ligase related proteinImported
Gene namesi
Ordered Locus Names:STHERM_c06000Imported
OrganismiSpirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)Imported
Taxonomic identifieri665571 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000001296: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliE0RQQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000244781.
KOiK01921.
OMAiNDPRKEL.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.150. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR025714. Methyltranfer_dom.
IPR016185. PreATP-grasp_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0RQQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEKVRDTDK PPERRRRRIP AARARCLGPL SDLESHVAPD WWSRIFNSYY
60 70 80 90 100
MKTDGDVVDD LAITRREVDL FTSVLDLRED EAVLDLCCGQ GRHSLELARR
110 120 130 140 150
GFTKVEGLDR SHYLIQRAKA QAAKEGIPVR FREGDARKLP HPPDQFDVVM
160 170 180 190 200
ILGNSFGYFE TSKDDLLVLK EVARVLKPWG RVLLDLADGD FLRAHYVPRS
210 220 230 240 250
WEWIDPKHFV CRERALSADR QRLISREVIV HTEKGVEVDQ FYAERLYTPE
260 270 280 290 300
LIRSLLEEAG FQEVSFHGTL TPDSARGQDL GMMERRILVS ARIRKEWTPV
310 320 330 340 350
KPKKKNVSTQ VAVVMGDPSK PDPLKPFMVF DDDDFYTIDR LKAALKECTG
360 370 380 390 400
YSFTYLSRHE TLIQDLMRLK GKIDYVFNLC DEGFFNDPRK ELHVPALLEM
410 420 430 440 450
LGIPYTGATP QGLAFCYDKS LVRGVAKEMG VPVPRAFFID PTSIVFEVPF
460 470 480 490 500
GFPMIVKPNL GDSSFGITQK SVVWSLDELS ACISEIRDTF GYEKPVLVEE
510 520 530 540 550
FLTGKDLTVG IIGNPPDDYM VLPIVEEDYS ALPPELPRIC GYEAKWLPDS
560 570 580 590 600
PYWKALQSIP AGLPEATEKS IVEWCVRLFE RLECRDYARF DWRCDADGNP
610 620 630 640
YLLEVNPNPG WCWDGHLAKM ARLAGMEYPQ MLQAILKAAE RRLGIR
Length:646
Mass (Da):73,893
Last modified:November 2, 2010 - v1
Checksum:iAD1D2FC207D98DDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001698 Genomic DNA. Translation: ADN01559.1.
RefSeqiYP_003873832.1. NC_014484.1.

Genome annotation databases

EnsemblBacteriaiADN01559; ADN01559; STHERM_c06000.
GeneIDi9755854.
KEGGista:STHERM_c06000.
PATRICi42520415. VBISpiThe146732_0594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001698 Genomic DNA. Translation: ADN01559.1 .
RefSeqi YP_003873832.1. NC_014484.1.

3D structure databases

ProteinModelPortali E0RQQ5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADN01559 ; ADN01559 ; STHERM_c06000 .
GeneIDi 9755854.
KEGGi sta:STHERM_c06000.
PATRICi 42520415. VBISpiThe146732_0594.

Phylogenomic databases

HOGENOMi HOG000244781.
KOi K01921.
OMAi NDPRKEL.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci STHE665571:GI3Y-600-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.150. 2 hits.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR025714. Methyltranfer_dom.
IPR016185. PreATP-grasp_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF13847. Methyltransf_31. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Spirochaeta thermophila DSM6192."
    Angelov A., Mientus M., Wittenberg S., Lehmann R., Liesegang H., Daniel R., Liebl W.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 6192.
  2. "Genome sequence of the polysaccharide-degrading, thermophilic anaerobe Spirochaeta thermophila DSM 6192."
    Angelov A., Liebl S., Ballschmiter M., Bomeke M., Lehmann R., Liesegang H., Daniel R., Liebl W.
    J. Bacteriol. 192:6492-6493(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49972 / DSM 6192 / RI 19.B1Imported.

Entry informationi

Entry nameiE0RQQ5_SPITD
AccessioniPrimary (citable) accession number: E0RQQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3