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Protein

Thymidine kinase

Gene

PPE_02825

Organism
Paenibacillus polymyxa (strain E681)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPOL349520:GH6J-2816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Ordered Locus Names:PPE_02825Imported
OrganismiPaenibacillus polymyxa (strain E681)Imported
Taxonomic identifieri349520 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002227 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349520.PPE_02825.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiCAGLDQD.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

E0RDB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTGRITIIT GPMFSEKSGE LIRRCQKLIQ YGHRKVVAYK PAEDNRYAED
60 70 80 90 100
EIVSRIGYRL PAISIPRKLT DELVQRILQE TKDADVVAFD EVQFFSRHIM
110 120 130 140 150
SLVQELAYYG KHVIADGLNL DYRGKEFGYV GGLLAMADDI EKLTSFCAVC
160 170 180 190
GSSEAVFTQR MVNGKPSTVG PIVMIGDSEA YEPRCRNCFI PPHKVNCD
Length:198
Mass (Da):22,257
Last modified:November 2, 2010 - v1
Checksum:i617FF16DC8E8FE6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000154 Genomic DNA. Translation: ADM70652.1.
RefSeqiWP_013310800.1. NC_014483.2.

Genome annotation databases

EnsemblBacteriaiADM70652; ADM70652; PPE_02825.
KEGGippy:PPE_02825.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE0RDB7_PAEP6
AccessioniPrimary (citable) accession number: E0RDB7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: July 5, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported