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E0RQQ0

- E0RQQ0_SPITD

UniProt

E0RQQ0 - E0RQQ0_SPITD

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Protein

Alanine racemase

Gene
STHERM_c05940
Organism
Spirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei133 – 1331Substrate By similarityUniRule annotation
Active sitei262 – 2621Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSTHE665571:GI3Y-594-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:STHERM_c05940Imported
OrganismiSpirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)Imported
Taxonomic identifieri665571 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000001296: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE0RQQ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiAEININN.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0RQQ0-1 [UniParc]FASTAAdd to Basket

« Hide

MGVRGTHAVI YLSHLRHNLR EIRRRVGEGR MVCAAVKADA YGHGAVEVGK    50
VLVEEGVEML GVATPEEGAE LAGVGARVLL LGLTDGAGLE LAVEAGLELA 100
VGDREYVREV ARVARAKGRR VRVHVEVDTG MGRTGCAPEE AVGVVEEVEG 150
AGVLELAGMW THFPSSDEAD DGFTEAQVER FLQVVGRVRA RGISPGLLHA 200
ANSGGIIGHP PSWLDMVRPG ISLYGYYPSE EQERTLSLLP VMEFVSQVVF 250
LKKVRKGTPV SYGRTWRAPR DTWIATVAAG YADGYSRLLS SRAEVLIRGR 300
RYPVVGRVCM DQFMVDVGPH PRVRRYDRVV LFGPDPSGPS AEELARLVGT 350
IPYEITCAVS RRVPRLYVEE SPYLSGGSSS AHRGGLTRYE R 391
Length:391
Mass (Da):42,496
Last modified:November 2, 2010 - v1
Checksum:i6804E6A558002A4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001698 Genomic DNA. Translation: ADN01554.1.
RefSeqiWP_013313395.1. NC_014484.1.
YP_003873827.1. NC_014484.1.

Genome annotation databases

EnsemblBacteriaiADN01554; ADN01554; STHERM_c05940.
GeneIDi9755848.
KEGGista:STHERM_c05940.
PATRICi42520403. VBISpiThe146732_0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001698 Genomic DNA. Translation: ADN01554.1 .
RefSeqi WP_013313395.1. NC_014484.1.
YP_003873827.1. NC_014484.1.

3D structure databases

ProteinModelPortali E0RQQ0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADN01554 ; ADN01554 ; STHERM_c05940 .
GeneIDi 9755848.
KEGGi sta:STHERM_c05940.
PATRICi 42520403. VBISpiThe146732_0589.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi AEININN.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci STHE665571:GI3Y-594-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Spirochaeta thermophila DSM6192."
    Angelov A., Mientus M., Wittenberg S., Lehmann R., Liesegang H., Daniel R., Liebl W.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 6192.
  2. "Genome sequence of the polysaccharide-degrading, thermophilic anaerobe Spirochaeta thermophila DSM 6192."
    Angelov A., Liebl S., Ballschmiter M., Bomeke M., Lehmann R., Liesegang H., Daniel R., Liebl W.
    J. Bacteriol. 192:6492-6493(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49972 / DSM 6192 / RI 19.B1.

Entry informationi

Entry nameiE0RQQ0_SPITD
AccessioniPrimary (citable) accession number: E0RQQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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