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E0RQQ0

- E0RQQ0_SPITD

UniProt

E0RQQ0 - E0RQQ0_SPITD

Protein

Alanine racemase

Gene

STHERM_c05940

Organism
Spirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Active sitei262 – 2621Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSTHE665571:GI3Y-594-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:STHERM_c05940Imported
    OrganismiSpirochaeta thermophila (strain ATCC 49972 / DSM 6192 / RI 19.B1)Imported
    Taxonomic identifieri665571 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
    ProteomesiUP000001296: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE0RQQ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiAEININN.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0RQQ0-1 [UniParc]FASTAAdd to Basket

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    MGVRGTHAVI YLSHLRHNLR EIRRRVGEGR MVCAAVKADA YGHGAVEVGK    50
    VLVEEGVEML GVATPEEGAE LAGVGARVLL LGLTDGAGLE LAVEAGLELA 100
    VGDREYVREV ARVARAKGRR VRVHVEVDTG MGRTGCAPEE AVGVVEEVEG 150
    AGVLELAGMW THFPSSDEAD DGFTEAQVER FLQVVGRVRA RGISPGLLHA 200
    ANSGGIIGHP PSWLDMVRPG ISLYGYYPSE EQERTLSLLP VMEFVSQVVF 250
    LKKVRKGTPV SYGRTWRAPR DTWIATVAAG YADGYSRLLS SRAEVLIRGR 300
    RYPVVGRVCM DQFMVDVGPH PRVRRYDRVV LFGPDPSGPS AEELARLVGT 350
    IPYEITCAVS RRVPRLYVEE SPYLSGGSSS AHRGGLTRYE R 391
    Length:391
    Mass (Da):42,496
    Last modified:November 2, 2010 - v1
    Checksum:i6804E6A558002A4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001698 Genomic DNA. Translation: ADN01554.1.
    RefSeqiWP_013313395.1. NC_014484.1.
    YP_003873827.1. NC_014484.1.

    Genome annotation databases

    EnsemblBacteriaiADN01554; ADN01554; STHERM_c05940.
    GeneIDi9755848.
    KEGGista:STHERM_c05940.
    PATRICi42520403. VBISpiThe146732_0589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001698 Genomic DNA. Translation: ADN01554.1 .
    RefSeqi WP_013313395.1. NC_014484.1.
    YP_003873827.1. NC_014484.1.

    3D structure databases

    ProteinModelPortali E0RQQ0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADN01554 ; ADN01554 ; STHERM_c05940 .
    GeneIDi 9755848.
    KEGGi sta:STHERM_c05940.
    PATRICi 42520403. VBISpiThe146732_0589.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi AEININN.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci STHE665571:GI3Y-594-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Spirochaeta thermophila DSM6192."
      Angelov A., Mientus M., Wittenberg S., Lehmann R., Liesegang H., Daniel R., Liebl W.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 6192.
    2. "Genome sequence of the polysaccharide-degrading, thermophilic anaerobe Spirochaeta thermophila DSM 6192."
      Angelov A., Liebl S., Ballschmiter M., Bomeke M., Lehmann R., Liesegang H., Daniel R., Liebl W.
      J. Bacteriol. 192:6492-6493(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49972 / DSM 6192 / RI 19.B1Imported.

    Entry informationi

    Entry nameiE0RQQ0_SPITD
    AccessioniPrimary (citable) accession number: E0RQQ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3